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Compounds
/
clofarabine
clofarabine
Synonyms
Sources
Names Used
CTRPv2
clofarabine
PharmacoGx
clofarabine
External IDs
Database
Identifier
Smiles:
Nc1nc(Cl)nc2n(cnc12)C3OC(CO)C(O)C3F
Inchikey:
WDDPHFBMKLOVOX-UHFFFAOYSA-N
Pubchem:
119182
Annotated Targets
POLA1
,
POLD1
,
POLE
,
RRM1
,
RRM2
,
RRM2B
FDA Approval Status
Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with clofarabine
(per dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
854
Download SVG
Number of tissues tested with clofarabine
(per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
clofarabine: AAC
AAC
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
RS4;11
RS4;11
BV-173
BV-173
REH
REH
697
697
OCI-AML2
OCI-AML2
MHH-CALL-4
MHH-CALL-4
JM1
JM1
RCH-ACV
RCH-ACV
MOLT-16
MOLT-16
KASUMI-2
KASUMI-2
PL-21
PL-21
U-937
U-937
JURL-MK1
JURL-MK1
DOHH-2
DOHH-2
NALM-6
NALM-6
SUP-T1
SUP-T1
SU-DHL-8
SU-DHL-8
CML-T1
CML-T1
ALL-SIL
ALL-SIL
EoL-1-cell
EoL-1-cell
HEL 92.1.7
HEL 92.1.7
SUP-B15
SUP-B15
NOMO-1
NOMO-1
MONO-MAC-1
MONO-MAC-1
WSU-DLCL2
WSU-DLCL2
P12-ICHIKAWA
P12-ICHIKAWA
MC116
MC116
EM-2
EM-2
Mino
Mino
MOLM-6
MOLM-6
JHH-2
JHH-2
SNU-1077
SNU-1077
Hs-578-T
Hs-578-T
OCI-AML5
OCI-AML5
HCC2935
HCC2935
FU-OV-1
FU-OV-1
ZR-75-30
ZR-75-30
SNU-201
SNU-201
HCC1428
HCC1428
HT-29
HT-29
CAL-120
CAL-120
MKN45
MKN45
HCC1937
HCC1937
Hs 822.T
Hs 822.T
HCC1419
HCC1419
KPL-1
KPL-1
SNU-1105
SNU-1105
RERF-LC-Ad1
RERF-LC-Ad1
MDA-MB-415
MDA-MB-415
NH-6
NH-6
KP-N-YN
KP-N-YN
JHOM-1
JHOM-1
OUMS-23
OUMS-23
REC-1
REC-1
A253
A253
MES-SA
MES-SA
JHH-6
JHH-6
PA-TU-8988T
PA-TU-8988T
MDA-MB-361
MDA-MB-361
BICR 16
BICR 16
RS4;11
BV-173
REH
697
OCI-AML2
MHH-CALL-4
JM1
RCH-ACV
MOLT-16
KASUMI-2
PL-21
U-937
JURL-MK1
DOHH-2
NALM-6
SUP-T1
SU-DHL-8
CML-T1
ALL-SIL
EoL-1-cell
HEL 92.1.7
SUP-B15
NOMO-1
MONO-MAC-1
WSU-DLCL2
P12-ICHIKAWA
MC116
EM-2
Mino
MOLM-6
JHH-2
SNU-1077
Hs-578-T
OCI-AML5
HCC2935
FU-OV-1
ZR-75-30
SNU-201
HCC1428
HT-29
CAL-120
MKN45
HCC1937
Hs 822.T
HCC1419
KPL-1
SNU-1105
RERF-LC-Ad1
MDA-MB-415
NH-6
KP-N-YN
JHOM-1
OUMS-23
REC-1
A253
MES-SA
JHH-6
PA-TU-8988T
MDA-MB-361
BICR 16
RS4;11: 0.95
Synonyms: RS4;11, RS4_11, RS4-11, RS411
BV-173: 0.94
Synonyms: BV-173, BV173
REH: 0.94
Synonyms: REH, Reh
