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Compounds
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tretinoin:navitoclax (4:1 mol/mol)
tretinoin:navitoclax (4:1 mol/mol)
Synonyms
Sources
Names Used
CTRPv2
tretinoin:navitoclax (4:1 mol/mol)
PharmacoGx
tretinoin:navitoclax (4:1 mol/mol)
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
tretinoin:navitoclax (4:1 mol/mol) (per
dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
825
Download SVG
Number of tissues tested with
tretinoin:navitoclax (4:1 mol/mol) (per
dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
tretinoin:navitoclax (4:1 mol/mol): AAC
AAC
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
OCI-AML3
OCI-AML3
EoL-1-cell
EoL-1-cell
TUHR14TKB
TUHR14TKB
SNU-886
SNU-886
MV-4-11
MV-4-11
SIG-M5
SIG-M5
K052
K052
Mino
Mino
Gp2D
Gp2D
JVM-2
JVM-2
SNU-466
SNU-466
RI-1
RI-1
NCI-H146
NCI-H146
U-CH1
U-CH1
BT239
BT239
ECC10
ECC10
MOLM-13
MOLM-13
MDA-MB-415
MDA-MB-415
SK-N-DZ
SK-N-DZ
MDA-MB-157
MDA-MB-157
HuT 78
HuT 78
NCI-H660
NCI-H660
TUHR10TKB
TUHR10TKB
NCI-H1105
NCI-H1105
NCI-H1341
NCI-H1341
RH-18
RH-18
NCI-H1975
NCI-H1975
SEM
SEM
JVM-3
JVM-3
MOLM-6
MOLM-6
MFE-319
MFE-319
GSU
GSU
HCC-1588
HCC-1588
BT422
BT422
KURAMOCHI
KURAMOCHI
YKG-1
YKG-1
DMS-114
DMS-114
A172
A172
HOS
HOS
42-MG-BA
42-MG-BA
SNU-601
SNU-601
OVK18
OVK18
639-V
639-V
DAN-G
DAN-G
HMCB
HMCB
huH-1
huH-1
CFPAC-1
CFPAC-1
A101D
A101D
CAL-12T
CAL-12T
BFTC-905
BFTC-905
CAL-62
CAL-62
ONCO-DG-1
ONCO-DG-1
BEN
BEN
HT-29
HT-29
YD-15
YD-15
SW 1271
SW 1271
BT-549
BT-549
A2058
A2058
IST-MES1
IST-MES1
PA-TU-8988T
PA-TU-8988T
OCI-AML3
EoL-1-cell
TUHR14TKB
SNU-886
MV-4-11
SIG-M5
K052
Mino
Gp2D
JVM-2
SNU-466
RI-1
NCI-H146
U-CH1
BT239
ECC10
MOLM-13
MDA-MB-415
SK-N-DZ
MDA-MB-157
HuT 78
NCI-H660
TUHR10TKB
NCI-H1105
NCI-H1341
RH-18
NCI-H1975
SEM
JVM-3
MOLM-6
MFE-319
GSU
HCC-1588
BT422
KURAMOCHI
YKG-1
DMS-114
A172
HOS
42-MG-BA
SNU-601
OVK18
639-V
DAN-G
HMCB
huH-1
CFPAC-1
A101D
CAL-12T
BFTC-905
CAL-62
ONCO-DG-1
BEN
HT-29
YD-15
SW 1271
BT-549
A2058
IST-MES1
PA-TU-8988T
OCI-AML3: 0.91
Synonyms: OCI-AML3, OCIAML3
EoL-1-cell: 0.91
Synonyms: EoL-1-cell, EOL-1, EOL1
TUHR14TKB: 0.89
Synonyms: TUHR14TKB
SNU-886: 0.87
Synonyms: SNU-886, SNU886
MV-4-11: 0.78
Synonyms: MV-4-11, MV411
SIG-M5: 0.75
Synonyms: SIG-M5, SIGM5
K052: 0.73
Synonyms: K052, KO52
Mino: 0.73
Synonyms: Mino, MINO
Gp2D: 0.71
Synonyms: Gp2D, GP2d, GP2D
JVM-2: 0.71
Synonyms: JVM-2, JVM2
SNU-466: 0.70
Synonyms: SNU-466, SNU466
RI-1: 0.69
Synonyms: RI-1, RI1
NCI-H146: 0.68
Synonyms: NCI-H146, NCIH146
U-CH1: 0.68
Synonyms: U-CH1
BT239: 0.67
Synonyms: BT239
ECC10: 0.67
Synonyms: ECC10
MOLM-13: 0.64
Synonyms: MOLM-13, MOLM13
MDA-MB-415: 0.64
Synonyms: MDA-MB-415, MDAMB415, mdamb415
