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Bosutinib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMBosutinib
CTRPv2bosutinib
PharmacoGx Bosutinib

External IDs

DatabaseIdentifier
Smiles: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Inchikey: UBPYILGKFZZVDX-UHFFFAOYSA-N
Pubchem: 5328940

Annotated Targets

SRC, HCK, ABL1, BCR, CAMK1D, CAMK2G, CDK2, FRK, FYN, LYN, MAP2K1, MAP2K2, MAP3K2, MAP4K5, STK10, STK24, STK4, TNK2, TXK

FDA Approval Status

Approved
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Top molecular features associated with response to Bosutinib


Feature TypeStandardized
Nominal ANOVA
mRNA ANXA11 GDSC1000 pan-cancer AAC 0.095 0.01
mRNA DNAL1 CTRPv2 pan-cancer AAC -0.093 0.01
mRNA LIMS1 CTRPv2 pan-cancer AAC -0.091 0.01
mRNA MOCOS CTRPv2 pan-cancer AAC 0.092 0.01
mRNA OR11L1 CTRPv2 pan-cancer AAC 0.089 0.01
mRNA GPX8 GDSC1000 pan-cancer AAC 0.12 0.01
mRNA KLRB1 GDSC1000 pan-cancer AAC 0.085 0.01
mRNA SELENBP1 GDSC1000 pan-cancer AAC -0.095 0.01
mRNA C19orf33 CTRPv2 pan-cancer AAC 0.11 0.01
mRNA HACD4 CTRPv2 pan-cancer AAC 0.09 0.01
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