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Methotrexate

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMMethotrexate
CTRPv2methotrexate
PharmacoGx Methotrexate

External IDs

DatabaseIdentifier
Smiles: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Inchikey: FBOZXECLQNJBKD-ZDUSSCGKSA-N
Pubchem: 126941

Annotated Targets

DHFR

FDA Approval Status

Approved
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Top molecular features associated with response to Methotrexate


Feature TypeStandardized
Nominal ANOVA
mRNA DHODH CTRPv2 pan-cancer AAC 0.2 5e-08
mRNA RFC4 CTRPv2 pan-cancer AAC 0.2 6e-08
mRNA PALLD CTRPv2 pan-cancer AAC -0.22 6e-08
mRNA RTN4IP1 CTRPv2 pan-cancer AAC 0.2 6e-08
mRNA FOXN2 CTRPv2 pan-cancer AAC 0.21 6e-08
mRNA EIF5A CTRPv2 pan-cancer AAC 0.2 6e-08
mRNA RFXAP CTRPv2 pan-cancer AAC 0.23 6e-08
mRNA TMEM177 CTRPv2 pan-cancer AAC 0.2 6e-08
mRNA ATP6V0E1 CTRPv2 pan-cancer AAC -0.23 6e-08
mRNA SKA3 CTRPv2 pan-cancer AAC 0.2 7e-08
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