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ibrutinib

ibrutinib

Synonyms

Sources	Names Used
CTRPv2	ibrutinib
PharmacoGx	ibrutinib

External IDs

Database	Identifier
Smiles:	Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Pubchem:	24821094

Annotated Targets

BLK, BMX, BTK

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to ibrutinib

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	POU2F2	CTRPv2	pan-cancer	AAC	0.19	3e-05
mRNA	DTX4	CTRPv2	pan-cancer	AAC	0.19	3e-05
mRNA	PLEKHA2	CTRPv2	pan-cancer	AAC	0.19	3e-05
mRNA	PIK3AP1	CTRPv2	pan-cancer	AAC	0.21	3e-05
mRNA	PROB1	CTRPv2	pan-cancer	AAC	0.2	3e-05
mRNA	TLR10	CTRPv2	pan-cancer	AAC	0.18	3e-05
mRNA	CD19	CTRPv2	pan-cancer	AAC	0.19	3e-05
mRNA	ENDOU	CTRPv2	pan-cancer	AAC	0.17	4e-05
mRNA	PSMD3	CTRPv2	pan-cancer	AAC	0.17	4e-05
mRNA	ACSL4	CTRPv2	pan-cancer	AAC	-0.17	4e-05

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