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BRD-K55116708
BRD-K55116708
Synonyms
Sources
Names Used
CTRPv2
BRD-K55116708
PharmacoGx
BRD-K55116708
External IDs
Database
Identifier
Smiles:
C[C@@H](CO)N1C[C@@H](C)[C@@H](CN(C)Cc2ccc(cc2)C(=O)Nc3ccccc3N)Oc4c(NC(=O)Nc5ccccc5)cccc4C1=O
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
BRD-K55116708 (per dataset)
0
100
200
300
400
500
600
700
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
799
Download SVG
Number of tissues tested with
BRD-K55116708 (per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
BRD-K55116708: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
0.60
AM-38
AM-38
MHH-CALL-4
MHH-CALL-4
DOHH-2
DOHH-2
SEM
SEM
SKM-1
SKM-1
MES-SA
MES-SA
RPMI-8226
RPMI-8226
SU-DHL-8
SU-DHL-8
MV-4-11
MV-4-11
NB4
NB4
JK-1
JK-1
ALL-SIL
ALL-SIL
REH
REH
TALL-1
TALL-1
SUP-T1
SUP-T1
MOLT-13
MOLT-13
RCH-ACV
RCH-ACV
MONO-MAC-1
MONO-MAC-1
NOMO-1
NOMO-1
NUGC-4
NUGC-4
KMS-28BM
KMS-28BM
KARPAS-299
KARPAS-299
SNU-182
SNU-182
RI-1
RI-1
PL-21
PL-21
NCI-H2106
NCI-H2106
MOLM-13
MOLM-13
EM-2
EM-2
ECC10
ECC10
SNU-1079
SNU-1079
NH-6
NH-6
FTC-238
FTC-238
IA-LM
IA-LM
RCM-1
RCM-1
BT-549
BT-549
HeLa
HeLa
OE19
OE19
EoL-1-cell
EoL-1-cell
MOLT-3
MOLT-3
Pfeiffer
Pfeiffer
SUP-M2
SUP-M2
COLO-829
COLO-829
DAN-G
DAN-G
HCC1500
HCC1500
NCI-H841
NCI-H841
U-118-MG
U-118-MG
Becker
Becker
SK-N-MC
SK-N-MC
VMRC-RCZ
VMRC-RCZ
TT2609-C02
TT2609-C02
G-402
G-402
TOV-21G
TOV-21G
647-V
647-V
A2058
A2058
CAL-27
CAL-27
IST-MES1
IST-MES1
SK-MEL-24
SK-MEL-24
JHOS-2
JHOS-2
HCC-56
HCC-56
WM-88
WM-88
AM-38
MHH-CALL-4
DOHH-2
SEM
SKM-1
MES-SA
RPMI-8226
SU-DHL-8
MV-4-11
NB4
JK-1
ALL-SIL
REH
TALL-1
SUP-T1
MOLT-13
RCH-ACV
MONO-MAC-1
NOMO-1
NUGC-4
KMS-28BM
KARPAS-299
SNU-182
RI-1
PL-21
NCI-H2106
MOLM-13
EM-2
ECC10
SNU-1079
NH-6
FTC-238
IA-LM
RCM-1
BT-549
HeLa
OE19
EoL-1-cell
MOLT-3
Pfeiffer
SUP-M2
COLO-829
DAN-G
HCC1500
NCI-H841
U-118-MG
Becker
SK-N-MC
VMRC-RCZ
TT2609-C02
G-402
TOV-21G
647-V
A2058
CAL-27
IST-MES1
SK-MEL-24
JHOS-2
HCC-56
WM-88
AM-38: 0.62
Synonyms: AM-38, AM38
MHH-CALL-4: 0.51
Synonyms: MHH-CALL-4, MHHCALL4
DOHH-2: 0.47
Synonyms: DOHH-2, DOHH2
SEM: 0.47
Synonyms: SEM
SKM-1: 0.47
Synonyms: SKM-1, SKM1
MES-SA: 0.46
Synonyms: MES-SA, MESSA
RPMI-8226: 0.44
Synonyms: RPMI-8226, RPMI 8226, RPMI_8226, RPMI8226
SU-DHL-8: 0.44
Synonyms: SU-DHL-8, SUDHL8
MV-4-11: 0.43
Synonyms: MV-4-11, MV411
NB4: 0.41
Synonyms: NB4, NB-4
JK-1: 0.40
Synonyms: JK-1, JK1
ALL-SIL: 0.39
Synonyms: ALL-SIL, ALLSIL
REH: 0.38
Synonyms: REH, Reh
TALL-1: 0.38
Synonyms: TALL-1, TALL1
SUP-T1: 0.38
Synonyms: SUP-T1, SUPT1
MOLT-13: 0.37
Synonyms: MOLT-13, MOLT13
RCH-ACV: 0.36
Synonyms: RCH-ACV, RCHACV
MONO-MAC-1: 0.36
Synonyms: MONO-MAC-1, MONOMAC1
NOMO-1: 0.35
