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ibrutinib

ibrutinib

Synonyms

Sources	Names Used
CTRPv2	ibrutinib
PharmacoGx	ibrutinib

External IDs

Database	Identifier
Smiles:	Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Pubchem:	24821094

Annotated Targets

BLK, BMX, BTK

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to ibrutinib

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TRMT12	CTRPv2	pan-cancer	AAC	0.15	0.0005
mRNA	MIDN	CTRPv2	pan-cancer	AAC	0.14	0.0005
mRNA	IMPAD1	CTRPv2	pan-cancer	AAC	-0.15	0.0005
mRNA	TFE3	CTRPv2	pan-cancer	AAC	-0.16	0.0005
mRNA	HSH2D	CTRPv2	pan-cancer	AAC	0.17	0.0005
mRNA	TNKS1BP1	CTRPv2	pan-cancer	AAC	0.18	0.0005
mRNA	LTB	CTRPv2	pan-cancer	AAC	0.15	0.0005
mRNA	PI15	CTRPv2	pan-cancer	AAC	0.14	0.0005
mRNA	TLR1	CTRPv2	pan-cancer	AAC	0.16	0.0005
mRNA	STAG3	CTRPv2	pan-cancer	AAC	0.14	0.0005

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