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ibrutinib

ibrutinib

Synonyms

Sources	Names Used
CTRPv2	ibrutinib
PharmacoGx	ibrutinib

External IDs

Database	Identifier
Smiles:	Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Pubchem:	24821094

Annotated Targets

BLK, BMX, BTK

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to ibrutinib

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	IRF8	CTRPv2	pan-cancer	AAC	0.23	9e-07
mRNA	SWAP70	CTRPv2	pan-cancer	AAC	0.21	9e-07
mRNA	LAD1	CTRPv2	pan-cancer	AAC	0.25	9e-07
mRNA	NLRP7	CTRPv2	pan-cancer	AAC	0.2	9e-07
mRNA	MYADML2	CTRPv2	pan-cancer	AAC	0.2	9e-07
mRNA	RP11-296A16.1	CTRPv2	pan-cancer	AAC	0.2	1e-06
mRNA	GRAP	CTRPv2	pan-cancer	AAC	0.22	1e-06
mRNA	PGAP3	CTRPv2	pan-cancer	AAC	0.21	1e-06
mRNA	TRPM4	CTRPv2	pan-cancer	AAC	0.22	1e-06
mRNA	EMP3	CTRPv2	pan-cancer	AAC	-0.23	1e-06

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