697: 0.90
Synonyms: 697
OCI-AML2: 0.89
Synonyms: OCI-AML2, OCIAML2
MHH-CALL-4: 0.88
Synonyms: MHH-CALL-4, MHHCALL4
JM1: 0.88
Synonyms: JM1
RCH-ACV: 0.86
Synonyms: RCH-ACV, RCHACV
MOLT-16: 0.85
Synonyms: MOLT-16, MOLT16
KASUMI-2: 0.85
Synonyms: KASUMI-2, KASUMI2
PL-21: 0.85
Synonyms: PL-21, PL21
U-937: 0.84
Synonyms: U-937, U937
JURL-MK1: 0.84
Synonyms: JURL-MK1, JURLMK1
DOHH-2: 0.84
Synonyms: DOHH-2, DOHH2
NALM-6: 0.83
Synonyms: NALM-6, NALM6
SUP-T1: 0.83
Synonyms: SUP-T1, SUPT1
SU-DHL-8: 0.82
Synonyms: SU-DHL-8, SUDHL8
CML-T1: 0.82
Synonyms: CML-T1, CMLT1
ALL-SIL: 0.81
Synonyms: ALL-SIL, ALLSIL
EoL-1-cell: 0.81
Synonyms: EoL-1-cell, EOL-1, EOL1
HEL 92.1.7: 0.81
Synonyms: HEL 92.1.7, HEL_92.1.7, HEL9217
SUP-B15: 0.81
Synonyms: SUP-B15, SUPB15
NOMO-1: 0.81
Synonyms: NOMO-1, NOMO1
MONO-MAC-1: 0.80
Synonyms: MONO-MAC-1, MONOMAC1
WSU-DLCL2: 0.80
Synonyms: WSU-DLCL2, WSUDLCL2
P12-ICHIKAWA: 0.79
Synonyms: P12-ICHIKAWA, P12ICHIKAWA
MC116: 0.79
Synonyms: MC116
EM-2: 0.79
Synonyms: EM-2, EM2
Mino: 0.79
Synonyms: Mino, MINO
MOLM-6: 0.79
Synonyms: MOLM-6, MOLM6
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
JHH-2: 0.02
Synonyms: JHH-2, JHH2
SNU-1077: 0.02
Synonyms: SNU-1077, SNU1077
Hs-578-T: 0.02
Synonyms: Hs-578-T, Hs 578T, Hs_578T, HS578T, hs578t
OCI-AML5: 0.02
Synonyms: OCI-AML5, OCIAML5
HCC2935: 0.01
Synonyms: HCC2935
FU-OV-1: 0.01
Synonyms: FU-OV-1, FUOV1
ZR-75-30: 0.01
Synonyms: ZR-75-30, ZR7530, zr7530
SNU-201: 0.01
Synonyms: SNU-201, SNU201
HCC1428: 0.01
Synonyms: HCC1428, hcc1428
HT-29: 0.01
Synonyms: HT-29, HT29
CAL-120: 0.01
Synonyms: CAL-120, CAL120, cal120
MKN45: 0.01
Synonyms: MKN45, MKN-45
HCC1937: 0.01
Synonyms: HCC1937, hcc1937
Hs 822.T: 0.01
Synonyms: Hs 822.T, Hs_822.T, HS822T
HCC1419: 0.01
Synonyms: HCC1419, hcc1419
KPL-1: 0.01
Synonyms: KPL-1, KPL1, kpl1
SNU-1105: 0.01
Synonyms: SNU-1105, SNU1105
RERF-LC-Ad1: 0.00
Synonyms: RERF-LC-Ad1, RERFLCAD1
MDA-MB-415: 0.00
Synonyms: MDA-MB-415, MDAMB415, mdamb415
NH-6: 0.00
Synonyms: NH-6, NH6
KP-N-YN: 0.00
Synonyms: KP-N-YN, KPNYN
JHOM-1: 0.00
Synonyms: JHOM-1, JHOM1
OUMS-23: 0.00
Synonyms: OUMS-23, OUMS23
REC-1: 0.00
Synonyms: REC-1, REC1
A253: 0.00
Synonyms: A253, A-253
MES-SA: 0.00
Synonyms: MES-SA, MESSA
JHH-6: 0.00
