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OSI-027

OSI-027

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	OSI-027
PharmacoGx	OSI-027

External IDs

Database	Identifier
Smiles:	COc1cccc2cc([nH]c12)-c1nc([C@@H]2CC[C@@H](CC2)C(O)=O)n2ncnc(N)c12
Pubchem:	44224160

Annotated Targets

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-027

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	RBM10	GDSC1000	pan-cancer	AAC	0.17	3e-07
mRNA	AHR	GDSC1000	pan-cancer	AAC	-0.17	3e-07
mRNA	ANKRD46	GDSC1000	pan-cancer	AAC	0.17	3e-07
mRNA	HNRNPH3	GDSC1000	pan-cancer	AAC	0.17	3e-07
mRNA	ZNF43	GDSC1000	pan-cancer	AAC	0.17	3e-07
mRNA	JARID2	GDSC1000	pan-cancer	AAC	0.18	3e-07
mRNA	S100A11	GDSC1000	pan-cancer	AAC	-0.18	3e-07
mRNA	S100A10	GDSC1000	pan-cancer	AAC	-0.19	3e-07
mRNA	SDC4	GDSC1000	pan-cancer	AAC	-0.23	3e-07
mRNA	ZNF124	GDSC1000	pan-cancer	AAC	0.18	3e-07

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