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ruxolitinib

Synonyms

SourcesNames Used
GDSC1000Ruxolitinib
CTRPv2ruxolitinib
PharmacoGx ruxolitinib

External IDs

DatabaseIdentifier
Smiles: N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Pubchem: 25126798

Annotated Targets

JAK2, JAK1, JAK3, TYK2

FDA Approval Status

Approved
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Top molecular features associated with response to ruxolitinib


Feature TypeStandardized
Nominal ANOVA
mRNA TFR2 CTRPv2 pan-cancer AAC 0.32 7e-21
mRNA UROD CTRPv2 pan-cancer AAC 0.31 1e-20
mRNA GJA4 CTRPv2 pan-cancer AAC 0.3 4e-20
mRNA MORC3 CTRPv2 pan-cancer AAC 0.31 4e-20
mRNA NTRK1 CTRPv2 pan-cancer AAC 0.32 7e-20
mRNA GBP5 CTRPv2 pan-cancer AAC 0.3 7e-20
mRNA GATA1 GDSC1000 pan-cancer AAC 0.3 7e-20
mRNA SIGLEC8 CTRPv2 pan-cancer AAC 0.31 1e-19
mRNA DHH CTRPv2 pan-cancer AAC 0.3 1e-19
mRNA GYPB GDSC1000 pan-cancer AAC 0.29 1e-19
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