SK-N-DZ: 0.63
Synonyms: SK-N-DZ, SKNDZ
MDA-MB-157: 0.62
Synonyms: MDA-MB-157, MDAMB157, mdamb157
HuT 78: 0.60
Synonyms: HuT 78, HuT_78, HUT78
NCI-H660: 0.60
Synonyms: NCI-H660, NCIH660
TUHR10TKB: 0.59
Synonyms: TUHR10TKB
NCI-H1105: 0.58
Synonyms: NCI-H1105, NCIH1105
NCI-H1341: 0.58
Synonyms: NCI-H1341, NCIH1341
RH-18: 0.57
Synonyms: RH-18, RH18
NCI-H1975: 0.57
Synonyms: NCI-H1975, NCIH1975
SEM: 0.57
Synonyms: SEM
JVM-3: 0.57
Synonyms: JVM-3, JVM3
MOLM-6: 0.57
Synonyms: MOLM-6, MOLM6
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
MFE-319: 0.00
Synonyms: MFE-319, MFE319
GSU: 0.00
Synonyms: GSU
HCC-1588: 0.00
Synonyms: HCC-1588, HCC1588
BT422: 0.00
Synonyms: BT422
KURAMOCHI: 0.00
Synonyms: KURAMOCHI
YKG-1: 0.00
Synonyms: YKG-1, YKG1
DMS-114: 0.00
Synonyms: DMS-114, DMS 114, DMS_114, DMS114
A172: 0.00
Synonyms: A172
HOS: 0.00
Synonyms: HOS
42-MG-BA: 0.00
Synonyms: 42-MG-BA, 42MGBA
SNU-601: 0.00
Synonyms: SNU-601, SNU601
OVK18: 0.00
Synonyms: OVK18, OVK-18
639-V: 0.00
Synonyms: 639-V, 639V
DAN-G: 0.00
Synonyms: DAN-G, DANG
HMCB: 0.00
Synonyms: HMCB
huH-1: 0.00
Synonyms: huH-1, HUH1
CFPAC-1: 0.00
Synonyms: CFPAC-1, CFPAC1
A101D: 0.00
Synonyms: A101D
CAL-12T: 0.00
Synonyms: CAL-12T, CAL12T
BFTC-905: 0.00
Synonyms: BFTC-905, BFTC905
CAL-62: 0.00
Synonyms: CAL-62, CAL62
ONCO-DG-1: 0.00
Synonyms: ONCO-DG-1, ONCODG1
BEN: 0.00
Synonyms: BEN
HT-29: 0.00
Synonyms: HT-29, HT29
YD-15: 0.00
Synonyms: YD-15, YD15
SW 1271: 0.00
Synonyms: SW 1271, SW_1271, SW1271
BT-549: 0.00
Synonyms: BT-549, BT549, bt549
A2058: 0.00
Synonyms: A2058
IST-MES1: 0.00
Synonyms: IST-MES1, ISTMES1
PA-TU-8988T: 0.00
Synonyms: PA-TU-8988T, PATU8988T
Download SVG
0.00
10.00
20.00
30.00
40.00
50.00
60.00
70.00
80.00
90.00
100.00
110.00
COV362
COV362
SK-MEL-2
SK-MEL-2
SH-4
SH-4
COV644
COV644
HEC-50B
HEC-50B
SHP-77
SHP-77
L-363
L-363
KMRC-20
KMRC-20
LCLC-97TM1
LCLC-97TM1
LoVo
LoVo
SK-MEL-5
SK-MEL-5
TE-14
TE-14
RKN
RKN
253J-BV
253J-BV
HCC1806
HCC1806
KMM-1
KMM-1
NCI-H1395
NCI-H1395
JURKAT
JURKAT
647-V
647-V
GMS-10
GMS-10
RT4
RT4
BT12
BT12
JHOS-2
JHOS-2
IPC-298
IPC-298
DOV13
DOV13
SCC-9
SCC-9
SR-786
SR-786
SNU-1214
SNU-1214
COLO-684
COLO-684
FU97
FU97
JVM-3
JVM-3
KASUMI-2
KASUMI-2
RH-18
RH-18
NCI-H1793
NCI-H1793
NCI-H660
NCI-H660
NU-DHL-1
NU-DHL-1
TUHR10TKB
TUHR10TKB
HH
HH
NCI-H1975
NCI-H1975
TALL-1
TALL-1
SK-N-DZ
SK-N-DZ
MOLM-13
MOLM-13
HuT 78
HuT 78
MDA-MB-415
MDA-MB-415
U-CH1
U-CH1
BT239
BT239
K052
K052
NCI-H146
NCI-H146
SNU-466
SNU-466
ECC10
ECC10
SIG-M5
SIG-M5
MDA-MB-157
MDA-MB-157
RI-1
RI-1
Mino
Mino
JVM-2
JVM-2
MV-4-11
MV-4-11
EoL-1-cell
EoL-1-cell
SNU-886
SNU-886
Gp2D
Gp2D
OCI-AML3
OCI-AML3
COV362
SK-MEL-2
SH-4
COV644
HEC-50B
SHP-77
L-363
KMRC-20
LCLC-97TM1
LoVo
SK-MEL-5
TE-14
