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BRD-K71935468
BRD-K71935468
Synonyms
Sources
Names Used
CTRPv2
BRD-K71935468
PharmacoGx
BRD-K71935468
External IDs
Database
Identifier
Smiles:
COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
BRD-K71935468 (per dataset)
0
100
200
300
400
500
600
700
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
798
Download SVG
Number of tissues tested with
BRD-K71935468 (per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
24
Download SVG
Dataset Select
all
CTRPv2
BRD-K71935468: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
BT159
BT159
MONO-MAC-1
MONO-MAC-1
BT-474
BT-474
Hs 888.T
Hs 888.T
BT239
BT239
HCC2935
HCC2935
AML-193
AML-193
NCI-H2106
NCI-H2106
BT286
BT286
BT139
BT139
DEL
DEL
BT231
BT231
EM-2
EM-2
BT228
BT228
KMS-34
KMS-34
LCLC-97TM1
LCLC-97TM1
BT504
BT504
NCI-H1155
NCI-H1155
RS4;11
RS4;11
BT340
BT340
EoL-1-cell
EoL-1-cell
KMS-21BM
KMS-21BM
HT-1376
HT-1376
BT422
BT422
MOLM-13
MOLM-13
Hs 822.T
Hs 822.T
BT248
BT248
Hs-578-T
Hs-578-T
BT12
BT12
NCI-H1694
NCI-H1694
HCC-95
HCC-95
WSU-DLCL2
WSU-DLCL2
SNU-201
SNU-201
HSC-3
HSC-3
HEL
HEL
LAMA-84
LAMA-84
NCI-H2030
NCI-H2030
NCI-H2228
NCI-H2228
FU-OV-1
FU-OV-1
SK-MEL-5
SK-MEL-5
LC-1/sq-SF
LC-1/sq-SF
GI-1
GI-1
LU-65
LU-65
T98G
T98G
TT2609-C02
TT2609-C02
Panc 02.03
Panc 02.03
SNU-475
SNU-475
Caki-2
Caki-2
huH-1
huH-1
KNS-42
KNS-42
PE/CA-PJ49
PE/CA-PJ49
NCI-H522
NCI-H522
JeKo-1
JeKo-1
IGR-37
IGR-37
KNS-62
KNS-62
CAL-33
CAL-33
HCC-1438
HCC-1438
KYSE-30
KYSE-30
OCI-AML5
OCI-AML5
NCI-H1651
NCI-H1651
BT159
MONO-MAC-1
BT-474
Hs 888.T
BT239
HCC2935
AML-193
NCI-H2106
BT286
BT139
DEL
BT231
EM-2
BT228
KMS-34
LCLC-97TM1
BT504
NCI-H1155
RS4;11
BT340
EoL-1-cell
KMS-21BM
HT-1376
BT422
MOLM-13
Hs 822.T
BT248
Hs-578-T
BT12
NCI-H1694
HCC-95
WSU-DLCL2
SNU-201
HSC-3
HEL
LAMA-84
NCI-H2030
NCI-H2228
FU-OV-1
SK-MEL-5
LC-1/sq-SF
GI-1
LU-65
T98G
TT2609-C02
Panc 02.03
SNU-475
Caki-2
huH-1
KNS-42
PE/CA-PJ49
NCI-H522
JeKo-1
IGR-37
KNS-62
CAL-33
HCC-1438
KYSE-30
OCI-AML5
NCI-H1651
BT159: 0.38
Synonyms: BT159
MONO-MAC-1: 0.37
Synonyms: MONO-MAC-1, MONOMAC1
BT-474: 0.36
Synonyms: BT-474, BT474, bt474
Hs 888.T: 0.34
Synonyms: Hs 888.T, Hs_888.T, HS888T
BT239: 0.32
Synonyms: BT239
HCC2935: 0.30
Synonyms: HCC2935
AML-193: 0.30
Synonyms: AML-193, AML193
NCI-H2106: 0.30
Synonyms: NCI-H2106, NCIH2106
BT286: 0.30
Synonyms: BT286
BT139: 0.30
Synonyms: BT139
DEL: 0.30
Synonyms: DEL
BT231: 0.29
Synonyms: BT231
EM-2: 0.29
Synonyms: EM-2, EM2
BT228: 0.29
Synonyms: BT228
KMS-34: 0.29
Synonyms: KMS-34, KMS34
LCLC-97TM1: 0.29
Synonyms: LCLC-97TM1, LCLC97TM1
BT504: 0.29
Synonyms: BT504
NCI-H1155: 0.29
Synonyms: NCI-H1155, NCIH1155
RS4;11: 0.28
Synonyms: RS4;11, RS4_11, RS4-11, RS411
BT340: 0.28
