PharmacoDB

Sources

Names Used

Temsirolimus

temsirolimus

PharmacoGx

temsirolimus

Database	Identifier
Smiles:	CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC
Inchikey:	CBPNZQVSJQDFBE-FUXHJELOSA-N
Pubchem:	6918289

Database

Identifier

Smiles:

CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC

Inchikey:

CBPNZQVSJQDFBE-FUXHJELOSA-N

Pubchem:

Top molecular features associated with response to temsirolimus

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	RTTN	CTRPv2	pan-cancer	AAC	0.18	0.0003
mRNA	SH3BGRL2	GDSC1000	pan-cancer	AAC	-0.15	0.0003
mRNA	COL5A2	GDSC1000	pan-cancer	AAC	0.14	0.0003
mRNA	KIAA1211L	GDSC1000	pan-cancer	AAC	-0.14	0.0003
mRNA	CASP3	GDSC1000	pan-cancer	AAC	0.13	0.0003
mRNA	AFDN	GDSC1000	pan-cancer	AAC	-0.13	0.0003
mRNA	LAPTM4B	GDSC1000	pan-cancer	AAC	-0.18	0.0003
mRNA	FAM155B	GDSC1000	pan-cancer	AAC	-0.12	0.0003
mRNA	PYHIN1	GDSC1000	pan-cancer	AAC	0.13	0.0003
mRNA	STXBP5L	GDSC1000	pan-cancer	AAC	-0.13	0.0003