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ruxolitinib

Synonyms

SourcesNames Used
GDSC1000Ruxolitinib
CTRPv2ruxolitinib
PharmacoGx ruxolitinib

External IDs

DatabaseIdentifier
Smiles: N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Pubchem: 25126798

Annotated Targets

JAK2, JAK1, JAK3, TYK2

FDA Approval Status

Approved
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Top molecular features associated with response to ruxolitinib


Feature TypeStandardized
Nominal ANOVA
mRNA OSBPL6 CTRPv2 pan-cancer AAC 0.21 8e-10
mRNA DCAF15 CTRPv2 pan-cancer AAC 0.24 8e-10
mRNA NUTM2A CTRPv2 pan-cancer AAC 0.21 8e-10
mRNA CNRIP1 CTRPv2 pan-cancer AAC 0.22 9e-10
mRNA FHL3 CTRPv2 pan-cancer AAC 0.21 1e-09
mRNA HPGDS CTRPv2 pan-cancer AAC 0.2 1e-09
mRNA EVI2A GDSC1000 pan-cancer AAC -0.25 1e-09
mRNA SLFN14 CTRPv2 pan-cancer AAC 0.21 1e-09
mRNA C7orf34 CTRPv2 pan-cancer AAC 0.21 1e-09
mRNA DOK3 GDSC1000 pan-cancer AAC -0.28 1e-09
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