Synonyms: NOMO-1, NOMO1
NUGC-4: 0.34
Synonyms: NUGC-4, NUGC4
KMS-28BM: 0.34
Synonyms: KMS-28BM, KMS28BM
KARPAS-299: 0.34
Synonyms: KARPAS-299, KARPAS299
SNU-182: 0.34
Synonyms: SNU-182, SNU182
RI-1: 0.34
Synonyms: RI-1, RI1
PL-21: 0.34
Synonyms: PL-21, PL21
NCI-H2106: 0.33
Synonyms: NCI-H2106, NCIH2106
MOLM-13: 0.33
Synonyms: MOLM-13, MOLM13
EM-2: 0.33
Synonyms: EM-2, EM2
ECC10: 0.33
Synonyms: ECC10
SNU-1079: 0.33
Synonyms: SNU-1079, SNU1079
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
NH-6: 0.00
Synonyms: NH-6, NH6
FTC-238: 0.00
Synonyms: FTC-238, FTC238
IA-LM: 0.00
Synonyms: IA-LM, IALM
RCM-1: 0.00
Synonyms: RCM-1, RCM1
BT-549: 0.00
Synonyms: BT-549, BT549, bt549
HeLa: 0.00
Synonyms: HeLa, HELA
OE19: 0.00
Synonyms: OE19
EoL-1-cell: 0.00
Synonyms: EoL-1-cell, EOL-1, EOL1
MOLT-3: 0.00
Synonyms: MOLT-3, MOLT3
Pfeiffer: 0.00
Synonyms: Pfeiffer, PFEIFFER
SUP-M2: 0.00
Synonyms: SUP-M2, SUPM2
COLO-829: 0.00
Synonyms: COLO-829, COLO 829, COLO_829, COLO829
DAN-G: 0.00
Synonyms: DAN-G, DANG
HCC1500: 0.00
Synonyms: HCC1500, hcc1500
NCI-H841: 0.00
Synonyms: NCI-H841, NCIH841
U-118-MG: 0.00
Synonyms: U-118-MG, U-118 MG, U-118_MG, U118MG
Becker: 0.00
Synonyms: Becker, BECKER
SK-N-MC: 0.00
Synonyms: SK-N-MC, SKNMC
VMRC-RCZ: 0.00
Synonyms: VMRC-RCZ, VMRCRCZ
TT2609-C02: 0.00
Synonyms: TT2609-C02, TT2609C02
G-402: 0.00
Synonyms: G-402, G402
TOV-21G: 0.00
Synonyms: TOV-21G, TOV21G
647-V: 0.00
Synonyms: 647-V, 647V
A2058: 0.00
Synonyms: A2058
CAL-27: 0.00
Synonyms: CAL-27, CAL 27, CAL_27, CAL27
IST-MES1: 0.00
Synonyms: IST-MES1, ISTMES1
SK-MEL-24: 0.00
Synonyms: SK-MEL-24, SKMEL24
JHOS-2: 0.00
Synonyms: JHOS-2, JHOS2
HCC-56: 0.00
Synonyms: HCC-56, HCC56
WM-88: 0.00
Synonyms: WM-88, WM88
Download SVG
0.00
1.00
2.00
3.00
4.00
5.00
6.00
PSN1
PSN1
HCT-8
HCT-8
KASUMI-1
KASUMI-1
VCaP
VCaP
Daudi
Daudi
NCI-H2081
NCI-H2081
DV-90
DV-90
A3-KAW
A3-KAW
NCI-H727
NCI-H727
LK-2
LK-2
KATOIII
KATOIII
BT330
BT330
SUP-HD1
SUP-HD1
NCI-H1563
NCI-H1563
SK-LU-1
SK-LU-1
TE 441.T
TE 441.T
OCI-AML3
OCI-AML3
P3HR-1
P3HR-1
HCC-1171
HCC-1171
KPL-1
KPL-1
SNU-119
SNU-119
DB
DB
OPM-2
OPM-2
NCI-H460
NCI-H460
OVTOKO
OVTOKO
BT340
BT340
HuG1-N
HuG1-N
SNB75
SNB75
JeKo-1
JeKo-1
BT440
BT440
KMS-28BM
KMS-28BM
RS4;11
RS4;11
EM-2
EM-2
NCI-H2106
NCI-H2106
PL-21
PL-21
Ki-JK
Ki-JK
NUGC-4
NUGC-4
RI-1
RI-1
ECC10
ECC10
RT-112
RT-112
KARPAS-299
KARPAS-299
NOMO-1
NOMO-1
MOLM-13
MOLM-13
KP-N-S19s
KP-N-S19s
RCH-ACV
RCH-ACV
MONO-MAC-1
MONO-MAC-1
MOLT-13
MOLT-13
SUP-T1
SUP-T1
ALL-SIL
ALL-SIL
JK-1
JK-1
REH
REH
TALL-1
TALL-1
NB4
NB4
RPMI-8226
RPMI-8226
MV-4-11
MV-4-11
SU-DHL-8
SU-DHL-8
SEM
SEM
DOHH-2
DOHH-2
SKM-1
SKM-1
MHH-CALL-4
MHH-CALL-4
PSN1
HCT-8
KASUMI-1
VCaP
Daudi
NCI-H2081
DV-90
A3-KAW
NCI-H727
