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OSI-027

OSI-027

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	OSI-027
PharmacoGx	OSI-027

External IDs

Database	Identifier
Smiles:	COc1cccc2cc([nH]c12)-c1nc([C@@H]2CC[C@@H](CC2)C(O)=O)n2ncnc(N)c12
Pubchem:	44224160

Annotated Targets

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-027

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	PLEC	GDSC1000	pan-cancer	AAC	-0.16	5e-06
mRNA	KHDRBS1	GDSC1000	pan-cancer	AAC	0.15	6e-06
mRNA	INTS6L	GDSC1000	pan-cancer	AAC	0.17	6e-06
mRNA	NUMA1	GDSC1000	pan-cancer	AAC	0.14	6e-06
mRNA	C2CD4C	GDSC1000	pan-cancer	AAC	0.14	6e-06
mRNA	MYO1C	GDSC1000	pan-cancer	AAC	-0.18	6e-06
mRNA	ITGB5	GDSC1000	pan-cancer	AAC	-0.18	6e-06
mRNA	TCF12	GDSC1000	pan-cancer	AAC	0.15	6e-06
mRNA	MGAT4B	GDSC1000	pan-cancer	AAC	-0.17	6e-06
mRNA	CERKL	GDSC1000	pan-cancer	AAC	0.14	6e-06

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