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WP1130
WP1130
Synonyms
Sources
Names Used
CTRPv2
WP1130
PharmacoGx
WP1130
External IDs
Database
Identifier
Pubchem:
11222830
Annotated Targets
JAK2
,
UCHL5
,
USP14
,
USP9X
,
USP5
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with WP1130
(per dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
815
Download SVG
Number of tissues tested with WP1130
(per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
WP1130: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
0.60
SW948
SW948
ML-1
ML-1
HCC-1588
HCC-1588
GA-10
GA-10
KMS-26
KMS-26
TTTHYROID
TTTHYROID
Pfeiffer
Pfeiffer
AML-193
AML-193
CAL-12T
CAL-12T
NU-DHL-1
NU-DHL-1
NCI-H2444
NCI-H2444
OPM-2
OPM-2
KMS-21BM
KMS-21BM
NCI-H2087
NCI-H2087
EoL-1-cell
EoL-1-cell
KNS-60
KNS-60
NCI-H211
NCI-H211
KMS-34
KMS-34
697
697
SUP-M2
SUP-M2
DEL
DEL
SK-N-BE(2)
SK-N-BE(2)
SUP-T11
SUP-T11
KMS-12-BM
KMS-12-BM
HEC-265
HEC-265
ST486
ST486
UO31
UO31
OC-314
OC-314
KASUMI-2
KASUMI-2
RS4;11
RS4;11
CAMA-1
CAMA-1
Hep 3B2.1-7
Hep 3B2.1-7
NCI-H2122
NCI-H2122
NUGC-3
NUGC-3
NCI-H1792
NCI-H1792
MDA-MB-435
MDA-MB-435
SNU-201
SNU-201
LCLC-103H
LCLC-103H
HeLa
HeLa
OVCAR-8
OVCAR-8
SNB75
SNB75
SK-OV-3
SK-OV-3
COLO-800
COLO-800
Caov-3
Caov-3
QGP-1
QGP-1
KMRC-2
KMRC-2
YAPC
YAPC
SW1783
SW1783
Hep G2
Hep G2
U-CH1
U-CH1
NCI-H2023
NCI-H2023
KARPAS-620
KARPAS-620
KYSE-70
KYSE-70
SNU-1066
SNU-1066
BICR 56
BICR 56
COV362
COV362
L3.3
L3.3
MKN45
MKN45
REC-1
REC-1
HSC-3
HSC-3
SW948
ML-1
HCC-1588
GA-10
KMS-26
TTTHYROID
Pfeiffer
AML-193
CAL-12T
NU-DHL-1
NCI-H2444
OPM-2
KMS-21BM
NCI-H2087
EoL-1-cell
KNS-60
NCI-H211
KMS-34
697
SUP-M2
DEL
SK-N-BE(2)
SUP-T11
KMS-12-BM
HEC-265
ST486
UO31
OC-314
KASUMI-2
RS4;11
CAMA-1
Hep 3B2.1-7
NCI-H2122
NUGC-3
NCI-H1792
MDA-MB-435
SNU-201
LCLC-103H
HeLa
OVCAR-8
SNB75
SK-OV-3
COLO-800
Caov-3
QGP-1
KMRC-2
YAPC
SW1783
Hep G2
U-CH1
NCI-H2023
KARPAS-620
KYSE-70
SNU-1066
BICR 56
COV362
L3.3
MKN45
REC-1
HSC-3
SW948: 0.63
Synonyms: SW948, SW 948
ML-1: 0.48
Synonyms: ML-1, ML1
HCC-1588: 0.46
Synonyms: HCC-1588, HCC1588
GA-10: 0.46
Synonyms: GA-10, GA10
KMS-26: 0.45
Synonyms: KMS-26, KMS26
TTTHYROID: 0.44
Synonyms: TTTHYROID
Pfeiffer: 0.42
Synonyms: Pfeiffer, PFEIFFER
AML-193: 0.42
