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ibrutinib

ibrutinib

Synonyms

Sources	Names Used
CTRPv2	ibrutinib
PharmacoGx	ibrutinib

External IDs

Database	Identifier
Smiles:	Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Pubchem:	24821094

Annotated Targets

BLK, BMX, BTK

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to ibrutinib

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CTD-2545M3.6	CTRPv2	pan-cancer	AAC	0.2	4e-06
mRNA	SEMA3D	CTRPv2	pan-cancer	AAC	0.19	4e-06
mRNA	SPDEF	CTRPv2	pan-cancer	AAC	0.26	4e-06
mRNA	PLXNB2	CTRPv2	pan-cancer	AAC	0.2	5e-06
mRNA	MED1	CTRPv2	pan-cancer	AAC	0.2	5e-06
mRNA	TAS2R14	CTRPv2	pan-cancer	AAC	-0.19	5e-06
mRNA	RPL19	CTRPv2	pan-cancer	AAC	0.2	5e-06
mRNA	SLC36A2	CTRPv2	pan-cancer	AAC	0.18	5e-06
mRNA	MEF2B	CTRPv2	pan-cancer	AAC	0.2	5e-06
mRNA	PTAFR	CTRPv2	pan-cancer	AAC	0.2	5e-06

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