About
Documentation
Cite Us!
Github
Download
News
Explore
Batch Query
Search
Site
Home
About
Documentation
PharmacoGx
Cite Us!
Tools
Explore
Batch Query
Search
GitHub
Datatypes
datasets
cell lines
tissues
drugs
genes
experiments
Home
/
Compounds
/
ibrutinib
ibrutinib
Synonyms
Sources
Names Used
CTRPv2
ibrutinib
PharmacoGx
ibrutinib
External IDs
Database
Identifier
Smiles:
Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Pubchem:
24821094
Annotated Targets
BLK
,
BMX
,
BTK
FDA Approval Status
Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with ibrutinib
(per dataset)
0
50
100
150
200
250
300
350
400
450
500
550
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
597
Download SVG
Number of tissues tested with ibrutinib
(per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
23
Download SVG
Dataset Select
all
CTRPv2
ibrutinib: AAC
AAC
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
RI-1
RI-1
SU-DHL-6
SU-DHL-6
TE 617.T
TE 617.T
EFM-192A
EFM-192A
AM-38
AM-38
AU565
AU565
SCC-25
SCC-25
SK-BR-3
SK-BR-3
ZR-75-30
ZR-75-30
HCC4006
HCC4006
CCK-81
CCK-81
EPLC-272H
EPLC-272H
NCC-StC-K140
NCC-StC-K140
Pfeiffer
Pfeiffer
HCC1419
HCC1419
42-MG-BA
42-MG-BA
EoL-1-cell
EoL-1-cell
OE21
OE21
SCaBER
SCaBER
SNU-216
SNU-216
PC-14
PC-14
COR-L105
COR-L105
Gp2D
Gp2D
CW-2
CW-2
U-BLC1
U-BLC1
GA-10
GA-10
Hs 611.T
Hs 611.T
TE-15
TE-15
NCI-H2170
NCI-H2170
BICR 56
BICR 56
HT-1080
HT-1080
NCI-H226
NCI-H226
YKG-1
YKG-1
OCI-M1
OCI-M1
JL-1
JL-1
KP-N-YN
KP-N-YN
SNU-869
SNU-869
YH-13
YH-13
Hs 688(A).T
Hs 688(A).T
U-118-MG
U-118-MG
RKN
RKN
JHH-6
JHH-6
PANC-1
PANC-1
NCI-H1339
NCI-H1339
Calu-1
Calu-1
SH-10-TC
SH-10-TC
PC-3
PC-3
AsPC-1
AsPC-1
8-MG-BA
8-MG-BA
TT2609-C02
TT2609-C02
PA-TU-8902
PA-TU-8902
EFO-21
EFO-21
Panc 04.03
Panc 04.03
TCC-PAN2
TCC-PAN2
Panc 02.03
Panc 02.03
IPC-298
IPC-298
KNS-62
KNS-62
YAPC
YAPC
KARPAS-620
KARPAS-620
NCI-H460
NCI-H460
RI-1
SU-DHL-6
TE 617.T
EFM-192A
AM-38
AU565
SCC-25
SK-BR-3
ZR-75-30
HCC4006
CCK-81
EPLC-272H
NCC-StC-K140
Pfeiffer
HCC1419
42-MG-BA
EoL-1-cell
OE21
SCaBER
SNU-216
PC-14
COR-L105
Gp2D
CW-2
U-BLC1
GA-10
Hs 611.T
TE-15
NCI-H2170
BICR 56
HT-1080
NCI-H226
YKG-1
OCI-M1
JL-1
KP-N-YN
SNU-869
YH-13
Hs 688(A).T
U-118-MG
RKN
JHH-6
PANC-1
NCI-H1339
Calu-1
SH-10-TC
PC-3
AsPC-1
8-MG-BA
TT2609-C02
PA-TU-8902
EFO-21
Panc 04.03
TCC-PAN2
Panc 02.03