Synonyms: JHH-6, JHH6
PA-TU-8988T: 0.00
Synonyms: PA-TU-8988T, PATU8988T
MDA-MB-361: 0.00
Synonyms: MDA-MB-361, MDAMB361, mdamb361
BICR 16: 0.00
Synonyms: BICR 16, BICR_16, BICR16
Download SVG
-4.00
-2.00
0.00
2.00
4.00
6.00
8.00
10.00
12.00
BT320
BT320
CAMA-1
CAMA-1
NCI-H2122
NCI-H2122
HT-1376
HT-1376
COR-L88
COR-L88
NCI-H2126
NCI-H2126
HCC4006
HCC4006
CAL-120
CAL-120
BL-41
BL-41
VMRC-RCW
VMRC-RCW
SNU-1077
SNU-1077
SNU-119
SNU-119
RKN
RKN
HCC2935
HCC2935
HCC2218
HCC2218
Hep 3B2.1-7
Hep 3B2.1-7
JL-1
JL-1
PK-45H
PK-45H
MHH-NB-11
MHH-NB-11
JHH-2
JHH-2
KG-1-C
KG-1-C
NCI-H889
NCI-H889
NCI-H1755
NCI-H1755
VMRC-LCD
VMRC-LCD
CCF-STTG1
CCF-STTG1
Sq-1
Sq-1
MDA-MB-415
MDA-MB-415
KM12
KM12
NCI-H2141
NCI-H2141
OCI-AML5
OCI-AML5
DOHH-2
DOHH-2
DB
DB
NOMO-1
NOMO-1
SUP-B15
SUP-B15
NALM-6
NALM-6
GA-10
GA-10
MV-4-11
MV-4-11
JURL-MK1
JURL-MK1
KASUMI-2
KASUMI-2
Raji
Raji
TALL-1
TALL-1
JM1
JM1
RCH-ACV
RCH-ACV
REH
REH
MHH-CALL-4
MHH-CALL-4
GDM-1
GDM-1
CL-34
CL-34
697
697
U-937
U-937
MC116
MC116
SUP-T11
SUP-T11
PL-21
PL-21
MOLT-16
MOLT-16
SU-DHL-8
SU-DHL-8
OCI-AML2
OCI-AML2
HPB-ALL
HPB-ALL
MONO-MAC-1
MONO-MAC-1
SUP-T1
SUP-T1
MOLM-6
MOLM-6
RS4;11
RS4;11
BT320
CAMA-1
NCI-H2122
HT-1376
COR-L88
NCI-H2126
HCC4006
CAL-120
BL-41
VMRC-RCW
SNU-1077
SNU-119
RKN
HCC2935
HCC2218
Hep 3B2.1-7
JL-1
PK-45H
MHH-NB-11
JHH-2
KG-1-C
NCI-H889
NCI-H1755
VMRC-LCD
CCF-STTG1
Sq-1
MDA-MB-415
KM12
NCI-H2141
OCI-AML5
DOHH-2
DB
NOMO-1
SUP-B15
NALM-6
GA-10
MV-4-11
JURL-MK1
KASUMI-2
Raji
TALL-1
JM1
RCH-ACV
REH
MHH-CALL-4
GDM-1
CL-34
697
U-937
MC116
SUP-T11
PL-21
MOLT-16
SU-DHL-8
OCI-AML2
HPB-ALL
MONO-MAC-1
SUP-T1
MOLM-6
RS4;11
BT320: 12.21 (log10 µM)
Synonyms: BT320
CAMA-1: 7.71 (log10 µM)
Synonyms: CAMA-1, CAMA1, cama1
NCI-H2122: 7.17 (log10 µM)
Synonyms: NCI-H2122, NCIH2122
HT-1376: 6.34 (log10 µM)
Synonyms: HT-1376, HT1376
COR-L88: 6.00 (log10 µM)
Synonyms: COR-L88, CORL88
NCI-H2126: 5.19 (log10 µM)
Synonyms: NCI-H2126, NCIH2126
HCC4006: 4.65 (log10 µM)
Synonyms: HCC4006
CAL-120: 3.98 (log10 µM)
Synonyms: CAL-120, CAL120, cal120
BL-41: 3.74 (log10 µM)
Synonyms: BL-41, BL41
VMRC-RCW: 3.71 (log10 µM)
Synonyms: VMRC-RCW, VMRCRCW
SNU-1077: 3.37 (log10 µM)
Synonyms: SNU-1077, SNU1077
SNU-119: 3.37 (log10 µM)
Synonyms: SNU-119, SNU119
RKN: 3.28 (log10 µM)
