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Methotrexate

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMMethotrexate
CTRPv2methotrexate
PharmacoGx Methotrexate

External IDs

DatabaseIdentifier
Smiles: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Inchikey: FBOZXECLQNJBKD-ZDUSSCGKSA-N
Pubchem: 126941

Annotated Targets

DHFR

FDA Approval Status

Approved
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Top molecular features associated with response to Methotrexate


Feature TypeStandardized
Nominal ANOVA
mRNA KIF14 CTRPv2 pan-cancer AAC 0.22 2e-09
mRNA SMAD7 CTRPv2 pan-cancer AAC -0.23 2e-09
mRNA RP11-321N4.5 CTRPv2 pan-cancer AAC 0.22 2e-09
mRNA NUP88 CTRPv2 pan-cancer AAC 0.22 2e-09
mRNA SRSF1 CTRPv2 pan-cancer AAC 0.23 3e-09
mRNA DDX21 CTRPv2 pan-cancer AAC 0.22 3e-09
mRNA PFAS CTRPv2 pan-cancer AAC 0.23 3e-09
mRNA DAZAP1 CTRPv2 pan-cancer AAC 0.26 3e-09
mRNA SNRPD1 CTRPv2 pan-cancer AAC 0.23 3e-09
mRNA GTPBP4 CTRPv2 pan-cancer AAC 0.22 4e-09
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