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OSI-930

OSI-930

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	OSI-930
PharmacoGx	OSI-930

External IDs

Database	Identifier
Smiles:	FC(F)(F)Oc1ccc(NC(=O)c2sccc2NCc2ccnc3ccccc23)cc1
Pubchem:	9868037

Annotated Targets

KIT, KDR, FLT1

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-930

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	HCFC1	CTRPv2	pan-cancer	AAC	0.24	3e-09
mRNA	PRTN3	GDSC1000	pan-cancer	AAC	0.24	6e-13
mRNA	AIF1	GDSC1000	pan-cancer	AAC	0.25	9e-10
mRNA	ARHGAP19-SLIT1	CTRPv2	pan-cancer	AAC	0.25	9e-09
mRNA	KLHL23	CTRPv2	pan-cancer	AAC	0.25	2e-10
mRNA	CD300LF	GDSC1000	pan-cancer	AAC	0.26	7e-13
mRNA	NFATC3	CTRPv2	pan-cancer	AAC	0.26	2e-08
mRNA	PRAM1	GDSC1000	pan-cancer	AAC	0.26	2e-13
mRNA	PRSS57	GDSC1000	pan-cancer	AAC	0.26	2e-12
mRNA	DOT1L	CTRPv2	pan-cancer	AAC	0.26	2e-08

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