RKN
253J-BV
HCC1806
KMM-1
NCI-H1395
JURKAT
647-V
GMS-10
RT4
BT12
JHOS-2
IPC-298
DOV13
SCC-9
SR-786
SNU-1214
COLO-684
FU97
JVM-3
KASUMI-2
RH-18
NCI-H1793
NCI-H660
NU-DHL-1
TUHR10TKB
HH
NCI-H1975
TALL-1
SK-N-DZ
MOLM-13
HuT 78
MDA-MB-415
U-CH1
BT239
K052
NCI-H146
SNU-466
ECC10
SIG-M5
MDA-MB-157
RI-1
Mino
JVM-2
MV-4-11
EoL-1-cell
SNU-886
Gp2D
OCI-AML3
COV362: 112.51 (log10 µM)
Synonyms: COV362
SK-MEL-2: 19.70 (log10 µM)
Synonyms: SK-MEL-2, SKMEL2
SH-4: 16.12 (log10 µM)
Synonyms: SH-4, SH4
COV644: 13.47 (log10 µM)
Synonyms: COV644
HEC-50B: 13.30 (log10 µM)
Synonyms: HEC-50B, HEC50B
SHP-77: 12.36 (log10 µM)
Synonyms: SHP-77, SHP77
L-363: 11.85 (log10 µM)
Synonyms: L-363, L363
KMRC-20: 11.00 (log10 µM)
Synonyms: KMRC-20, KMRC20
LCLC-97TM1: 10.83 (log10 µM)
Synonyms: LCLC-97TM1, LCLC97TM1
LoVo: 10.50 (log10 µM)
Synonyms: LoVo, LOVO
SK-MEL-5: 10.28 (log10 µM)
Synonyms: SK-MEL-5, SKMEL5
TE-14: 9.89 (log10 µM)
Synonyms: TE-14, TE14
RKN: 9.71 (log10 µM)
Synonyms: RKN
253J-BV: 9.00 (log10 µM)
Synonyms: 253J-BV, 253JBV
HCC1806: 8.12 (log10 µM)
Synonyms: HCC1806, hcc1806
KMM-1: 7.80 (log10 µM)
Synonyms: KMM-1, KMM1
NCI-H1395: 7.64 (log10 µM)
Synonyms: NCI-H1395, NCIH1395
JURKAT: 7.56 (log10 µM)
Synonyms: JURKAT, Jurkat
647-V: 7.49 (log10 µM)
Synonyms: 647-V, 647V
GMS-10: 6.71 (log10 µM)
Synonyms: GMS-10, GMS10
RT4: 6.51 (log10 µM)
Synonyms: RT4
BT12: 6.00 (log10 µM)
Synonyms: BT12
JHOS-2: 6.00 (log10 µM)
Synonyms: JHOS-2, JHOS2
IPC-298: 5.93 (log10 µM)
Synonyms: IPC-298, IPC298
DOV13: 5.87 (log10 µM)
Synonyms: DOV13
SCC-9: 5.75 (log10 µM)
Synonyms: SCC-9, SCC9
SR-786: 5.67 (log10 µM)
Synonyms: SR-786, SR786
SNU-1214: 5.56 (log10 µM)
Synonyms: SNU-1214, SNU1214
COLO-684: 5.54 (log10 µM)
Synonyms: COLO-684, COLO 684, COLO_684, COLO684
FU97: 5.43 (log10 µM)
Synonyms: FU97
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
JVM-3: -0.76 (log10 µM)
Synonyms: JVM-3, JVM3
KASUMI-2: -0.77 (log10 µM)
Synonyms: KASUMI-2, KASUMI2
RH-18: -0.79 (log10 µM)
Synonyms: RH-18, RH18
NCI-H1793: -0.80 (log10 µM)
Synonyms: NCI-H1793, NCIH1793
NCI-H660: -0.81 (log10 µM)
Synonyms: NCI-H660, NCIH660
NU-DHL-1: -0.83 (log10 µM)
Synonyms: NU-DHL-1, NUDHL1
TUHR10TKB: -0.84 (log10 µM)
Synonyms: TUHR10TKB
HH: -0.86 (log10 µM)
Synonyms: HH
NCI-H1975: -0.89 (log10 µM)
Synonyms: NCI-H1975, NCIH1975
TALL-1: -0.89 (log10 µM)
Synonyms: TALL-1, TALL1
SK-N-DZ: -0.96 (log10 µM)
Synonyms: SK-N-DZ, SKNDZ
MOLM-13: -0.97 (log10 µM)
Synonyms: MOLM-13, MOLM13
HuT 78: -0.99 (log10 µM)
Synonyms: HuT 78, HuT_78, HUT78
MDA-MB-415: -1.04 (log10 µM)
Synonyms: MDA-MB-415, MDAMB415, mdamb415
U-CH1: -1.15 (log10 µM)
Synonyms: U-CH1
BT239: -1.25 (log10 µM)
Synonyms: BT239
K052: -1.27 (log10 µM)
Synonyms: K052, KO52
