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EX-527

EX-527

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	EX-527
PharmacoGx	EX-527

External IDs

Database	Identifier
Smiles:	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
Inchikey:	FUZYTVDVLBBXDL-UHFFFAOYSA-N
Pubchem:	5113032

Annotated Targets

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to EX-527

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TACR1	GDSC1000	pan-cancer	AAC	0.12	0.0005
mRNA	C2orf40	GDSC1000	pan-cancer	AAC	0.12	0.0005
mRNA	PROX1	CTRPv2	pan-cancer	AAC	0.14	0.0005
mRNA	ONECUT2	CTRPv2	pan-cancer	AAC	0.14	0.0005
mRNA	HIST1H4G	CTRPv2	pan-cancer	AAC	0.13	0.0005
mRNA	ARHGEF2	GDSC1000	pan-cancer	AAC	-0.13	0.0005
mRNA	CFAP61	CTRPv2	pan-cancer	AAC	0.13	0.0005
mRNA	STOX2	CTRPv2	pan-cancer	AAC	0.17	0.0005
mRNA	SVOP	CTRPv2	pan-cancer	AAC	0.14	0.0005
mRNA	SUMO3	CTRPv2	pan-cancer	AAC	-0.14	0.0005

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