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OSI-930

OSI-930

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	OSI-930
PharmacoGx	OSI-930

External IDs

Database	Identifier
Smiles:	FC(F)(F)Oc1ccc(NC(=O)c2sccc2NCc2ccnc3ccccc23)cc1
Pubchem:	9868037

Annotated Targets

KIT, KDR, FLT1

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-930

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	DOT1L	CTRPv2	pan-cancer	AAC	0.26	2e-08
mRNA	NFATC3	CTRPv2	pan-cancer	AAC	0.26	2e-08
mRNA	SFPQ	CTRPv2	pan-cancer	AAC	0.21	3e-08
mRNA	CPSF6	CTRPv2	pan-cancer	AAC	0.22	4e-08
mRNA	HDAC2	CTRPv2	pan-cancer	AAC	0.2	5e-08
mRNA	FAM117B	CTRPv2	pan-cancer	AAC	0.21	6e-08
mRNA	ZNF445	CTRPv2	pan-cancer	AAC	0.22	7e-08
mRNA	N4BP2	CTRPv2	pan-cancer	AAC	0.21	1e-07
mRNA	ARHGAP19	CTRPv2	pan-cancer	AAC	0.23	1e-07
mRNA	ZNF124	CTRPv2	pan-cancer	AAC	0.21	2e-07

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