NCI-H146: -1.28 (log10 µM)
Synonyms: NCI-H146, NCIH146
SNU-466: -1.29 (log10 µM)
Synonyms: SNU-466, SNU466
ECC10: -1.38 (log10 µM)
Synonyms: ECC10
SIG-M5: -1.39 (log10 µM)
Synonyms: SIG-M5, SIGM5
MDA-MB-157: -1.42 (log10 µM)
Synonyms: MDA-MB-157, MDAMB157, mdamb157
RI-1: -1.45 (log10 µM)
Synonyms: RI-1, RI1
Mino: -1.55 (log10 µM)
Synonyms: Mino, MINO
JVM-2: -1.56 (log10 µM)
Synonyms: JVM-2, JVM2
MV-4-11: -2.22 (log10 µM)
Synonyms: MV-4-11, MV411
EoL-1-cell: -3.01 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
SNU-886: -4.82 (log10 µM)
Synonyms: SNU-886, SNU886
Gp2D: -5.75 (log10 µM)
Synonyms: Gp2D, GP2d, GP2D
OCI-AML3: -5.85 (log10 µM)
Synonyms: OCI-AML3, OCIAML3
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
tretinoin:navitoclax (4:1 mol/mol): AAC
AAC
Tissues
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
salivary_gland
salivary_gland
ovary
ovary
pancreas
pancreas
urinary_tract
urinary_tract
skin
skin
central_nervous_system
central_nervous_system
large_intestine
large_intestine
thyroid
thyroid
endometrium
endometrium
breast
breast
pleura
pleura
prostate
prostate
oesophagus
oesophagus
cervix
cervix
soft_tissue
soft_tissue
kidney
kidney
upper_aerodigestive_tract
upper_aerodigestive_tract
liver
liver
unknown
unknown
lung
lung
stomach
stomach
bone
bone
biliary_tract
biliary_tract
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
autonomic_ganglia
autonomic_ganglia
-5.00
-4.00
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
5.00
6.00
salivary_gland
salivary_gland
cervix
cervix
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
autonomic_ganglia
autonomic_ganglia
stomach
stomach
lung
lung
liver
liver
kidney
kidney
bone
bone
breast
breast
thyroid
thyroid
biliary_tract
biliary_tract
soft_tissue
soft_tissue
central_nervous_system
central_nervous_system
pleura
pleura
pancreas
pancreas
skin
skin
endometrium
endometrium
large_intestine
large_intestine
unknown
unknown
urinary_tract
urinary_tract
prostate
prostate
upper_aerodigestive_tract
upper_aerodigestive_tract
ovary
ovary
oesophagus
oesophagus
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to tretinoin:navitoclax (4:1 mol/mol)
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
CCSER1
CTRPv2
pan-cancer
AAC
0.11
0.002
mRNA
DOCK3
CTRPv2
pan-cancer
AAC
0.11
0.002
mRNA
ZC3H4
CTRPv2
pan-cancer
AAC
0.12
0.002
mRNA
TARS
CTRPv2
pan-cancer
AAC
-0.11
0.002
mRNA
PGAM2
CTRPv2
pan-cancer
AAC
0.11
0.002
mRNA
STARD7
CTRPv2
pan-cancer
AAC
0.12
0.002
mRNA
NAALADL1
CTRPv2
pan-cancer
AAC
0.11
0.002
mRNA
FYN
CTRPv2
pan-cancer
AAC
0.11
0.002
mRNA
ATP2B2
CTRPv2
pan-cancer
AAC
0.11
0.002
mRNA
CREB1
CTRPv2
pan-cancer
AAC
0.12
0.002
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