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AZD-7545
AZD-7545
Synonyms
Sources
Names Used
CTRPv2
AZD7545
PharmacoGx
AZD-7545
External IDs
Database
Identifier
Smiles:
CC(C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O
Inchikey:
DTDZLJHKVNTQGZ-GOSISDBHSA-N
Pubchem:
16741245
Annotated Targets
PDK1
,
PDK2
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with AZD-7545
(per dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
829
Download SVG
Number of tissues tested with AZD-7545
(per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
AZD-7545: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
SW1573
SW1573
CAL-78
CAL-78
PEER
PEER
NCI-H1573
NCI-H1573
HEC-265
HEC-265
SK-MM-2
SK-MM-2
UM-UC-3
UM-UC-3
HCC-1195
HCC-1195
TYK-nu
TYK-nu
EoL-1-cell
EoL-1-cell
U-2-OS
U-2-OS
RKO
RKO
EFM-192A
EFM-192A
HUH-6-clone5
HUH-6-clone5
SBC-5
SBC-5
HEC-50B
HEC-50B
MONO-MAC-6
MONO-MAC-6
RKN
RKN
KMS-34
KMS-34
HSC-4
HSC-4
HSC-2
HSC-2
KMS-12-BM
KMS-12-BM
GB-1
GB-1
DEL
DEL
SW620
SW620
U-937
U-937
HEC-6
HEC-6
ACC-MESO-1
ACC-MESO-1
HEC-251
HEC-251
KU-19-19
KU-19-19
NMC-G1
NMC-G1
BT112
BT112
OS-RC-2
OS-RC-2
BT164
BT164
KNS81
KNS81
NCI-H1693
NCI-H1693
SNU-475
SNU-475
CAL-33
CAL-33
NCI-H1435
NCI-H1435
IA-LM
IA-LM
A101D
A101D
COLO-800
COLO-800
SNU-387
SNU-387
SNU-201
SNU-201
Capan-2
Capan-2
CAS-1
CAS-1
RERF-LC-Ad1
RERF-LC-Ad1
PA-TU-8902
PA-TU-8902
BT179
BT179
LS-1034
LS-1034
DK-MG
DK-MG
A2058
A2058
LUDLU-1
LUDLU-1
PE/CA-PJ41 (clone D2)
PE/CA-PJ41 (clone D2)
PE/CA-PJ15
PE/CA-PJ15
SW948
SW948
OVCAR-5
OVCAR-5
Calu-1
Calu-1
HCC-1438
HCC-1438
KG-1-C
KG-1-C
SW1573
CAL-78
PEER
NCI-H1573
HEC-265
SK-MM-2
UM-UC-3
HCC-1195
TYK-nu
EoL-1-cell
U-2-OS
RKO
EFM-192A
HUH-6-clone5
SBC-5
HEC-50B
MONO-MAC-6
RKN
KMS-34
HSC-4
HSC-2
KMS-12-BM
GB-1
DEL
SW620
U-937
HEC-6
ACC-MESO-1
HEC-251
KU-19-19
NMC-G1
BT112
OS-RC-2
BT164
KNS81
NCI-H1693
SNU-475
CAL-33
NCI-H1435
IA-LM
A101D
COLO-800
SNU-387
SNU-201
Capan-2
CAS-1
RERF-LC-Ad1
PA-TU-8902
BT179
LS-1034
DK-MG
A2058
LUDLU-1
PE/CA-PJ41 (clone D2)
PE/CA-PJ15
SW948
OVCAR-5
Calu-1
HCC-1438
KG-1-C
SW1573: 0.41
Synonyms: SW1573, SW 1573, SW_1573
CAL-78: 0.32
Synonyms: CAL-78, CAL78
PEER: 0.32
Synonyms: PEER
NCI-H1573: 0.28
Synonyms: NCI-H1573, NCIH1573
HEC-265: 0.28
Synonyms: HEC-265, HEC265
SK-MM-2: 0.27
Synonyms: SK-MM-2, SKMM2
UM-UC-3: 0.27
Synonyms: UM-UC-3, UMUC3
HCC-1195: 0.27
Synonyms: HCC-1195, HCC1195
TYK-nu: 0.27
Synonyms: TYK-nu, TYKNU
EoL-1-cell: 0.27
Synonyms: EoL-1-cell, EOL-1, EOL1
U-2-OS: 0.26
Synonyms: U-2-OS, U-2 OS, U-2_OS, U2OS
RKO: 0.26
Synonyms: RKO
EFM-192A: 0.25
Synonyms: EFM-192A, EFM192A, efm192a
HUH-6-clone5: 0.25
Synonyms: HUH-6-clone5, HuH-6, HUH6
SBC-5: 0.24
Synonyms: SBC-5, SBC5
HEC-50B: 0.24
Synonyms: HEC-50B, HEC50B
MONO-MAC-6: 0.24
Synonyms: MONO-MAC-6, MONOMAC6
RKN: 0.24
Synonyms: RKN
KMS-34: 0.24
Synonyms: KMS-34, KMS34
HSC-4: 0.24
Synonyms: HSC-4, HSC4
