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ZSTK474

ZSTK474

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	ZSTK474
PharmacoGx	ZSTK474

External IDs

Database	Identifier
Smiles:	FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
Pubchem:	11647372

Annotated Targets

PIK3CD, PIK3CB, PIK3CG

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to ZSTK474

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MEF2D	CTRPv2	pan-cancer	AAC	0.11	0.007
mRNA	PBLD	CTRPv2	pan-cancer	AAC	0.11	0.007
mRNA	SNX20	CTRPv2	pan-cancer	AAC	0.12	0.007
mRNA	TRA2A	CTRPv2	pan-cancer	AAC	0.1	0.007
mRNA	TSC22D4	CTRPv2	pan-cancer	AAC	0.11	0.007
mRNA	PFN2	GDSC1000	pan-cancer	AAC	-0.099	0.007
mRNA	TMED5	GDSC1000	pan-cancer	AAC	-0.083	0.007
mRNA	P2RY10	CTRPv2	pan-cancer	AAC	0.11	0.007
mRNA	PITRM1	GDSC1000	pan-cancer	AAC	-0.083	0.007
mRNA	OSR2	GDSC1000	pan-cancer	AAC	0.087	0.007

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