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ruxolitinib

Synonyms

SourcesNames Used
GDSC1000Ruxolitinib
CTRPv2ruxolitinib
PharmacoGx ruxolitinib

External IDs

DatabaseIdentifier
Smiles: N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Pubchem: 25126798

Annotated Targets

JAK2, JAK1, JAK3, TYK2

FDA Approval Status

Approved
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Top molecular features associated with response to ruxolitinib


Feature TypeStandardized
Nominal ANOVA
mRNA CDR2 GDSC1000 pan-cancer AAC -0.11 0.002
mRNA PLEK GDSC1000 pan-cancer AAC -0.14 0.002
mRNA LMBR1L CTRPv2 pan-cancer AAC 0.11 0.002
mRNA AFF2 CTRPv2 pan-cancer AAC -0.11 0.002
mRNA OR4N2 GDSC1000 pan-cancer AAC -0.1 0.002
mRNA LLNLF-187D8.1 CTRPv2 pan-cancer AAC 0.11 0.002
mRNA E2F1 CTRPv2 pan-cancer AAC -0.11 0.002
mRNA PPP2R3B GDSC1000 pan-cancer AAC -0.11 0.002
mRNA LRRC28 CTRPv2 pan-cancer AAC -0.11 0.002
mRNA BCL11A GDSC1000 pan-cancer AAC -0.12 0.002
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