PharmacoDB

Sources

Names Used

Afatinib

BIBW2992

afatinib

PharmacoGx

BIBW2992

Database	Identifier
Smiles:	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Inchikey:	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Pubchem:	10184653

Database

Identifier

Smiles:

CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Inchikey:

ULXXDDBFHOBEHA-CWDCEQMOSA-N

Pubchem:

Top molecular features associated with response to BIBW2992

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	OBSL1	FIMM	pan-cancer	AAC	0.39	0.01
mRNA	MSX1	FIMM	pan-cancer	AAC	-0.36	0.01
mRNA	MAPK8	FIMM	pan-cancer	AAC	0.37	0.01
mRNA	GLI1	FIMM	pan-cancer	AAC	-0.38	0.01
mRNA	KRT19	FIMM	pan-cancer	AAC	0.51	0.01
mRNA	GCNT1	FIMM	pan-cancer	AAC	-0.4	0.01
mRNA	LYPD3	FIMM	pan-cancer	AAC	0.42	0.01
mRNA	OCEL1	FIMM	pan-cancer	AAC	-0.4	0.01
mRNA	MAS1	FIMM	pan-cancer	AAC	-0.41	0.01
mRNA	CNTNAP1	FIMM	pan-cancer	AAC	-0.37	0.01