Synonyms: RKN
HCC2935: 3.20 (log10 µM)
Synonyms: HCC2935
HCC2218: 3.09 (log10 µM)
Synonyms: HCC2218, hcc2218
Hep 3B2.1-7: 3.07 (log10 µM)
Synonyms: Hep 3B2.1-7, Hep_3B2.1-7, Hep3B2-1-7, Hep 3B2_1-7, Hep_3B2_1-7, HEP3B217
JL-1: 3.06 (log10 µM)
Synonyms: JL-1, JL1
PK-45H: 2.97 (log10 µM)
Synonyms: PK-45H, PK45H
MHH-NB-11: 2.71 (log10 µM)
Synonyms: MHH-NB-11, MHHNB11
JHH-2: 2.69 (log10 µM)
Synonyms: JHH-2, JHH2
KG-1-C: 2.63 (log10 µM)
Synonyms: KG-1-C, KG1C
NCI-H889: 2.55 (log10 µM)
Synonyms: NCI-H889, NCIH889
NCI-H1755: 2.49 (log10 µM)
Synonyms: NCI-H1755, NCIH1755
VMRC-LCD: 2.41 (log10 µM)
Synonyms: VMRC-LCD, VMRCLCD
CCF-STTG1: 2.35 (log10 µM)
Synonyms: CCF-STTG1, CCFSTTG1
Sq-1: 2.26 (log10 µM)
Synonyms: Sq-1, SQ1
MDA-MB-415: 2.19 (log10 µM)
Synonyms: MDA-MB-415, MDAMB415, mdamb415
KM12: 2.14 (log10 µM)
Synonyms: KM12, KM-12
NCI-H2141: 1.89 (log10 µM)
Synonyms: NCI-H2141, NCIH2141
OCI-AML5: 1.83 (log10 µM)
Synonyms: OCI-AML5, OCIAML5
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
DOHH-2: -1.99 (log10 µM)
Synonyms: DOHH-2, DOHH2
DB: -1.99 (log10 µM)
Synonyms: DB
NOMO-1: -2.00 (log10 µM)
Synonyms: NOMO-1, NOMO1
SUP-B15: -2.00 (log10 µM)
Synonyms: SUP-B15, SUPB15
NALM-6: -2.03 (log10 µM)
Synonyms: NALM-6, NALM6
GA-10: -2.04 (log10 µM)
Synonyms: GA-10, GA10
MV-4-11: -2.05 (log10 µM)
Synonyms: MV-4-11, MV411
JURL-MK1: -2.08 (log10 µM)
Synonyms: JURL-MK1, JURLMK1
KASUMI-2: -2.11 (log10 µM)
Synonyms: KASUMI-2, KASUMI2
Raji: -2.15 (log10 µM)
Synonyms: Raji, RAJI
TALL-1: -2.15 (log10 µM)
Synonyms: TALL-1, TALL1
JM1: -2.19 (log10 µM)
Synonyms: JM1
RCH-ACV: -2.20 (log10 µM)
Synonyms: RCH-ACV, RCHACV
REH: -2.22 (log10 µM)
Synonyms: REH, Reh
MHH-CALL-4: -2.26 (log10 µM)
Synonyms: MHH-CALL-4, MHHCALL4
GDM-1: -2.29 (log10 µM)
Synonyms: GDM-1, GDM1
CL-34: -2.29 (log10 µM)
Synonyms: CL-34, CL34
697: -2.35 (log10 µM)
Synonyms: 697
U-937: -2.38 (log10 µM)
Synonyms: U-937, U937
MC116: -2.41 (log10 µM)
Synonyms: MC116
SUP-T11: -2.44 (log10 µM)
Synonyms: SUP-T11, SUPT11
PL-21: -2.45 (log10 µM)
Synonyms: PL-21, PL21
MOLT-16: -2.53 (log10 µM)
Synonyms: MOLT-16, MOLT16
SU-DHL-8: -2.66 (log10 µM)
Synonyms: SU-DHL-8, SUDHL8
OCI-AML2: -2.81 (log10 µM)
Synonyms: OCI-AML2, OCIAML2
HPB-ALL: -2.87 (log10 µM)
