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ibrutinib

ibrutinib

Synonyms

Sources	Names Used
CTRPv2	ibrutinib
PharmacoGx	ibrutinib

External IDs

Database	Identifier
Smiles:	Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Pubchem:	24821094

Annotated Targets

BLK, BMX, BTK

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to ibrutinib

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MYH11	CTRPv2	pan-cancer	AAC	0.14	0.0006
mRNA	CDK17	CTRPv2	pan-cancer	AAC	-0.14	0.0006
mRNA	AKAP13	CTRPv2	pan-cancer	AAC	0.15	0.0006
mRNA	PHC2	CTRPv2	pan-cancer	AAC	-0.15	0.0006
mRNA	SLC43A2	CTRPv2	pan-cancer	AAC	0.14	0.0006
mRNA	LA16c-431H6.6	CTRPv2	pan-cancer	AAC	0.14	0.0006
mRNA	TECRL	CTRPv2	pan-cancer	AAC	0.14	0.0006
mRNA	HIST1H2BK	CTRPv2	pan-cancer	AAC	0.14	0.0006
mRNA	KMO	CTRPv2	pan-cancer	AAC	0.15	0.0006
mRNA	PHF24	CTRPv2	pan-cancer	AAC	0.14	0.0006

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