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AZD-7545

AZD-7545

Synonyms

Sources	Names Used
CTRPv2	AZD7545
PharmacoGx	AZD-7545

External IDs

Database	Identifier
Smiles:	CC(C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O
Inchikey:	DTDZLJHKVNTQGZ-GOSISDBHSA-N
Pubchem:	16741245

Annotated Targets

PDK1, PDK2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AZD-7545

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ARHGAP11A	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	CEP295NL	CTRPv2	pan-cancer	AAC	-0.17	0.0001
mRNA	PPDPF	CTRPv2	pan-cancer	AAC	-0.17	0.0001
mRNA	WDR3	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	ADNP2	CTRPv2	pan-cancer	AAC	0.15	0.0001
mRNA	CTD-2587H24.4	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	LRRC70	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	TIPIN	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	UTP15	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	RASGEF1C	CTRPv2	pan-cancer	AAC	0.14	0.0001

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