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clofarabine

clofarabine

Synonyms

Sources	Names Used
CTRPv2	clofarabine
PharmacoGx	clofarabine

External IDs

Database	Identifier
Smiles:	Nc1nc(Cl)nc2n(cnc12)C3OC(CO)C(O)C3F
Inchikey:	WDDPHFBMKLOVOX-UHFFFAOYSA-N
Pubchem:	119182

Annotated Targets

POLA1, POLD1, POLE, RRM1, RRM2, RRM2B

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to clofarabine

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	FBXO41	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	GPX8	CTRPv2	pan-cancer	AAC	-0.14	0.0001
mRNA	ZNF184	CTRPv2	pan-cancer	AAC	0.13	0.0001
mRNA	SLC39A13	CTRPv2	pan-cancer	AAC	-0.13	0.0001
mRNA	DHFR	CTRPv2	pan-cancer	AAC	0.12	0.0001
mRNA	NISCH	CTRPv2	pan-cancer	AAC	0.12	0.0001
mRNA	RCC1	CTRPv2	pan-cancer	AAC	0.11	0.0001
mRNA	MGAT4B	CTRPv2	pan-cancer	AAC	-0.13	0.0001
mRNA	SLC10A3	CTRPv2	pan-cancer	AAC	-0.11	0.0001
mRNA	DDX46	CTRPv2	pan-cancer	AAC	0.11	0.0001

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