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ibrutinib

ibrutinib

Synonyms

Sources	Names Used
CTRPv2	ibrutinib
PharmacoGx	ibrutinib

External IDs

Database	Identifier
Smiles:	Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Pubchem:	24821094

Annotated Targets

BLK, BMX, BTK

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to ibrutinib

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MFSD4A	CTRPv2	pan-cancer	AAC	0.14	0.0008
mRNA	RP4-777O23.3	CTRPv2	pan-cancer	AAC	0.15	0.0008
mRNA	TMEM62	CTRPv2	pan-cancer	AAC	0.15	0.0009
mRNA	TOR1A	CTRPv2	pan-cancer	AAC	-0.14	0.0009
mRNA	YIPF1	CTRPv2	pan-cancer	AAC	0.14	0.0009
mRNA	ADGRL3	CTRPv2	pan-cancer	AAC	0.14	0.0009
mRNA	TRAPPC6A	CTRPv2	pan-cancer	AAC	0.15	0.0009
mRNA	ZFYVE28	CTRPv2	pan-cancer	AAC	-0.14	0.0009
mRNA	IL6ST	CTRPv2	pan-cancer	AAC	-0.15	0.0009
mRNA	SH2B2	CTRPv2	pan-cancer	AAC	0.15	0.0009

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