Synonyms: AML-193, AML193
CAL-12T: 0.42
Synonyms: CAL-12T, CAL12T
NU-DHL-1: 0.42
Synonyms: NU-DHL-1, NUDHL1
NCI-H2444: 0.41
Synonyms: NCI-H2444, NCIH2444
OPM-2: 0.40
Synonyms: OPM-2, OPM2
KMS-21BM: 0.40
Synonyms: KMS-21BM, KMS21BM
NCI-H2087: 0.39
Synonyms: NCI-H2087, NCIH2087
EoL-1-cell: 0.38
Synonyms: EoL-1-cell, EOL-1, EOL1
KNS-60: 0.38
Synonyms: KNS-60, KNS60
NCI-H211: 0.37
Synonyms: NCI-H211, NCIH211
KMS-34: 0.37
Synonyms: KMS-34, KMS34
697: 0.37
Synonyms: 697
SUP-M2: 0.37
Synonyms: SUP-M2, SUPM2
DEL: 0.37
Synonyms: DEL
SK-N-BE(2): 0.37
Synonyms: SK-N-BE(2), SK-N-BE_2_, SKNBE2
SUP-T11: 0.36
Synonyms: SUP-T11, SUPT11
KMS-12-BM: 0.36
Synonyms: KMS-12-BM, KMS12BM
HEC-265: 0.36
Synonyms: HEC-265, HEC265
ST486: 0.36
Synonyms: ST486
UO31: 0.36
Synonyms: UO31, UO-31, U031
OC-314: 0.36
Synonyms: OC-314, OC 314, OC_314, OC314
KASUMI-2: 0.36
Synonyms: KASUMI-2, KASUMI2
RS4;11: 0.36
Synonyms: RS4;11, RS4_11, RS4-11, RS411
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
CAMA-1: 0.11
Synonyms: CAMA-1, CAMA1, cama1
Hep 3B2.1-7: 0.11
Synonyms: Hep 3B2.1-7, Hep_3B2.1-7, Hep3B2-1-7, Hep 3B2_1-7, Hep_3B2_1-7, HEP3B217
NCI-H2122: 0.11
Synonyms: NCI-H2122, NCIH2122
NUGC-3: 0.11
Synonyms: NUGC-3, NUGC3
NCI-H1792: 0.11
Synonyms: NCI-H1792, NCIH1792
MDA-MB-435: 0.11
Synonyms: MDA-MB-435, MDA-MB-435S, MDAMB435S
SNU-201: 0.11
Synonyms: SNU-201, SNU201
LCLC-103H: 0.11
Synonyms: LCLC-103H, LCLC103H
HeLa: 0.10
Synonyms: HeLa, HELA
OVCAR-8: 0.10
Synonyms: OVCAR-8, OVCAR8
SNB75: 0.10
Synonyms: SNB75
SK-OV-3: 0.10
Synonyms: SK-OV-3, SKOV3
COLO-800: 0.10
Synonyms: COLO-800, COLO 800, COLO800
Caov-3: 0.09
Synonyms: Caov-3, CAOV3
QGP-1: 0.09
Synonyms: QGP-1, QGP1
KMRC-2: 0.09
Synonyms: KMRC-2, KMRC2
YAPC: 0.09
Synonyms: YAPC
SW1783: 0.09
Synonyms: SW1783, SW 1783, SW_1783
Hep G2: 0.09
Synonyms: Hep G2, Hep_G2, HEPG2
U-CH1: 0.09
Synonyms: U-CH1
NCI-H2023: 0.08
Synonyms: NCI-H2023, NCIH2023
KARPAS-620: 0.08
Synonyms: KARPAS-620, KARPAS620
KYSE-70: 0.08
Synonyms: KYSE-70, KYSE70
SNU-1066: 0.08
Synonyms: SNU-1066, SNU1066
BICR 56: 0.07
Synonyms: BICR 56, BICR_56, BICR56
COV362: 0.06
Synonyms: COV362
L3.3: 0.06
Synonyms: L3.3, L33
MKN45: 0.05
Synonyms: MKN45, MKN-45
REC-1: 0.04
Synonyms: REC-1, REC1
HSC-3: 0.03
