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Bosutinib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMBosutinib
CTRPv2bosutinib
PharmacoGx Bosutinib

External IDs

DatabaseIdentifier
Smiles: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Inchikey: UBPYILGKFZZVDX-UHFFFAOYSA-N
Pubchem: 5328940

Annotated Targets

SRC, HCK, ABL1, BCR, CAMK1D, CAMK2G, CDK2, FRK, FYN, LYN, MAP2K1, MAP2K2, MAP3K2, MAP4K5, STK10, STK24, STK4, TNK2, TXK

FDA Approval Status

Approved
Dataset Select
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Top molecular features associated with response to Bosutinib


Feature TypeStandardized
Nominal ANOVA
mRNA WFDC10A GDSC1000 pan-cancer AAC -0.083 0.01
mRNA CLRN2 GDSC1000 pan-cancer AAC 0.086 0.01
mRNA TMEM53 GDSC1000 pan-cancer AAC 0.088 0.01
mRNA SPAG8 GDSC1000 pan-cancer AAC -0.084 0.01
mRNA USP25 GDSC1000 pan-cancer AAC 0.087 0.01
mRNA ELP5 GDSC1000 pan-cancer AAC 0.087 0.01
mRNA GJA3 GDSC1000 pan-cancer AAC 0.087 0.01
mRNA ATG10 CTRPv2 pan-cancer AAC 0.086 0.01
mRNA TRIM14 CTRPv2 pan-cancer AAC 0.09 0.01
mRNA PPP1R2 GDSC1000 pan-cancer AAC -0.089 0.01
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