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BRD-K27224038
BRD-K27224038
Synonyms
Sources
Names Used
CTRPv2
BRD-K27224038
PharmacoGx
BRD-K27224038
External IDs
Database
Identifier
Smiles:
C[C@@H](CO)N1C[C@H](C)[C@@H](CN(C)C(=O)C2CCOCC2)Oc3ncc(C#CC4(O)CCCC4)cc3C1=O
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
BRD-K27224038 (per dataset)
0
20
40
60
80
100
120
140
160
180
200
220
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
228
Download SVG
Number of tissues tested with
BRD-K27224038 (per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
23
Download SVG
Dataset Select
all
CTRPv2
BRD-K27224038: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
SNU-81
SNU-81
5637
5637
KU812
KU812
NCI-H526
NCI-H526
SNU-C2A
SNU-C2A
NALM-6
NALM-6
NCO2
NCO2
RERF-LC-Ad1
RERF-LC-Ad1
BxPC-3
BxPC-3
SNU-1214
SNU-1214
LAMA-84
LAMA-84
U-2-OS
U-2-OS
SNU-1079
SNU-1079
DMS-79
DMS-79
HCC-1833
HCC-1833
253J
253J
HCC-2279
HCC-2279
MOLM-13
MOLM-13
RPMI-8402
RPMI-8402
CAS-1
CAS-1
EM-2
EM-2
NCI-H2291
NCI-H2291
NUGC-4
NUGC-4
COLO-741
COLO-741
KYSE-140
KYSE-140
SNU-1076
SNU-1076
PEER
PEER
HEL
HEL
SNU-719
SNU-719
NCI-H1734
NCI-H1734
BCPAP
BCPAP
SF126
SF126
SNU-119
SNU-119
HEC-59
HEC-59
639-V
639-V
ONCO-DG-1
ONCO-DG-1
ES-2
ES-2
CAL-62
CAL-62
HuCCT1
HuCCT1
RPMI-7951
RPMI-7951
CGTH-W-1
CGTH-W-1
ECC12
ECC12
HCC-95
HCC-95
SK-CO-1
SK-CO-1
CFPAC-1
CFPAC-1
HCC-78
HCC-78
KU-19-19
KU-19-19
COLO-205
COLO-205
MKN45
MKN45
8505C
8505C
SBC-5
SBC-5
CAMA-1
CAMA-1
Detroit562
Detroit562
Hep 3B2.1-7
Hep 3B2.1-7
HSC-3
HSC-3
U-87-MG
U-87-MG
CAL-12T
CAL-12T
HEC-108
HEC-108
HT-29
HT-29
MOR/CPR
MOR/CPR
SNU-81
5637
KU812
NCI-H526
SNU-C2A
NALM-6
NCO2
RERF-LC-Ad1
BxPC-3
SNU-1214
LAMA-84
U-2-OS
SNU-1079
DMS-79
HCC-1833
253J
HCC-2279
MOLM-13
RPMI-8402
CAS-1
EM-2
NCI-H2291
NUGC-4
COLO-741
KYSE-140
SNU-1076
PEER
HEL
SNU-719
NCI-H1734
BCPAP
SF126
SNU-119
HEC-59
639-V
ONCO-DG-1
ES-2
CAL-62
HuCCT1
RPMI-7951
CGTH-W-1
ECC12
HCC-95
SK-CO-1
CFPAC-1
HCC-78
KU-19-19
COLO-205
MKN45
8505C
SBC-5
CAMA-1
Detroit562
Hep 3B2.1-7
HSC-3
U-87-MG
CAL-12T
HEC-108
HT-29
MOR/CPR
SNU-81: 0.40
Synonyms: SNU-81, SNU81
5637: 0.18
Synonyms: 5637
KU812: 0.14
Synonyms: KU812
NCI-H526: 0.14
Synonyms: NCI-H526, NCIH526
SNU-C2A: 0.13
Synonyms: SNU-C2A, SNUC2A
NALM-6: 0.12
Synonyms: NALM-6, NALM6
NCO2: 0.11
Synonyms: NCO2
RERF-LC-Ad1: 0.11
Synonyms: RERF-LC-Ad1, RERFLCAD1
BxPC-3: 0.11
Synonyms: BxPC-3, BXPC3
SNU-1214: 0.11
Synonyms: SNU-1214, SNU1214
