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Methotrexate

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMMethotrexate
CTRPv2methotrexate
PharmacoGx Methotrexate

External IDs

DatabaseIdentifier
Smiles: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Inchikey: FBOZXECLQNJBKD-ZDUSSCGKSA-N
Pubchem: 126941

Annotated Targets

DHFR

FDA Approval Status

Approved
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Top molecular features associated with response to Methotrexate


Feature TypeStandardized
Nominal ANOVA
mRNA RHOC GDSC1000 pan-cancer AAC -0.12 0.0004
mRNA LDOC1L GDSC1000 pan-cancer AAC 0.12 0.0004
mRNA THAP9 GDSC1000 pan-cancer AAC 0.11 0.0004
mRNA RP11-894J14.5 CTRPv2 pan-cancer AAC 0.14 0.0004
mRNA KIF21B CTRPv2 pan-cancer AAC 0.15 0.0004
mRNA AC023908.1 CTRPv2 pan-cancer AAC -0.14 0.0004
mRNA ZRANB3 CTRPv2 pan-cancer AAC 0.13 0.0004
mRNA BLMH CTRPv2 pan-cancer AAC 0.14 0.0004
mRNA ADAMTSL1 CTRPv2 pan-cancer AAC -0.14 0.0004
mRNA CDC5L CTRPv2 pan-cancer AAC 0.13 0.0004
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