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Methotrexate

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMMethotrexate
CTRPv2methotrexate
PharmacoGx Methotrexate

External IDs

DatabaseIdentifier
Smiles: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Inchikey: FBOZXECLQNJBKD-ZDUSSCGKSA-N
Pubchem: 126941

Annotated Targets

DHFR

FDA Approval Status

Approved
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Top molecular features associated with response to Methotrexate


Feature TypeStandardized
Nominal ANOVA
mRNA LIAS CTRPv2 pan-cancer AAC 0.17 1e-05
mRNA ARHGAP15 GDSC1000 pan-cancer AAC 0.29 1e-05
mRNA FAM175A GDSC1000 pan-cancer AAC 0.14 1e-05
mRNA ORC6 CTRPv2 pan-cancer AAC 0.16 1e-05
mRNA GSN CTRPv2 pan-cancer AAC -0.17 1e-05
mRNA LSM2 CTRPv2 pan-cancer AAC 0.17 1e-05
mRNA BCS1L GDSC1000 pan-cancer AAC 0.13 1e-05
mRNA PPP1R1A GDSC1000 pan-cancer AAC 0.15 1e-05
mRNA MSH5 CTRPv2 pan-cancer AAC 0.19 1e-05
mRNA PSTPIP1 GDSC1000 pan-cancer AAC 0.15 1e-05
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