IPC-298
KNS-62
YAPC
KARPAS-620
NCI-H460
RI-1: 0.70
Synonyms: RI-1, RI1
SU-DHL-6: 0.68
Synonyms: SU-DHL-6, SUDHL6
TE 617.T: 0.67
Synonyms: TE 617.T, TE_617.T, TE617T
EFM-192A: 0.66
Synonyms: EFM-192A, EFM192A, efm192a
AM-38: 0.66
Synonyms: AM-38, AM38
AU565: 0.62
Synonyms: AU565, au565
SCC-25: 0.60
Synonyms: SCC-25, SCC25
SK-BR-3: 0.60
Synonyms: SK-BR-3, SKBR3, skbr3
ZR-75-30: 0.59
Synonyms: ZR-75-30, ZR7530, zr7530
HCC4006: 0.57
Synonyms: HCC4006
CCK-81: 0.56
Synonyms: CCK-81, CCK81
EPLC-272H: 0.55
Synonyms: EPLC-272H, EPLC272H
NCC-StC-K140: 0.54
Synonyms: NCC-StC-K140, NCCSTCK140
Pfeiffer: 0.53
Synonyms: Pfeiffer, PFEIFFER
HCC1419: 0.51
Synonyms: HCC1419, hcc1419
42-MG-BA: 0.51
Synonyms: 42-MG-BA, 42MGBA
EoL-1-cell: 0.50
Synonyms: EoL-1-cell, EOL-1, EOL1
OE21: 0.50
Synonyms: OE21
SCaBER: 0.50
Synonyms: SCaBER, SCABER
SNU-216: 0.49
Synonyms: SNU-216, SNU216
PC-14: 0.48
Synonyms: PC-14, PC14
COR-L105: 0.48
Synonyms: COR-L105, CORL105
Gp2D: 0.48
Synonyms: Gp2D, GP2d, GP2D
CW-2: 0.47
Synonyms: CW-2, CW2
U-BLC1: 0.46
Synonyms: U-BLC1, UBLC1
GA-10: 0.46
Synonyms: GA-10, GA10
Hs 611.T: 0.45
Synonyms: Hs 611.T, Hs_611.T, HS611T
TE-15: 0.45
Synonyms: TE-15, TE15
NCI-H2170: 0.45
Synonyms: NCI-H2170, NCIH2170
BICR 56: 0.44
Synonyms: BICR 56, BICR_56, BICR56
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
HT-1080: 0.03
Synonyms: HT-1080, HT1080
NCI-H226: 0.03
Synonyms: NCI-H226, NCIH226
YKG-1: 0.03
Synonyms: YKG-1, YKG1
OCI-M1: 0.03
Synonyms: OCI-M1, OCIM1
JL-1: 0.03
Synonyms: JL-1, JL1
KP-N-YN: 0.03
Synonyms: KP-N-YN, KPNYN
SNU-869: 0.03
Synonyms: SNU-869, SNU869
YH-13: 0.03
Synonyms: YH-13, YH13
Hs 688(A).T: 0.03
Synonyms: Hs 688(A).T, Hs_688_A_.T, HS688AT
U-118-MG: 0.03
Synonyms: U-118-MG, U-118 MG, U-118_MG, U118MG
RKN: 0.03
Synonyms: RKN
JHH-6: 0.03
Synonyms: JHH-6, JHH6
PANC-1: 0.03
Synonyms: PANC-1, PANC1
NCI-H1339: 0.03
Synonyms: NCI-H1339, NCIH1339
Calu-1: 0.03
Synonyms: Calu-1, CALU1
SH-10-TC: 0.03
Synonyms: SH-10-TC, SH10TC
PC-3: 0.02
Synonyms: PC-3, PC3
AsPC-1: 0.02
Synonyms: AsPC-1, ASPC1
8-MG-BA: 0.02
Synonyms: 8-MG-BA, 8MGBA
TT2609-C02: 0.02
Synonyms: TT2609-C02, TT2609C02
PA-TU-8902: 0.02
Synonyms: PA-TU-8902, PATU8902
EFO-21: 0.02
Synonyms: EFO-21, EFO21
Panc 04.03: 0.02
Synonyms: Panc 04.03, Panc_04.03, PANC-04-03, PANC0403
TCC-PAN2: 0.02
