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ZSTK474

ZSTK474

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	ZSTK474
PharmacoGx	ZSTK474

External IDs

Database	Identifier
Smiles:	FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
Pubchem:	11647372

Annotated Targets

PIK3CD, PIK3CB, PIK3CG

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to ZSTK474

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MAP4K1	CTRPv2	pan-cancer	AAC	0.2	3e-05
mRNA	HCLS1	CTRPv2	pan-cancer	AAC	0.2	0.0009
mRNA	HVCN1	CTRPv2	pan-cancer	AAC	0.21	6e-07
mRNA	HVCN1	GDSC1000	pan-cancer	AAC	0.21	4e-07
mRNA	EAF2	CTRPv2	pan-cancer	AAC	0.21	9e-06
mRNA	NLRC3	GDSC1000	pan-cancer	AAC	0.21	4e-06
mRNA	ARHGAP15	GDSC1000	pan-cancer	AAC	0.22	0.001
mRNA	P2RY8	CTRPv2	pan-cancer	AAC	0.22	1e-05
mRNA	BMF	CTRPv2	pan-cancer	AAC	0.22	4e-09
mRNA	DOCK8	GDSC1000	pan-cancer	AAC	0.22	1e-06

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