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OSI-027

OSI-027

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	OSI-027
PharmacoGx	OSI-027

External IDs

Database	Identifier
Smiles:	COc1cccc2cc([nH]c12)-c1nc([C@@H]2CC[C@@H](CC2)C(O)=O)n2ncnc(N)c12
Pubchem:	44224160

Annotated Targets

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-027

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CRMP1	GDSC1000	pan-cancer	AAC	0.15	2e-05
mRNA	PHKA2	GDSC1000	pan-cancer	AAC	0.13	2e-05
mRNA	CCDC171	GDSC1000	pan-cancer	AAC	0.15	2e-05
mRNA	ZNF554	GDSC1000	pan-cancer	AAC	0.13	2e-05
mRNA	RC3H2	GDSC1000	pan-cancer	AAC	0.13	2e-05
mRNA	KIFC3	GDSC1000	pan-cancer	AAC	-0.16	2e-05
mRNA	NXF1	GDSC1000	pan-cancer	AAC	0.14	3e-05
mRNA	FAM69B	GDSC1000	pan-cancer	AAC	0.14	3e-05
mRNA	ANKRD26	GDSC1000	pan-cancer	AAC	0.13	3e-05
mRNA	HPCAL1	GDSC1000	pan-cancer	AAC	-0.14	3e-05

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