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Methotrexate

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMMethotrexate
CTRPv2methotrexate
PharmacoGx Methotrexate

External IDs

DatabaseIdentifier
Smiles: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Inchikey: FBOZXECLQNJBKD-ZDUSSCGKSA-N
Pubchem: 126941

Annotated Targets

DHFR

FDA Approval Status

Approved
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Top molecular features associated with response to Methotrexate


Feature TypeStandardized
Nominal ANOVA
mRNA CNOT6 GDSC1000 pan-cancer AAC 0.15 1e-06
mRNA MYB GDSC1000 pan-cancer AAC 0.22 1e-06
mRNA CKAP2 CTRPv2 pan-cancer AAC 0.18 1e-06
mRNA RIF1 CTRPv2 pan-cancer AAC 0.18 1e-06
mRNA CDC27 CTRPv2 pan-cancer AAC 0.18 1e-06
mRNA HSPE1-MOB4 CTRPv2 pan-cancer AAC 0.18 1e-06
mRNA EWSR1 CTRPv2 pan-cancer AAC 0.19 1e-06
mRNA PHF14 GDSC1000 pan-cancer AAC 0.15 1e-06
mRNA VRK1 CTRPv2 pan-cancer AAC 0.21 1e-06
mRNA TMEM206 GDSC1000 pan-cancer AAC 0.15 1e-06
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