LK-2
KATOIII
BT330
SUP-HD1
NCI-H1563
SK-LU-1
TE 441.T
OCI-AML3
P3HR-1
HCC-1171
KPL-1
SNU-119
DB
OPM-2
NCI-H460
OVTOKO
BT340
HuG1-N
SNB75
JeKo-1
BT440
KMS-28BM
RS4;11
EM-2
NCI-H2106
PL-21
Ki-JK
NUGC-4
RI-1
ECC10
RT-112
KARPAS-299
NOMO-1
MOLM-13
KP-N-S19s
RCH-ACV
MONO-MAC-1
MOLT-13
SUP-T1
ALL-SIL
JK-1
REH
TALL-1
NB4
RPMI-8226
MV-4-11
SU-DHL-8
SEM
DOHH-2
SKM-1
MHH-CALL-4
PSN1: 6.27 (log10 µM)
Synonyms: PSN1
HCT-8: 6.00 (log10 µM)
Synonyms: HCT-8, HCT8
KASUMI-1: 5.99 (log10 µM)
Synonyms: KASUMI-1, Kasumi-1, KASUMI1
VCaP: 5.06 (log10 µM)
Synonyms: VCaP, VCAP
Daudi: 4.65 (log10 µM)
Synonyms: Daudi, DAUDI
NCI-H2081: 4.63 (log10 µM)
Synonyms: NCI-H2081, NCIH2081
DV-90: 4.44 (log10 µM)
Synonyms: DV-90, DV90
A3-KAW: 4.35 (log10 µM)
Synonyms: A3-KAW, A3/KAW, A3_KAW, A3KAW
NCI-H727: 4.07 (log10 µM)
Synonyms: NCI-H727, NCIH727
LK-2: 4.04 (log10 µM)
Synonyms: LK-2, LK2
KATOIII: 3.98 (log10 µM)
Synonyms: KATOIII, KATO III, KATO_III
BT330: 3.77 (log10 µM)
Synonyms: BT330
SUP-HD1: 3.64 (log10 µM)
Synonyms: SUP-HD1, SUPHD1
NCI-H1563: 3.56 (log10 µM)
Synonyms: NCI-H1563, NCIH1563
SK-LU-1: 3.54 (log10 µM)
Synonyms: SK-LU-1, SKLU1
TE 441.T: 3.45 (log10 µM)
Synonyms: TE 441.T, TE_441.T, TE-441-T, TE441T
OCI-AML3: 3.37 (log10 µM)
Synonyms: OCI-AML3, OCIAML3
P3HR-1: 3.25 (log10 µM)
Synonyms: P3HR-1, P3HR1
HCC-1171: 3.09 (log10 µM)
Synonyms: HCC-1171, HCC1171
KPL-1: 3.04 (log10 µM)
Synonyms: KPL-1, KPL1, kpl1
SNU-119: 2.90 (log10 µM)
Synonyms: SNU-119, SNU119
DB: 2.89 (log10 µM)
Synonyms: DB
OPM-2: 2.82 (log10 µM)
Synonyms: OPM-2, OPM2
NCI-H460: 2.66 (log10 µM)
Synonyms: NCI-H460, NCIH460
OVTOKO: 2.64 (log10 µM)
Synonyms: OVTOKO
BT340: 2.64 (log10 µM)
Synonyms: BT340
HuG1-N: 2.45 (log10 µM)
Synonyms: HuG1-N, HUG1N
SNB75: 2.44 (log10 µM)
Synonyms: SNB75
JeKo-1: 2.43 (log10 µM)
Synonyms: JeKo-1, JEKO-1, JEKO1
BT440: 2.21 (log10 µM)
Synonyms: BT440
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
KMS-28BM: 0.33 (log10 µM)
Synonyms: KMS-28BM, KMS28BM
RS4;11: 0.33 (log10 µM)
Synonyms: RS4;11, RS4_11, RS4-11, RS411
EM-2: 0.32 (log10 µM)
Synonyms: EM-2, EM2
NCI-H2106: 0.31 (log10 µM)
Synonyms: NCI-H2106, NCIH2106
PL-21: 0.31 (log10 µM)
Synonyms: PL-21, PL21
Ki-JK: 0.30 (log10 µM)
Synonyms: Ki-JK, KIJK
NUGC-4: 0.29 (log10 µM)
Synonyms: NUGC-4, NUGC4
RI-1: 0.29 (log10 µM)
Synonyms: RI-1, RI1
ECC10: 0.27 (log10 µM)
Synonyms: ECC10
RT-112: 0.27 (log10 µM)
Synonyms: RT-112, RT112
KARPAS-299: 0.24 (log10 µM)
Synonyms: KARPAS-299, KARPAS299
NOMO-1: 0.23 (log10 µM)
Synonyms: NOMO-1, NOMO1
MOLM-13: 0.21 (log10 µM)
Synonyms: MOLM-13, MOLM13
KP-N-S19s: 0.19 (log10 µM)
Synonyms: KP-N-S19s, KP-N-SI9s, KPNSI9S
RCH-ACV: 0.19 (log10 µM)
Synonyms: RCH-ACV, RCHACV
MONO-MAC-1: 0.13 (log10 µM)