Synonyms: HPB-ALL, HPBALL
MONO-MAC-1: -3.55 (log10 µM)
Synonyms: MONO-MAC-1, MONOMAC1
SUP-T1: -3.66 (log10 µM)
Synonyms: SUP-T1, SUPT1
MOLM-6: -4.38 (log10 µM)
Synonyms: MOLM-6, MOLM6
RS4;11: -5.34 (log10 µM)
Synonyms: RS4;11, RS4_11, RS4-11, RS411
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
clofarabine: AAC
AAC
Tissues
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
cervix
cervix
kidney
kidney
liver
liver
ovary
ovary
oesophagus
oesophagus
breast
breast
central_nervous_system
central_nervous_system
pancreas
pancreas
pleura
pleura
biliary_tract
biliary_tract
lung
lung
large_intestine
large_intestine
skin
skin
urinary_tract
urinary_tract
prostate
prostate
endometrium
endometrium
upper_aerodigestive_tract
upper_aerodigestive_tract
unknown
unknown
autonomic_ganglia
autonomic_ganglia
stomach
stomach
thyroid
thyroid
bone
bone
soft_tissue
soft_tissue
salivary_gland
salivary_gland
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
-5.00
-4.00
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
5.00
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
salivary_gland
salivary_gland
bone
bone
soft_tissue
soft_tissue
pleura
pleura
skin
skin
pancreas
pancreas
breast
breast
large_intestine
large_intestine
ovary
ovary
oesophagus
oesophagus
lung
lung
upper_aerodigestive_tract
upper_aerodigestive_tract
unknown
unknown
kidney
kidney
urinary_tract
urinary_tract
stomach
stomach
autonomic_ganglia
autonomic_ganglia
prostate
prostate
liver
liver
cervix
cervix
thyroid
thyroid
endometrium
endometrium
biliary_tract
biliary_tract
central_nervous_system
central_nervous_system
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to clofarabine
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
AUNIP
CTRPv2
pan-cancer
AAC
0.1
0.0008
mRNA
GADD45B
CTRPv2
pan-cancer
AAC
-0.098
0.0008
mRNA
TSC22D2
CTRPv2
pan-cancer
AAC
-0.1
0.0008
mRNA
LSM6
CTRPv2
pan-cancer
AAC
0.1
0.0008
mRNA
TELO2
CTRPv2
pan-cancer
AAC
0.1
0.0008
mRNA
SRSF5
CTRPv2
pan-cancer
AAC
0.1
0.0008
mRNA
AC002985.3
CTRPv2
pan-cancer
AAC
-0.099
0.0008
mRNA
PRKCDBP
CTRPv2
pan-cancer
AAC
-0.1
0.0008
mRNA
TMF1
CTRPv2
pan-cancer
AAC
-0.1
0.0008
mRNA
TRIM28
CTRPv2
pan-cancer
AAC
0.099
0.0008
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