Synonyms: HSC-3, HSC3
Download SVG
0.00
5.00
10.00
15.00
20.00
25.00
BEN
BEN
CFPAC-1
CFPAC-1
P3HR-1
P3HR-1
HCT-116
HCT-116
L3.3
L3.3
Hs 936.T
Hs 936.T
SK-MEL-2
SK-MEL-2
REC-1
REC-1
NCI-H2126
NCI-H2126
BICR 56
BICR 56
ZR-75-1
ZR-75-1
NUGC-3
NUGC-3
COV362
COV362
KMRC-2
KMRC-2
SW1783
SW1783
KARPAS-620
KARPAS-620
LC-1/sq-SF
LC-1/sq-SF
JHH-6
JHH-6
SNB75
SNB75
CAL-120
CAL-120
JHOS-2
JHOS-2
Toledo
Toledo
NCI-H1792
NCI-H1792
MPP-89
MPP-89
SNU-201
SNU-201
NCI-H2122
NCI-H2122
NMC-G1
NMC-G1
NCI-H1651
NCI-H1651
NCI-H1373
NCI-H1373
DBTRG-05MG
DBTRG-05MG
HuT 78
HuT 78
NCI-H1666
NCI-H1666
ST486
ST486
KASUMI-2
KASUMI-2
MONO-MAC-1
MONO-MAC-1
RS4;11
RS4;11
UO31
UO31
OC-314
OC-314
NCI-H1581
NCI-H1581
DEL
DEL
KMS-12-BM
KMS-12-BM
TALL-1
TALL-1
SUP-M2
SUP-M2
NCI-H211
NCI-H211
KMS-34
KMS-34
EoL-1-cell
EoL-1-cell
697
697
SUP-T11
SUP-T11
KNS-60
KNS-60
NCI-H2444
NCI-H2444
OPM-2
OPM-2
KMS-21BM
KMS-21BM
TTTHYROID
TTTHYROID
NCI-H2087
NCI-H2087
NU-DHL-1
NU-DHL-1
Pfeiffer
Pfeiffer
AML-193
AML-193
HCC-1588
HCC-1588
ML-1
ML-1
GA-10
GA-10
BEN
CFPAC-1
P3HR-1
HCT-116
L3.3
Hs 936.T
SK-MEL-2
REC-1
NCI-H2126
BICR 56
ZR-75-1
NUGC-3
COV362
KMRC-2
SW1783
KARPAS-620
LC-1/sq-SF
JHH-6
SNB75
CAL-120
JHOS-2
Toledo
NCI-H1792
MPP-89
SNU-201
NCI-H2122
NMC-G1
NCI-H1651
NCI-H1373
DBTRG-05MG
HuT 78
NCI-H1666
ST486
KASUMI-2
MONO-MAC-1
RS4;11
UO31
OC-314
NCI-H1581
DEL
KMS-12-BM
TALL-1
SUP-M2
NCI-H211
KMS-34
EoL-1-cell
697
SUP-T11
KNS-60
NCI-H2444
OPM-2
KMS-21BM
TTTHYROID
NCI-H2087
NU-DHL-1
Pfeiffer
AML-193
HCC-1588
ML-1
GA-10
BEN: 28.43 (log10 µM)
Synonyms: BEN
CFPAC-1: 2.74 (log10 µM)
Synonyms: CFPAC-1, CFPAC1
P3HR-1: 2.54 (log10 µM)
Synonyms: P3HR-1, P3HR1
HCT-116: 2.52 (log10 µM)
Synonyms: HCT-116, HCT 116, HCT_116, HCT116
L3.3: 2.37 (log10 µM)
Synonyms: L3.3, L33
Hs 936.T: 1.96 (log10 µM)
Synonyms: Hs 936.T, Hs_936.T, HS936T
SK-MEL-2: 1.82 (log10 µM)
Synonyms: SK-MEL-2, SKMEL2
REC-1: 1.69 (log10 µM)
Synonyms: REC-1, REC1
NCI-H2126: 1.65 (log10 µM)
Synonyms: NCI-H2126, NCIH2126
BICR 56: 1.61 (log10 µM)
Synonyms: BICR 56, BICR_56, BICR56
ZR-75-1: 1.60 (log10 µM)
Synonyms: ZR-75-1, ZR751, zr751
NUGC-3: 1.60 (log10 µM)
Synonyms: NUGC-3, NUGC3
COV362: 1.56 (log10 µM)
Synonyms: COV362
KMRC-2: 1.56 (log10 µM)
Synonyms: KMRC-2, KMRC2