Synonyms: BT340
EoL-1-cell: 0.27
Synonyms: EoL-1-cell, EOL-1, EOL1
KMS-21BM: 0.27
Synonyms: KMS-21BM, KMS21BM
HT-1376: 0.27
Synonyms: HT-1376, HT1376
BT422: 0.27
Synonyms: BT422
MOLM-13: 0.27
Synonyms: MOLM-13, MOLM13
Hs 822.T: 0.27
Synonyms: Hs 822.T, Hs_822.T, HS822T
BT248: 0.27
Synonyms: BT248
Hs-578-T: 0.26
Synonyms: Hs-578-T, Hs 578T, Hs_578T, HS578T, hs578t
BT12: 0.26
Synonyms: BT12
NCI-H1694: 0.26
Synonyms: NCI-H1694, NCIH1694
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
HCC-95: 0.00
Synonyms: HCC-95, HCC95
WSU-DLCL2: 0.00
Synonyms: WSU-DLCL2, WSUDLCL2
SNU-201: 0.00
Synonyms: SNU-201, SNU201
HSC-3: 0.00
Synonyms: HSC-3, HSC3
HEL: 0.00
Synonyms: HEL
LAMA-84: 0.00
Synonyms: LAMA-84, LAMA84
NCI-H2030: 0.00
Synonyms: NCI-H2030, NCIH2030
NCI-H2228: 0.00
Synonyms: NCI-H2228, NCIH2228
FU-OV-1: 0.00
Synonyms: FU-OV-1, FUOV1
SK-MEL-5: 0.00
Synonyms: SK-MEL-5, SKMEL5
LC-1/sq-SF: 0.00
Synonyms: LC-1/sq-SF, LC1SQSF
GI-1: 0.00
Synonyms: GI-1, GI1
LU-65: 0.00
Synonyms: LU-65, LU65
T98G: 0.00
Synonyms: T98G
TT2609-C02: 0.00
Synonyms: TT2609-C02, TT2609C02
Panc 02.03: 0.00
Synonyms: Panc 02.03, Panc_02.03, PANC-02-03, PANC0203
SNU-475: 0.00
Synonyms: SNU-475, SNU475
Caki-2: 0.00
Synonyms: Caki-2, CAKI2
huH-1: 0.00
Synonyms: huH-1, HUH1
KNS-42: 0.00
Synonyms: KNS-42, KNS42
PE/CA-PJ49: 0.00
Synonyms: PE/CA-PJ49, PE_CA-PJ49, PECAPJ49
NCI-H522: 0.00
Synonyms: NCI-H522, NCIH522
JeKo-1: 0.00
Synonyms: JeKo-1, JEKO-1, JEKO1
IGR-37: 0.00
Synonyms: IGR-37, IGR37
KNS-62: 0.00
Synonyms: KNS-62, KNS62
CAL-33: 0.00
Synonyms: CAL-33, CAL33
HCC-1438: 0.00
Synonyms: HCC-1438, HCC1438
KYSE-30: 0.00
Synonyms: KYSE-30, KYSE30
OCI-AML5: 0.00
Synonyms: OCI-AML5, OCIAML5
NCI-H1651: 0.00
Synonyms: NCI-H1651, NCIH1651
Download SVG
0.00
1.00
2.00
3.00
4.00
5.00
6.00
7.00
8.00
9.00
10.00
11.00
NU-DUL-1
NU-DUL-1
G-402
G-402
HH
HH
RCH-ACV
RCH-ACV
BV-173
BV-173
YAMATO
YAMATO
NCI-H661
NCI-H661
RI-1
RI-1
KALS-1
KALS-1
COLO-678
COLO-678
KMS-18
KMS-18
ONS-76
ONS-76
L-540
L-540
SW1783
SW1783
KASUMI-1
KASUMI-1
OE21
OE21
JURL-MK1
JURL-MK1
RH-30
RH-30
JHH-5
JHH-5
KMS-12-BM
KMS-12-BM
NCI-H211
NCI-H211
P3HR-1
P3HR-1
JM1
JM1
Panc 04.03
Panc 04.03
SCaBER
SCaBER
UM-UC-1
UM-UC-1
NCI-H647
NCI-H647
KASUMI-2
KASUMI-2
PLC-PRF-5
PLC-PRF-5
EKVX
EKVX
Hs 822.T
Hs 822.T
NCI-H1385
NCI-H1385
EoL-1-cell
EoL-1-cell
BT422
BT422
MDA-MB-435
MDA-MB-435
LCLC-97TM1
LCLC-97TM1
P31-FUJ
P31-FUJ
EHEB
EHEB
NCI-H1155
NCI-H1155
BT504
BT504
BT248
BT248
MOLM-13
MOLM-13
EM-2
EM-2
BT228
BT228
DEL
DEL
RS4;11
RS4;11
BT286
BT286
NCI-H2106
NCI-H2106
KMS-34
KMS-34
SKM-1
SKM-1
Hs-578-T
Hs-578-T
AML-193
AML-193
HCC2935
HCC2935
BT139
BT139
BT231
BT231
BT239
BT239
KNS-60
KNS-60
Hs 888.T
Hs 888.T
BT159
BT159
MONO-MAC-1
MONO-MAC-1