LAMA-84: 0.11
Synonyms: LAMA-84, LAMA84
U-2-OS: 0.10
Synonyms: U-2-OS, U-2 OS, U-2_OS, U2OS
SNU-1079: 0.10
Synonyms: SNU-1079, SNU1079
DMS-79: 0.10
Synonyms: DMS-79, DMS 79, DMS_79, DMS79
HCC-1833: 0.10
Synonyms: HCC-1833, HCC1833
253J: 0.09
Synonyms: 253J
HCC-2279: 0.09
Synonyms: HCC-2279, HCC2279
MOLM-13: 0.09
Synonyms: MOLM-13, MOLM13
RPMI-8402: 0.09
Synonyms: RPMI-8402, RPMI8402
CAS-1: 0.09
Synonyms: CAS-1, CAS1
EM-2: 0.09
Synonyms: EM-2, EM2
NCI-H2291: 0.09
Synonyms: NCI-H2291, NCIH2291
NUGC-4: 0.09
Synonyms: NUGC-4, NUGC4
COLO-741: 0.09
Synonyms: COLO-741, COLO 741, COLO_741, COLO741
KYSE-140: 0.08
Synonyms: KYSE-140, KYSE140
SNU-1076: 0.08
Synonyms: SNU-1076, SNU1076
PEER: 0.08
Synonyms: PEER
HEL: 0.08
Synonyms: HEL
SNU-719: 0.08
Synonyms: SNU-719, SNU719
NCI-H1734: 0.08
Synonyms: NCI-H1734, NCIH1734
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
BCPAP: 0.00
Synonyms: BCPAP, B-CPAP
SF126: 0.00
Synonyms: SF126
SNU-119: 0.00
Synonyms: SNU-119, SNU119
HEC-59: 0.00
Synonyms: HEC-59, HEC59
639-V: 0.00
Synonyms: 639-V, 639V
ONCO-DG-1: 0.00
Synonyms: ONCO-DG-1, ONCODG1
ES-2: 0.00
Synonyms: ES-2, ES2
CAL-62: 0.00
Synonyms: CAL-62, CAL62
HuCCT1: 0.00
Synonyms: HuCCT1, HUCCT1
RPMI-7951: 0.00
Synonyms: RPMI-7951, RPMI7951
CGTH-W-1: 0.00
Synonyms: CGTH-W-1, CGTHW1
ECC12: 0.00
Synonyms: ECC12
HCC-95: 0.00
Synonyms: HCC-95, HCC95
SK-CO-1: 0.00
Synonyms: SK-CO-1, SKCO1
CFPAC-1: 0.00
Synonyms: CFPAC-1, CFPAC1
HCC-78: 0.00
Synonyms: HCC-78, HCC78
KU-19-19: 0.00
Synonyms: KU-19-19, KU1919
COLO-205: 0.00
Synonyms: COLO-205, COLO 205, COLO205
MKN45: 0.00
Synonyms: MKN45, MKN-45
8505C: 0.00
Synonyms: 8505C
SBC-5: 0.00
Synonyms: SBC-5, SBC5
CAMA-1: 0.00
Synonyms: CAMA-1, CAMA1, cama1
Detroit562: 0.00
Synonyms: Detroit562, Detroit 562, Detroit_562, DETROIT562
Hep 3B2.1-7: 0.00
Synonyms: Hep 3B2.1-7, Hep_3B2.1-7, Hep3B2-1-7, Hep 3B2_1-7, Hep_3B2_1-7, HEP3B217
HSC-3: 0.00
Synonyms: HSC-3, HSC3
U-87-MG: 0.00
Synonyms: U-87-MG, U-87 MG, U-87_MG, U87MG
CAL-12T: 0.00
Synonyms: CAL-12T, CAL12T
HEC-108: 0.00
Synonyms: HEC-108, HEC108
HT-29: 0.00
Synonyms: HT-29, HT29
MOR/CPR: 0.00
Synonyms: MOR/CPR, MOR_CPR, MORCPR
Download SVG
3.00
4.00
5.00
6.00
7.00
8.00
9.00
10.00
11.00
12.00
13.00
LAMA-84
LAMA-84
SNU-878
SNU-878
SNU-620
SNU-620
HDLM-2
HDLM-2
VM-CUB-1
VM-CUB-1
RERF-LC-AI
RERF-LC-AI
LN-18
LN-18
NCI-H1155
NCI-H1155
HT
HT
DOV13
DOV13
LAMA-84
SNU-878
SNU-620
HDLM-2
VM-CUB-1