Synonyms: MONO-MAC-1, MONOMAC1
MOLT-13: 0.12 (log10 µM)
Synonyms: MOLT-13, MOLT13
SUP-T1: 0.11 (log10 µM)
Synonyms: SUP-T1, SUPT1
ALL-SIL: 0.06 (log10 µM)
Synonyms: ALL-SIL, ALLSIL
JK-1: 0.02 (log10 µM)
Synonyms: JK-1, JK1
REH: 0.02 (log10 µM)
Synonyms: REH, Reh
TALL-1: -0.03 (log10 µM)
Synonyms: TALL-1, TALL1
NB4: -0.08 (log10 µM)
Synonyms: NB4, NB-4
RPMI-8226: -0.20 (log10 µM)
Synonyms: RPMI-8226, RPMI 8226, RPMI_8226, RPMI8226
MV-4-11: -0.25 (log10 µM)
Synonyms: MV-4-11, MV411
SU-DHL-8: -0.26 (log10 µM)
Synonyms: SU-DHL-8, SUDHL8
SEM: -0.29 (log10 µM)
Synonyms: SEM
DOHH-2: -0.30 (log10 µM)
Synonyms: DOHH-2, DOHH2
SKM-1: -0.36 (log10 µM)
Synonyms: SKM-1, SKM1
MHH-CALL-4: -0.59 (log10 µM)
Synonyms: MHH-CALL-4, MHHCALL4
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
BRD-K55116708: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
0.60
cervix
cervix
liver
liver
prostate
prostate
skin
skin
kidney
kidney
pancreas
pancreas
large_intestine
large_intestine
pleura
pleura
autonomic_ganglia
autonomic_ganglia
unknown
unknown
ovary
ovary
central_nervous_system
central_nervous_system
endometrium
endometrium
bone
bone
lung
lung
upper_aerodigestive_tract
upper_aerodigestive_tract
breast
breast
thyroid
thyroid
soft_tissue
soft_tissue
urinary_tract
urinary_tract
biliary_tract
biliary_tract
oesophagus
oesophagus
stomach
stomach
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
salivary_gland
salivary_gland
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
5.00
cervix
cervix
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
autonomic_ganglia
autonomic_ganglia
bone
bone
prostate
prostate
soft_tissue
soft_tissue
stomach
stomach
breast
breast
salivary_gland
salivary_gland
upper_aerodigestive_tract
upper_aerodigestive_tract
endometrium
endometrium
thyroid
thyroid
central_nervous_system
central_nervous_system
oesophagus
oesophagus
urinary_tract
urinary_tract
lung
lung
pancreas
pancreas
ovary
ovary
biliary_tract
biliary_tract
skin
skin
liver
liver
pleura
pleura
large_intestine
large_intestine
unknown
unknown
kidney
kidney
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to BRD-K55116708
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
NCF4
CTRPv2
pan-cancer
AAC
0.085
0.05
mRNA
HIPK1
CTRPv2
pan-cancer
AAC
0.075
0.05
mRNA
MGST3
CTRPv2
pan-cancer
AAC
-0.077
0.05
mRNA
ABCA1
CTRPv2
pan-cancer
AAC
0.078
0.05
mRNA
REXO2
CTRPv2
pan-cancer
AAC
-0.074
0.05
mRNA
RBPJ
CTRPv2
pan-cancer
AAC
0.074
0.05
mRNA
MVB12B
CTRPv2
pan-cancer
AAC
0.073
0.05
mRNA
ZNF518A
CTRPv2
pan-cancer
AAC
0.08
0.05
mRNA
TBC1D28
CTRPv2
pan-cancer
AAC
0.073
0.05
mRNA
PTPMT1
CTRPv2
pan-cancer
AAC
-0.073
0.05
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