NU-DUL-1
G-402
HH
RCH-ACV
BV-173
YAMATO
NCI-H661
RI-1
KALS-1
COLO-678
KMS-18
ONS-76
L-540
SW1783
KASUMI-1
OE21
JURL-MK1
RH-30
JHH-5
KMS-12-BM
NCI-H211
P3HR-1
JM1
Panc 04.03
SCaBER
UM-UC-1
NCI-H647
KASUMI-2
PLC-PRF-5
EKVX
Hs 822.T
NCI-H1385
EoL-1-cell
BT422
MDA-MB-435
LCLC-97TM1
P31-FUJ
EHEB
NCI-H1155
BT504
BT248
MOLM-13
EM-2
BT228
DEL
RS4;11
BT286
NCI-H2106
KMS-34
SKM-1
Hs-578-T
AML-193
HCC2935
BT139
BT231
BT239
KNS-60
Hs 888.T
BT159
MONO-MAC-1
NU-DUL-1: 11.30 (log10 µM)
Synonyms: NU-DUL-1, NUDUL1
G-402: 8.50 (log10 µM)
Synonyms: G-402, G402
HH: 6.65 (log10 µM)
Synonyms: HH
RCH-ACV: 5.83 (log10 µM)
Synonyms: RCH-ACV, RCHACV
BV-173: 5.22 (log10 µM)
Synonyms: BV-173, BV173
YAMATO: 4.75 (log10 µM)
Synonyms: YAMATO
NCI-H661: 4.51 (log10 µM)
Synonyms: NCI-H661, NCIH661
RI-1: 4.18 (log10 µM)
Synonyms: RI-1, RI1
KALS-1: 4.12 (log10 µM)
Synonyms: KALS-1, KALS1
COLO-678: 4.00 (log10 µM)
Synonyms: COLO-678, COLO 678, COLO678
KMS-18: 3.80 (log10 µM)
Synonyms: KMS-18, KMS18
ONS-76: 3.72 (log10 µM)
Synonyms: ONS-76, ONS76
L-540: 3.69 (log10 µM)
Synonyms: L-540, L540
SW1783: 3.68 (log10 µM)
Synonyms: SW1783, SW 1783, SW_1783
KASUMI-1: 3.57 (log10 µM)
Synonyms: KASUMI-1, Kasumi-1, KASUMI1
OE21: 3.53 (log10 µM)
Synonyms: OE21
JURL-MK1: 3.38 (log10 µM)
Synonyms: JURL-MK1, JURLMK1
RH-30: 3.33 (log10 µM)
Synonyms: RH-30, RH30
JHH-5: 3.16 (log10 µM)
Synonyms: JHH-5, JHH5
KMS-12-BM: 3.08 (log10 µM)
Synonyms: KMS-12-BM, KMS12BM
NCI-H211: 3.00 (log10 µM)
Synonyms: NCI-H211, NCIH211
P3HR-1: 2.92 (log10 µM)
Synonyms: P3HR-1, P3HR1
JM1: 2.91 (log10 µM)
Synonyms: JM1
Panc 04.03: 2.82 (log10 µM)
Synonyms: Panc 04.03, Panc_04.03, PANC-04-03, PANC0403
SCaBER: 2.79 (log10 µM)
Synonyms: SCaBER, SCABER
UM-UC-1: 2.76 (log10 µM)
Synonyms: UM-UC-1, UMUC1
NCI-H647: 2.75 (log10 µM)
Synonyms: NCI-H647, NCIH647
KASUMI-2: 2.67 (log10 µM)
Synonyms: KASUMI-2, KASUMI2
PLC-PRF-5: 2.64 (log10 µM)
Synonyms: PLC-PRF-5, PLC/PRF/5, PLC_PRF_5, PLCPRF5
EKVX: 2.63 (log10 µM)
Synonyms: EKVX
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
Hs 822.T: 0.66 (log10 µM)
Synonyms: Hs 822.T, Hs_822.T, HS822T
NCI-H1385: 0.66 (log10 µM)
Synonyms: NCI-H1385, NCIH1385
EoL-1-cell: 0.65 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
BT422: 0.64 (log10 µM)
Synonyms: BT422
MDA-MB-435: 0.64 (log10 µM)
Synonyms: MDA-MB-435, MDA-MB-435S, MDAMB435S
LCLC-97TM1: 0.64 (log10 µM)
Synonyms: LCLC-97TM1, LCLC97TM1
P31-FUJ: 0.63 (log10 µM)
Synonyms: P31-FUJ, P31/FUJ, P31_FUJ, P31FUJ
EHEB: 0.63 (log10 µM)
Synonyms: EHEB
NCI-H1155: 0.62 (log10 µM)
Synonyms: NCI-H1155, NCIH1155
BT504: 0.61 (log10 µM)
Synonyms: BT504
BT248: 0.61 (log10 µM)
Synonyms: BT248
MOLM-13: 0.60 (log10 µM)
Synonyms: MOLM-13, MOLM13
EM-2: 0.59 (log10 µM)
