PharmacoDB

Sources

Names Used

Temsirolimus

temsirolimus

PharmacoGx

temsirolimus

Database	Identifier
Smiles:	CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC
Inchikey:	CBPNZQVSJQDFBE-FUXHJELOSA-N
Pubchem:	6918289

Database

Identifier

Smiles:

CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC

Inchikey:

CBPNZQVSJQDFBE-FUXHJELOSA-N

Pubchem:

Top molecular features associated with response to temsirolimus

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	RECQL	GDSC1000	pan-cancer	AAC	0.15	1e-05
mRNA	LDAH	GDSC1000	pan-cancer	AAC	0.17	1e-05
mRNA	GRHPR	GDSC1000	pan-cancer	AAC	0.15	1e-05
mRNA	IL21R	CTRPv2	pan-cancer	AAC	0.22	1e-05
mRNA	SLC6A16	CTRPv2	pan-cancer	AAC	0.21	1e-05
mRNA	MRPL19	GDSC1000	pan-cancer	AAC	0.14	2e-05
mRNA	GNG4	GDSC1000	pan-cancer	AAC	-0.17	2e-05
mRNA	CDC27	GDSC1000	pan-cancer	AAC	0.15	2e-05
mRNA	RAP1A	GDSC1000	pan-cancer	AAC	0.16	2e-05
mRNA	BMF	CTRPv2	pan-cancer	AAC	0.21	2e-05