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Bosutinib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMBosutinib
CTRPv2bosutinib
PharmacoGx Bosutinib

External IDs

DatabaseIdentifier
Smiles: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Inchikey: UBPYILGKFZZVDX-UHFFFAOYSA-N
Pubchem: 5328940

Annotated Targets

SRC, HCK, ABL1, BCR, CAMK1D, CAMK2G, CDK2, FRK, FYN, LYN, MAP2K1, MAP2K2, MAP3K2, MAP4K5, STK10, STK24, STK4, TNK2, TXK

FDA Approval Status

Approved
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Top molecular features associated with response to Bosutinib


Feature TypeStandardized
Nominal ANOVA
mRNA THAP3 CTRPv2 pan-cancer AAC -0.089 0.01
mRNA EIF2AK1 CTRPv2 pan-cancer AAC 0.09 0.01
mRNA NCDN CTRPv2 pan-cancer AAC -0.093 0.01
mRNA GPRC6A GDSC1000 pan-cancer AAC -0.084 0.01
mRNA TRPC1 CTRPv2 pan-cancer AAC -0.1 0.01
mRNA C1S CTRPv2 pan-cancer AAC -0.09 0.01
mRNA RPS6KA1 CTRPv2 pan-cancer AAC 0.1 0.01
mRNA PDS5B CTRPv2 pan-cancer AAC 0.092 0.01
mRNA LTA4H GDSC1000 pan-cancer AAC 0.084 0.01
mRNA HLA-DQA1 GDSC1000 pan-cancer AAC -0.094 0.01
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