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Bosutinib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMBosutinib
CTRPv2bosutinib
PharmacoGx Bosutinib

External IDs

DatabaseIdentifier
Smiles: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Inchikey: UBPYILGKFZZVDX-UHFFFAOYSA-N
Pubchem: 5328940

Annotated Targets

SRC, HCK, ABL1, BCR, CAMK1D, CAMK2G, CDK2, FRK, FYN, LYN, MAP2K1, MAP2K2, MAP3K2, MAP4K5, STK10, STK24, STK4, TNK2, TXK

FDA Approval Status

Approved
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Top molecular features associated with response to Bosutinib


Feature TypeStandardized
Nominal ANOVA
mRNA GMFG CTRPv2 pan-cancer AAC 0.18 0.0002
mRNA GDF2 CTRPv2 pan-cancer AAC 0.12 0.0002
mRNA TMEM183A FIMM pan-cancer AAC 0.76 0.0002
mRNA SCARB2 CTRPv2 pan-cancer AAC -0.14 0.0002
mRNA SCAMP5 GDSC1000 pan-cancer AAC -0.13 0.0002
mRNA PLS1 GDSC1000 pan-cancer AAC 0.15 0.0002
mRNA RIMKLB CTRPv2 pan-cancer AAC 0.13 0.0002
mRNA PHGDH GDSC1000 pan-cancer AAC 0.12 0.0002
mRNA SDHAF1 GDSC1000 pan-cancer AAC -0.13 0.0002
mRNA TNFAIP8 GDSC1000 pan-cancer AAC 0.16 0.0002
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