SW1783: 1.52 (log10 µM)
Synonyms: SW1783, SW 1783, SW_1783
KARPAS-620: 1.52 (log10 µM)
Synonyms: KARPAS-620, KARPAS620
LC-1/sq-SF: 1.44 (log10 µM)
Synonyms: LC-1/sq-SF, LC1SQSF
JHH-6: 1.42 (log10 µM)
Synonyms: JHH-6, JHH6
SNB75: 1.38 (log10 µM)
Synonyms: SNB75
CAL-120: 1.37 (log10 µM)
Synonyms: CAL-120, CAL120, cal120
JHOS-2: 1.37 (log10 µM)
Synonyms: JHOS-2, JHOS2
Toledo: 1.35 (log10 µM)
Synonyms: Toledo, TOLEDO
NCI-H1792: 1.35 (log10 µM)
Synonyms: NCI-H1792, NCIH1792
MPP-89: 1.34 (log10 µM)
Synonyms: MPP-89, MPP 89, MPP_89, MPP89
SNU-201: 1.34 (log10 µM)
Synonyms: SNU-201, SNU201
NCI-H2122: 1.34 (log10 µM)
Synonyms: NCI-H2122, NCIH2122
NMC-G1: 1.32 (log10 µM)
Synonyms: NMC-G1, NMCG1
NCI-H1651: 1.29 (log10 µM)
Synonyms: NCI-H1651, NCIH1651
NCI-H1373: 1.28 (log10 µM)
Synonyms: NCI-H1373, NCIH1373
DBTRG-05MG: 1.27 (log10 µM)
Synonyms: DBTRG-05MG, DBTRG05MG
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
HuT 78: 0.19 (log10 µM)
Synonyms: HuT 78, HuT_78, HUT78
NCI-H1666: 0.18 (log10 µM)
Synonyms: NCI-H1666, NCIH1666
ST486: 0.18 (log10 µM)
Synonyms: ST486
KASUMI-2: 0.18 (log10 µM)
Synonyms: KASUMI-2, KASUMI2
MONO-MAC-1: 0.18 (log10 µM)
Synonyms: MONO-MAC-1, MONOMAC1
RS4;11: 0.18 (log10 µM)
Synonyms: RS4;11, RS4_11, RS4-11, RS411
UO31: 0.18 (log10 µM)
Synonyms: UO31, UO-31, U031
OC-314: 0.17 (log10 µM)
Synonyms: OC-314, OC 314, OC_314, OC314
NCI-H1581: 0.16 (log10 µM)
Synonyms: NCI-H1581, NCIH1581
DEL: 0.16 (log10 µM)
Synonyms: DEL
KMS-12-BM: 0.15 (log10 µM)
Synonyms: KMS-12-BM, KMS12BM
TALL-1: 0.14 (log10 µM)
Synonyms: TALL-1, TALL1
SUP-M2: 0.13 (log10 µM)
Synonyms: SUP-M2, SUPM2
NCI-H211: 0.12 (log10 µM)
Synonyms: NCI-H211, NCIH211
KMS-34: 0.11 (log10 µM)
Synonyms: KMS-34, KMS34
EoL-1-cell: 0.11 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
697: 0.11 (log10 µM)
Synonyms: 697
SUP-T11: 0.10 (log10 µM)
Synonyms: SUP-T11, SUPT11
KNS-60: 0.08 (log10 µM)
Synonyms: KNS-60, KNS60
NCI-H2444: 0.05 (log10 µM)
Synonyms: NCI-H2444, NCIH2444
OPM-2: 0.01 (log10 µM)
Synonyms: OPM-2, OPM2
KMS-21BM: 0.01 (log10 µM)
Synonyms: KMS-21BM, KMS21BM
TTTHYROID: -0.00 (log10 µM)
Synonyms: TTTHYROID
NCI-H2087: -0.03 (log10 µM)
Synonyms: NCI-H2087, NCIH2087
NU-DHL-1: -0.06 (log10 µM)