Synonyms: TCC-PAN2, TCCPAN2
Panc 02.03: 0.02
Synonyms: Panc 02.03, Panc_02.03, PANC-02-03, PANC0203
IPC-298: 0.02
Synonyms: IPC-298, IPC298
KNS-62: 0.01
Synonyms: KNS-62, KNS62
YAPC: 0.01
Synonyms: YAPC
KARPAS-620: 0.01
Synonyms: KARPAS-620, KARPAS620
NCI-H460: 0.01
Synonyms: NCI-H460, NCIH460
Download SVG
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
5.00
PK-45H
PK-45H
RERF-LC-Ad2
RERF-LC-Ad2
NCI-H2052
NCI-H2052
OCI-LY-19
OCI-LY-19
SNU-601
SNU-601
DBTRG-05MG
DBTRG-05MG
PK-1
PK-1
SK-OV-3
SK-OV-3
NCI-H460
NCI-H460
Panc 08.13
Panc 08.13
PA-TU-8902
PA-TU-8902
KYSE-70
KYSE-70
ZR-75-1
ZR-75-1
COV644
COV644
RCM-1
RCM-1
K029AX
K029AX
OVCAR-8
OVCAR-8
MEL-JUSO
MEL-JUSO
KARPAS-620
KARPAS-620
NCI-H2172
NCI-H2172
SW1573
SW1573
LU-65
LU-65
Caki-2
Caki-2
WM-793
WM-793
KNS-62
KNS-62
OE33
OE33
EFO-21
EFO-21
KP-N-YN
KP-N-YN
IPC-298
IPC-298
Panc 02.03
Panc 02.03
HCC2935
HCC2935
CW-2
CW-2
U-CH1
U-CH1
GA-10
GA-10
EKVX
EKVX
Gp2D
Gp2D
BICR 56
BICR 56
EoL-1-cell
EoL-1-cell
COR-L105
COR-L105
42-MG-BA
42-MG-BA
Pfeiffer
Pfeiffer
PC-14
PC-14
SNU-216
SNU-216
OE21
OE21
U-BLC1
U-BLC1
SCaBER
SCaBER
HCC4006
HCC4006
EPLC-272H
EPLC-272H
NCI-H2170
NCI-H2170
HCC1419
HCC1419
CCK-81
CCK-81
NCC-StC-K140
NCC-StC-K140
SCC-25
SCC-25
AU565
AU565
TE 617.T
TE 617.T
SK-BR-3
SK-BR-3
ZR-75-30
ZR-75-30
EFM-192A
EFM-192A
AM-38
AM-38
SU-DHL-6
SU-DHL-6
PK-45H
RERF-LC-Ad2
NCI-H2052
OCI-LY-19
SNU-601
DBTRG-05MG
PK-1
SK-OV-3
NCI-H460
Panc 08.13
PA-TU-8902
KYSE-70
ZR-75-1
COV644
RCM-1
K029AX
OVCAR-8
MEL-JUSO
KARPAS-620
NCI-H2172
SW1573
LU-65
Caki-2
WM-793
KNS-62
OE33
EFO-21
KP-N-YN
IPC-298
Panc 02.03
HCC2935
CW-2
U-CH1
GA-10
EKVX
Gp2D
BICR 56
EoL-1-cell
COR-L105
42-MG-BA
Pfeiffer
PC-14
SNU-216
OE21
U-BLC1
SCaBER
HCC4006
EPLC-272H
NCI-H2170
HCC1419
CCK-81
NCC-StC-K140
SCC-25
AU565
TE 617.T
SK-BR-3
ZR-75-30
EFM-192A
AM-38
SU-DHL-6
PK-45H: 5.78 (log10 µM)
Synonyms: PK-45H, PK45H
RERF-LC-Ad2: 4.91 (log10 µM)
Synonyms: RERF-LC-Ad2, RERFLCAD2
NCI-H2052: 3.62 (log10 µM)
Synonyms: NCI-H2052, NCIH2052
OCI-LY-19: 3.31 (log10 µM)
Synonyms: OCI-LY-19, OCILY19
SNU-601: 2.95 (log10 µM)
Synonyms: SNU-601, SNU601
DBTRG-05MG: 2.76 (log10 µM)
Synonyms: DBTRG-05MG, DBTRG05MG
PK-1: 2.66 (log10 µM)
Synonyms: PK-1, PK1
SK-OV-3: 2.65 (log10 µM)
Synonyms: SK-OV-3, SKOV3
NCI-H460: 2.52 (log10 µM)
Synonyms: NCI-H460, NCIH460
