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OSI-027

OSI-027

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	OSI-027
PharmacoGx	OSI-027

External IDs

Database	Identifier
Smiles:	COc1cccc2cc([nH]c12)-c1nc([C@@H]2CC[C@@H](CC2)C(O)=O)n2ncnc(N)c12
Pubchem:	44224160

Annotated Targets

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-027

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ASPH	GDSC1000	pan-cancer	AAC	-0.21	6e-08
mRNA	FZD3	GDSC1000	pan-cancer	AAC	0.17	6e-08
mRNA	SGTA	GDSC1000	pan-cancer	AAC	0.17	6e-08
mRNA	SLC7A3	GDSC1000	pan-cancer	AAC	0.17	6e-08
mRNA	AHNAK	GDSC1000	pan-cancer	AAC	-0.2	7e-08
mRNA	SH3D19	GDSC1000	pan-cancer	AAC	-0.22	8e-08
mRNA	SCAF4	GDSC1000	pan-cancer	AAC	0.18	8e-08
mRNA	ARID2	GDSC1000	pan-cancer	AAC	0.18	9e-08
mRNA	ZNF253	GDSC1000	pan-cancer	AAC	0.18	9e-08
mRNA	ZNF627	GDSC1000	pan-cancer	AAC	0.17	1e-07

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