Synonyms: NU-DHL-1, NUDHL1
Pfeiffer: -0.10 (log10 µM)
Synonyms: Pfeiffer, PFEIFFER
AML-193: -0.13 (log10 µM)
Synonyms: AML-193, AML193
HCC-1588: -0.16 (log10 µM)
Synonyms: HCC-1588, HCC1588
ML-1: -0.22 (log10 µM)
Synonyms: ML-1, ML1
GA-10: -0.26 (log10 µM)
Synonyms: GA-10, GA10
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
WP1130: AAC
AAC
Tissues
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
0.60
cervix
cervix
pleura
pleura
kidney
kidney
salivary_gland
salivary_gland
skin
skin
breast
breast
central_nervous_system
central_nervous_system
biliary_tract
biliary_tract
pancreas
pancreas
oesophagus
oesophagus
prostate
prostate
stomach
stomach
upper_aerodigestive_tract
upper_aerodigestive_tract
thyroid
thyroid
ovary
ovary
urinary_tract
urinary_tract
liver
liver
large_intestine
large_intestine
endometrium
endometrium
unknown
unknown
lung
lung
bone
bone
autonomic_ganglia
autonomic_ganglia
soft_tissue
soft_tissue
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
-0.20
0.00
0.20
0.40
0.60
0.80
1.00
1.20
cervix
cervix
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
soft_tissue
soft_tissue
bone
bone
unknown
unknown
lung
lung
autonomic_ganglia
autonomic_ganglia
ovary
ovary
large_intestine
large_intestine
liver
liver
endometrium
endometrium
urinary_tract
urinary_tract
thyroid
thyroid
stomach
stomach
breast
breast
prostate
prostate
upper_aerodigestive_tract
upper_aerodigestive_tract
oesophagus
oesophagus
kidney
kidney
pancreas
pancreas
biliary_tract
biliary_tract
salivary_gland
salivary_gland
central_nervous_system
central_nervous_system
skin
skin
pleura
pleura
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to WP1130
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
SPTBN4
CTRPv2
pan-cancer
AAC
0.13
0.0002
mRNA
SCRT2
CTRPv2
pan-cancer
AAC
0.15
0.0002
mRNA
COX4I2
CTRPv2
pan-cancer
AAC
-0.13
0.0002
mRNA
NTN3
CTRPv2
pan-cancer
AAC
0.13
0.0002
mRNA
KIAA1147
CTRPv2
pan-cancer
AAC
0.13
0.0002
mRNA
AC024361.1
CTRPv2
pan-cancer
AAC
0.14
0.0002
mRNA
GOLGA6L9
CTRPv2
pan-cancer
AAC
0.13
0.0003
mRNA
KCNH3
CTRPv2
pan-cancer
AAC
0.13
0.0003
mRNA
FMC1
CTRPv2
pan-cancer
AAC
0.13
0.0003
mRNA
IGSF9
CTRPv2
pan-cancer
AAC
0.14
0.0003
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