Panc 08.13: 2.46 (log10 µM)
Synonyms: Panc 08.13, Panc_08.13, PANC-08-13, PANC0813
PA-TU-8902: 2.35 (log10 µM)
Synonyms: PA-TU-8902, PATU8902
KYSE-70: 2.28 (log10 µM)
Synonyms: KYSE-70, KYSE70
ZR-75-1: 2.27 (log10 µM)
Synonyms: ZR-75-1, ZR751, zr751
COV644: 2.17 (log10 µM)
Synonyms: COV644
RCM-1: 2.12 (log10 µM)
Synonyms: RCM-1, RCM1
K029AX: 2.11 (log10 µM)
Synonyms: K029AX
OVCAR-8: 2.04 (log10 µM)
Synonyms: OVCAR-8, OVCAR8
MEL-JUSO: 2.02 (log10 µM)
Synonyms: MEL-JUSO, MELJUSO
KARPAS-620: 1.97 (log10 µM)
Synonyms: KARPAS-620, KARPAS620
NCI-H2172: 1.97 (log10 µM)
Synonyms: NCI-H2172, NCIH2172
SW1573: 1.93 (log10 µM)
Synonyms: SW1573, SW 1573, SW_1573
LU-65: 1.93 (log10 µM)
Synonyms: LU-65, LU65
Caki-2: 1.93 (log10 µM)
Synonyms: Caki-2, CAKI2
WM-793: 1.88 (log10 µM)
Synonyms: WM-793, WM793B, WM793
KNS-62: 1.87 (log10 µM)
Synonyms: KNS-62, KNS62
OE33: 1.87 (log10 µM)
Synonyms: OE33
EFO-21: 1.86 (log10 µM)
Synonyms: EFO-21, EFO21
KP-N-YN: 1.85 (log10 µM)
Synonyms: KP-N-YN, KPNYN
IPC-298: 1.83 (log10 µM)
Synonyms: IPC-298, IPC298
Panc 02.03: 1.82 (log10 µM)
Synonyms: Panc 02.03, Panc_02.03, PANC-02-03, PANC0203
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
HCC2935: -0.16 (log10 µM)
Synonyms: HCC2935
CW-2: -0.22 (log10 µM)
Synonyms: CW-2, CW2
U-CH1: -0.23 (log10 µM)
Synonyms: U-CH1
GA-10: -0.24 (log10 µM)
Synonyms: GA-10, GA10
EKVX: -0.28 (log10 µM)
Synonyms: EKVX
Gp2D: -0.30 (log10 µM)
Synonyms: Gp2D, GP2d, GP2D
BICR 56: -0.43 (log10 µM)
Synonyms: BICR 56, BICR_56, BICR56
EoL-1-cell: -0.49 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
COR-L105: -0.49 (log10 µM)
Synonyms: COR-L105, CORL105
42-MG-BA: -0.56 (log10 µM)
Synonyms: 42-MG-BA, 42MGBA
Pfeiffer: -0.64 (log10 µM)
Synonyms: Pfeiffer, PFEIFFER
PC-14: -0.68 (log10 µM)
Synonyms: PC-14, PC14
SNU-216: -0.70 (log10 µM)
Synonyms: SNU-216, SNU216
OE21: -0.71 (log10 µM)
Synonyms: OE21
U-BLC1: -0.72 (log10 µM)
Synonyms: U-BLC1, UBLC1
SCaBER: -0.81 (log10 µM)
Synonyms: SCaBER, SCABER
HCC4006: -0.85 (log10 µM)
Synonyms: HCC4006
EPLC-272H: -0.88 (log10 µM)
Synonyms: EPLC-272H, EPLC272H
NCI-H2170: -0.88 (log10 µM)
Synonyms: NCI-H2170, NCIH2170
HCC1419: -0.92 (log10 µM)
Synonyms: HCC1419, hcc1419
CCK-81: -0.93 (log10 µM)
Synonyms: CCK-81, CCK81
NCC-StC-K140: -1.01 (log10 µM)
Synonyms: NCC-StC-K140, NCCSTCK140
