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ruxolitinib

ruxolitinib

Synonyms

Sources	Names Used
GDSC1000	Ruxolitinib
CTRPv2	ruxolitinib
PharmacoGx	ruxolitinib

External IDs

Database	Identifier
Smiles:	N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Pubchem:	25126798

Annotated Targets

JAK2, JAK1, JAK3, TYK2

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to ruxolitinib

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TM6SF1	GDSC1000	pan-cancer	AAC	0.1	0.004
mRNA	ZBTB14	GDSC1000	pan-cancer	AAC	-0.099	0.004
mRNA	FAM127A	GDSC1000	pan-cancer	AAC	0.13	0.004
mRNA	SYPL1	GDSC1000	pan-cancer	AAC	-0.1	0.004
mRNA	TIGAR	GDSC1000	pan-cancer	AAC	-0.097	0.004
mRNA	TTC7B	GDSC1000	pan-cancer	AAC	0.1	0.004
mRNA	MAPKAPK2	GDSC1000	pan-cancer	AAC	0.098	0.004
mRNA	TMEM261	GDSC1000	pan-cancer	AAC	0.095	0.004
mRNA	RGS9	GDSC1000	pan-cancer	AAC	0.095	0.004
mRNA	PXT1	GDSC1000	pan-cancer	AAC	-0.097	0.004

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