PharmacoDB

Sources

Names Used

Afatinib

BIBW2992

afatinib

PharmacoGx

BIBW2992

Database	Identifier
Smiles:	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Inchikey:	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Pubchem:	10184653

Database

Identifier

Smiles:

CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Inchikey:

ULXXDDBFHOBEHA-CWDCEQMOSA-N

Pubchem:

Top molecular features associated with response to BIBW2992

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	NDUFAF4	FIMM	pan-cancer	AAC	-0.38	0.01
mRNA	PLP2	FIMM	pan-cancer	AAC	-0.39	0.01
mRNA	NFYC	FIMM	pan-cancer	AAC	0.39	0.01
mRNA	LRIG2	FIMM	pan-cancer	AAC	0.36	0.01
mRNA	SUCO	FIMM	pan-cancer	AAC	0.43	0.01
mRNA	RAB32	FIMM	pan-cancer	AAC	-0.38	0.01
mRNA	PCOLCE	FIMM	pan-cancer	AAC	-0.38	0.01
mRNA	COPZ2	FIMM	pan-cancer	AAC	-0.36	0.01
mRNA	HIVEP3	FIMM	pan-cancer	AAC	0.47	0.01
mRNA	RPAP2	FIMM	pan-cancer	AAC	0.38	0.01