SCC-25: -1.16 (log10 µM)
Synonyms: SCC-25, SCC25
AU565: -1.36 (log10 µM)
Synonyms: AU565, au565
TE 617.T: -1.58 (log10 µM)
Synonyms: TE 617.T, TE_617.T, TE617T
SK-BR-3: -1.89 (log10 µM)
Synonyms: SK-BR-3, SKBR3, skbr3
ZR-75-30: -1.91 (log10 µM)
Synonyms: ZR-75-30, ZR7530, zr7530
EFM-192A: -1.95 (log10 µM)
Synonyms: EFM-192A, EFM192A, efm192a
AM-38: -3.07 (log10 µM)
Synonyms: AM-38, AM38
SU-DHL-6: -3.54 (log10 µM)
Synonyms: SU-DHL-6, SUDHL6
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
ibrutinib: AAC
AAC
Tissues
0.10
0.20
0.30
0.40
0.50
0.60
0.70
cervix
cervix
pancreas
pancreas
thyroid
thyroid
pleura
pleura
prostate
prostate
bone
bone
skin
skin
central_nervous_system
central_nervous_system
endometrium
endometrium
autonomic_ganglia
autonomic_ganglia
ovary
ovary
kidney
kidney
liver
liver
lung
lung
urinary_tract
urinary_tract
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
soft_tissue
soft_tissue
stomach
stomach
unknown
unknown
large_intestine
large_intestine
breast
breast
oesophagus
oesophagus
upper_aerodigestive_tract
upper_aerodigestive_tract
-5.00
-4.00
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
oesophagus
oesophagus
cervix
cervix
upper_aerodigestive_tract
upper_aerodigestive_tract
breast
breast
unknown
unknown
soft_tissue
soft_tissue
stomach
stomach
large_intestine
large_intestine
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
urinary_tract
urinary_tract
lung
lung
liver
liver
autonomic_ganglia
autonomic_ganglia
kidney
kidney
endometrium
endometrium
central_nervous_system
central_nervous_system
ovary
ovary
skin
skin
prostate
prostate
bone
bone
thyroid
thyroid
pleura
pleura
pancreas
pancreas
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to ibrutinib
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
NXPE3
CTRPv2
pan-cancer
AAC
-0.15
0.0007
mRNA
FAM217A
CTRPv2
pan-cancer
AAC
0.14
0.0007
mRNA
MAP4K1
CTRPv2
pan-cancer
AAC
0.19
0.0007
mRNA
BNIP3L
CTRPv2
pan-cancer
AAC
-0.15
0.0007
mRNA
MSRA
CTRPv2
pan-cancer
AAC
-0.15
0.0007
mRNA
FAM81A
CTRPv2
pan-cancer
AAC
0.14
0.0007
mRNA
RGPD8
CTRPv2
pan-cancer
AAC
-0.15
0.0007
mRNA
LRRC49
CTRPv2
pan-cancer
AAC
-0.16
0.0007
mRNA
SIT1
CTRPv2
pan-cancer
AAC
0.15
0.0007
mRNA
WDR66
CTRPv2
pan-cancer
AAC
0.14
0.0007
← Previous
1
2
…
33
34
35
…
199
200
Next →
Download CSV