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BIBW2992

BIBW2992

Synonyms

Sources	Names Used
GDSC1000, FIMM	Afatinib
GRAY	BIBW2992
CTRPv2	afatinib
PharmacoGx	BIBW2992

External IDs

Database	Identifier
Smiles:	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Inchikey:	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Pubchem:	10184653

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to BIBW2992

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	RP11-347C12.3	CTRPv2	pan-cancer	AAC	0.16	1e-05
mRNA	NTMT1	CTRPv2	pan-cancer	AAC	-0.16	1e-05
mRNA	MISP	CTRPv2	pan-cancer	AAC	0.19	1e-05
mRNA	RBBP8NL	CTRPv2	pan-cancer	AAC	0.18	1e-05
mRNA	BTC	CTRPv2	pan-cancer	AAC	0.17	1e-05
mRNA	C1orf74	CTRPv2	pan-cancer	AAC	0.16	1e-05
mRNA	RP11-15K19.2	CTRPv2	pan-cancer	AAC	0.16	2e-05
mRNA	GPD1	CTRPv2	pan-cancer	AAC	0.16	2e-05
mRNA	CD46	CTRPv2	pan-cancer	AAC	0.17	2e-05
mRNA	S100A16	CTRPv2	pan-cancer	AAC	0.18	2e-05

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