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Bosutinib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMBosutinib
CTRPv2bosutinib
PharmacoGx Bosutinib

External IDs

DatabaseIdentifier
Smiles: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Inchikey: UBPYILGKFZZVDX-UHFFFAOYSA-N
Pubchem: 5328940

Annotated Targets

SRC, HCK, ABL1, BCR, CAMK1D, CAMK2G, CDK2, FRK, FYN, LYN, MAP2K1, MAP2K2, MAP3K2, MAP4K5, STK10, STK24, STK4, TNK2, TXK

FDA Approval Status

Approved
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Top molecular features associated with response to Bosutinib


Feature TypeStandardized
Nominal ANOVA
mRNA MAGI2 CTRPv2 pan-cancer AAC -0.091 0.01
mRNA CNKSR2 FIMM pan-cancer AAC 0.64 0.01
mRNA ABLIM3 CTRPv2 pan-cancer AAC -0.095 0.01
mRNA RGS10 FIMM pan-cancer AAC 0.61 0.01
mRNA RWDD1 FIMM pan-cancer AAC 0.83 0.01
mRNA CCT5 GDSC1000 pan-cancer AAC 0.086 0.01
mRNA SIRPG GDSC1000 pan-cancer AAC 0.083 0.01
mRNA TMBIM1 GDSC1000 pan-cancer AAC 0.1 0.01
mRNA ATP8B2 CTRPv2 pan-cancer AAC -0.091 0.01
mRNA ST3GAL6 GDSC1000 pan-cancer AAC -0.1 0.01
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