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neratinib

Synonyms

SourcesNames Used
CTRPv2neratinib
PharmacoGx neratinib

External IDs

DatabaseIdentifier
Smiles: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
Inchikey: JWNPDZNEKVCWMY-VQHVLOKHSA-N
Pubchem: 9915743

Annotated Targets

EGFR, ERBB2, KDR

FDA Approval Status

Approved
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Top molecular features associated with response to neratinib


Feature TypeStandardized
Nominal ANOVA
mRNA CYP2J2 CTRPv2 pan-cancer AAC 0.18 4e-06
mRNA TFE3 CTRPv2 pan-cancer AAC -0.18 4e-06
mRNA PIP4K2B CTRPv2 pan-cancer AAC 0.16 4e-06
mRNA JUP CTRPv2 pan-cancer AAC 0.18 4e-06
mRNA ESRP2 CTRPv2 pan-cancer AAC 0.2 5e-06
mRNA MISP CTRPv2 pan-cancer AAC 0.2 5e-06
mRNA TULP3 CTRPv2 pan-cancer AAC -0.17 5e-06
mRNA ERRFI1 CTRPv2 pan-cancer AAC -0.17 5e-06
mRNA THAP3 CTRPv2 pan-cancer AAC -0.16 5e-06
mRNA SPDEF CTRPv2 pan-cancer AAC 0.2 6e-06
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