Synonyms: EM-2, EM2
BT228: 0.58 (log10 µM)
Synonyms: BT228
DEL: 0.58 (log10 µM)
Synonyms: DEL
RS4;11: 0.58 (log10 µM)
Synonyms: RS4;11, RS4_11, RS4-11, RS411
BT286: 0.58 (log10 µM)
Synonyms: BT286
NCI-H2106: 0.58 (log10 µM)
Synonyms: NCI-H2106, NCIH2106
KMS-34: 0.58 (log10 µM)
Synonyms: KMS-34, KMS34
SKM-1: 0.58 (log10 µM)
Synonyms: SKM-1, SKM1
Hs-578-T: 0.57 (log10 µM)
Synonyms: Hs-578-T, Hs 578T, Hs_578T, HS578T, hs578t
AML-193: 0.57 (log10 µM)
Synonyms: AML-193, AML193
HCC2935: 0.56 (log10 µM)
Synonyms: HCC2935
BT139: 0.54 (log10 µM)
Synonyms: BT139
BT231: 0.54 (log10 µM)
Synonyms: BT231
BT239: 0.46 (log10 µM)
Synonyms: BT239
KNS-60: 0.45 (log10 µM)
Synonyms: KNS-60, KNS60
Hs 888.T: 0.40 (log10 µM)
Synonyms: Hs 888.T, Hs_888.T, HS888T
BT159: 0.11 (log10 µM)
Synonyms: BT159
MONO-MAC-1: 0.09 (log10 µM)
Synonyms: MONO-MAC-1, MONOMAC1
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
BRD-K71935468: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
autonomic_ganglia
autonomic_ganglia
biliary_tract
biliary_tract
oesophagus
oesophagus
urinary_tract
urinary_tract
cervix
cervix
pleura
pleura
central_nervous_system
central_nervous_system
liver
liver
upper_aerodigestive_tract
upper_aerodigestive_tract
pancreas
pancreas
endometrium
endometrium
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
lung
lung
ovary
ovary
thyroid
thyroid
large_intestine
large_intestine
kidney
kidney
bone
bone
stomach
stomach
breast
breast
skin
skin
soft_tissue
soft_tissue
prostate
prostate
unknown
unknown
0.00
0.50
1.00
1.50
2.00
2.50
3.00
3.50
4.00
cervix
cervix
unknown
unknown
ovary
ovary
thyroid
thyroid
skin
skin
breast
breast
pancreas
pancreas
prostate
prostate
lung
lung
kidney
kidney
stomach
stomach
soft_tissue
soft_tissue
endometrium
endometrium
large_intestine
large_intestine
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
bone
bone
upper_aerodigestive_tract
upper_aerodigestive_tract
biliary_tract
biliary_tract
liver
liver
central_nervous_system
central_nervous_system
urinary_tract
urinary_tract
pleura
pleura
oesophagus
oesophagus
autonomic_ganglia
autonomic_ganglia
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to BRD-K71935468
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
RFPL4A
CTRPv2
pan-cancer
AAC
0.096
0.01
mRNA
STARD10
CTRPv2
pan-cancer
AAC
0.11
0.01
mRNA
ZNF346
CTRPv2
pan-cancer
AAC
-0.1
0.01
mRNA
WNT6
CTRPv2
pan-cancer
AAC
0.094
0.01
mRNA
HECW1
CTRPv2
pan-cancer
AAC
-0.099
0.01
mRNA
NEK11
CTRPv2
pan-cancer
AAC
0.1
0.01
mRNA
SORL1
CTRPv2
pan-cancer
AAC
-0.098
0.01
mRNA
IQSEC1
CTRPv2
pan-cancer
AAC
0.098
0.01
mRNA
U2AF1L4
CTRPv2
pan-cancer
AAC
0.1
0.01
mRNA
FARP2
CTRPv2
pan-cancer
AAC
-0.11
0.01
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