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ruxolitinib

Synonyms

SourcesNames Used
GDSC1000Ruxolitinib
CTRPv2ruxolitinib
PharmacoGx ruxolitinib

External IDs

DatabaseIdentifier
Smiles: N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Pubchem: 25126798

Annotated Targets

JAK2, JAK1, JAK3, TYK2

FDA Approval Status

Approved
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Top molecular features associated with response to ruxolitinib


Feature TypeStandardized
Nominal ANOVA
mRNA ICOS CTRPv2 pan-cancer AAC 0.22 1e-11
mRNA ABCC4 CTRPv2 pan-cancer AAC 0.24 1e-11
mRNA IL7 CTRPv2 pan-cancer AAC 0.23 2e-11
mRNA IRF8 GDSC1000 pan-cancer AAC -0.27 2e-11
mRNA FAM65C CTRPv2 pan-cancer AAC 0.23 2e-11
mRNA GYPE CTRPv2 pan-cancer AAC 0.23 2e-11
mRNA LRRC7 GDSC1000 pan-cancer AAC 0.22 2e-11
mRNA ADORA3 CTRPv2 pan-cancer AAC 0.23 2e-11
mRNA DNAJC6 GDSC1000 pan-cancer AAC 0.23 3e-11
mRNA BLK GDSC1000 pan-cancer AAC -0.27 3e-11
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