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ibrutinib

ibrutinib

Synonyms

Sources	Names Used
CTRPv2	ibrutinib
PharmacoGx	ibrutinib

External IDs

Database	Identifier
Smiles:	Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Pubchem:	24821094

Annotated Targets

BLK, BMX, BTK

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to ibrutinib

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	GRAPL	CTRPv2	pan-cancer	AAC	0.17	0.0001
mRNA	CREB3L4	CTRPv2	pan-cancer	AAC	0.2	0.0001
mRNA	IKZF3	CTRPv2	pan-cancer	AAC	0.18	0.0001
mRNA	CAMK2G	CTRPv2	pan-cancer	AAC	0.16	0.0001
mRNA	B3GALT4	CTRPv2	pan-cancer	AAC	0.17	0.0002
mRNA	TTC22	CTRPv2	pan-cancer	AAC	0.17	0.0002
mRNA	RP13-347D8.7	CTRPv2	pan-cancer	AAC	0.15	0.0002
mRNA	ARRDC1	CTRPv2	pan-cancer	AAC	0.19	0.0002
mRNA	EPHA7	CTRPv2	pan-cancer	AAC	0.16	0.0002
mRNA	SPG20	CTRPv2	pan-cancer	AAC	-0.18	0.0002

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