RERF-LC-AI
LN-18
NCI-H1155
HT
DOV13
LAMA-84: 13.33 (log10 µM)
Synonyms: LAMA-84, LAMA84
SNU-878: 7.61 (log10 µM)
Synonyms: SNU-878, SNU878
SNU-620: 5.44 (log10 µM)
Synonyms: SNU-620, SNU620
HDLM-2: 5.36 (log10 µM)
Synonyms: HDLM-2, HDLM2
VM-CUB-1: 3.45 (log10 µM)
Synonyms: VM-CUB-1, VM-CUB1, VMCUB1
RERF-LC-AI: 2.47 (log10 µM)
Synonyms: RERF-LC-AI, RERFLCAI
LN-18: 2.32 (log10 µM)
Synonyms: LN-18, LN18
NCI-H1155: 2.29 (log10 µM)
Synonyms: NCI-H1155, NCIH1155
HT: 2.10 (log10 µM)
Synonyms: HT
DOV13: 2.09 (log10 µM)
Synonyms: DOV13
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
BRD-K27224038: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
thyroid
thyroid
large_intestine
large_intestine
biliary_tract
biliary_tract
skin
skin
urinary_tract
urinary_tract
ovary
ovary
breast
breast
endometrium
endometrium
central_nervous_system
central_nervous_system
stomach
stomach
pleura
pleura
upper_aerodigestive_tract
upper_aerodigestive_tract
lung
lung
liver
liver
pancreas
pancreas
oesophagus
oesophagus
kidney
kidney
salivary_gland
salivary_gland
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
bone
bone
autonomic_ganglia
autonomic_ganglia
soft_tissue
soft_tissue
prostate
prostate
0.00
1.00
2.00
3.00
4.00
5.00
6.00
7.00
8.00
9.00
10.00
11.00
central_nervous_system
central_nervous_system
breast
breast
urinary_tract
urinary_tract
stomach
stomach
thyroid
thyroid
biliary_tract
biliary_tract
skin
skin
autonomic_ganglia
autonomic_ganglia
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
liver
liver
kidney
kidney
pleura
pleura
oesophagus
oesophagus
soft_tissue
soft_tissue
lung
lung
upper_aerodigestive_tract
upper_aerodigestive_tract
large_intestine
large_intestine
pancreas
pancreas
ovary
ovary
endometrium
endometrium
bone
bone
prostate
prostate
salivary_gland
salivary_gland
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to BRD-K27224038
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
NDUFAF2
CTRPv2
pan-cancer
AAC
-0.14
0.07
mRNA
LYRM9
CTRPv2
pan-cancer
AAC
0.13
0.07
mRNA
PHACTR3
CTRPv2
pan-cancer
AAC
0.13
0.07
mRNA
C1orf122
CTRPv2
pan-cancer
AAC
0.15
0.07
mRNA
MRPL11
CTRPv2
pan-cancer
AAC
-0.14
0.07
mRNA
SPRR1A
CTRPv2
pan-cancer
AAC
0.13
0.07
mRNA
CEP95
CTRPv2
pan-cancer
AAC
0.14
0.07
mRNA
HPS1
CTRPv2
pan-cancer
AAC
0.15
0.07
mRNA
SGO1
CTRPv2
pan-cancer
AAC
-0.14
0.07
mRNA
SMIM17
CTRPv2
pan-cancer
AAC
0.13
0.07
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