HSC-2: 0.24
Synonyms: HSC-2, HSC2
KMS-12-BM: 0.24
Synonyms: KMS-12-BM, KMS12BM
GB-1: 0.24
Synonyms: GB-1, GB1
DEL: 0.24
Synonyms: DEL
SW620: 0.23
Synonyms: SW620, SW 620
U-937: 0.23
Synonyms: U-937, U937
HEC-6: 0.23
Synonyms: HEC-6, HEC6
ACC-MESO-1: 0.23
Synonyms: ACC-MESO-1, ACCMESO1
HEC-251: 0.23
Synonyms: HEC-251, HEC251
KU-19-19: 0.23
Synonyms: KU-19-19, KU1919
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
NMC-G1: 0.00
Synonyms: NMC-G1, NMCG1
BT112: 0.00
Synonyms: BT112
OS-RC-2: 0.00
Synonyms: OS-RC-2, OSRC2
BT164: 0.00
Synonyms: BT164
KNS81: 0.00
Synonyms: KNS81
NCI-H1693: 0.00
Synonyms: NCI-H1693, NCIH1693
SNU-475: 0.00
Synonyms: SNU-475, SNU475
CAL-33: 0.00
Synonyms: CAL-33, CAL33
NCI-H1435: 0.00
Synonyms: NCI-H1435, NCIH1435
IA-LM: 0.00
Synonyms: IA-LM, IALM
A101D: 0.00
Synonyms: A101D
COLO-800: 0.00
Synonyms: COLO-800, COLO 800, COLO800
SNU-387: 0.00
Synonyms: SNU-387, SNU387
SNU-201: 0.00
Synonyms: SNU-201, SNU201
Capan-2: 0.00
Synonyms: Capan-2, CAPAN2
CAS-1: 0.00
Synonyms: CAS-1, CAS1
RERF-LC-Ad1: 0.00
Synonyms: RERF-LC-Ad1, RERFLCAD1
PA-TU-8902: 0.00
Synonyms: PA-TU-8902, PATU8902
BT179: 0.00
Synonyms: BT179
LS-1034: 0.00
Synonyms: LS-1034, LS1034
DK-MG: 0.00
Synonyms: DK-MG, DKMG
A2058: 0.00
Synonyms: A2058
LUDLU-1: 0.00
Synonyms: LUDLU-1, LUDLU1
PE/CA-PJ41 (clone D2): 0.00
Synonyms: PE/CA-PJ41 (clone D2), PE_CA-PJ41__clone_D2_, PECAPJ41CLONED2
PE/CA-PJ15: 0.00
Synonyms: PE/CA-PJ15, PE_CA-PJ15, PE-CA-PJ15, PECAPJ15
SW948: 0.00
Synonyms: SW948, SW 948
OVCAR-5: 0.00
Synonyms: OVCAR-5, OVCAR5
Calu-1: 0.00
Synonyms: Calu-1, CALU1
HCC-1438: 0.00
Synonyms: HCC-1438, HCC1438
KG-1-C: 0.00
Synonyms: KG-1-C, KG1C
Download SVG
0.00
1.00
2.00
3.00
4.00
5.00
6.00
7.00
8.00
9.00
10.00
11.00
12.00
IM-95
IM-95
MDA-MB-231
MDA-MB-231
SNU-213
SNU-213
Panc 04.03
Panc 04.03
SW1783
SW1783
SNU-46
SNU-46
GAMG
GAMG
TC-71
TC-71
SNU-1033
SNU-1033
2004
2004
NCI-H1563
NCI-H1563
BT440
BT440
FU-OV-1
FU-OV-1
PE/CA-PJ49
PE/CA-PJ49
MEL-JUSO
MEL-JUSO
U-118-MG
U-118-MG
BT159
BT159
TE-14
TE-14
SK-N-SH
SK-N-SH
639-V
639-V
CAPAN-1
CAPAN-1
COR-L105
COR-L105
TE-4
TE-4
SNU-1076
SNU-1076
T-24
T-24
SCC-9
SCC-9
YD-8
YD-8
SNU-840
SNU-840
BT216
BT216
SCC-25
SCC-25
Daoy
Daoy
HCC-1195
HCC-1195
AGS
AGS
SKM-1
SKM-1
SF126
SF126
MCAS
MCAS
HEC-6
HEC-6
ACC-MESO-1
ACC-MESO-1
HSC-2
HSC-2
GB-1
GB-1
RPMI-8402
RPMI-8402
HSC-4
HSC-4
SW620
SW620
HEC-251
HEC-251
RERF-LC-AI
RERF-LC-AI
MOLM-16
MOLM-16
KMS-21BM
KMS-21BM
DEL
DEL
SBC-5
SBC-5
FU97
FU97
VM-CUB-1
VM-CUB-1
HEC-50B
HEC-50B
RKN
RKN
TYK-nu
TYK-nu
UM-UC-3
UM-UC-3
RKO
RKO
HEC-265
HEC-265
EoL-1-cell
EoL-1-cell
ALL-SIL
ALL-SIL
PEER
PEER
IM-95
MDA-MB-231
SNU-213
Panc 04.03
SW1783
SNU-46
GAMG
TC-71
SNU-1033
2004
NCI-H1563
BT440
FU-OV-1
PE/CA-PJ49
MEL-JUSO
U-118-MG
BT159
TE-14
SK-N-SH
639-V
CAPAN-1
COR-L105
TE-4
SNU-1076
T-24
SCC-9
YD-8
SNU-840
BT216
SCC-25
Daoy
HCC-1195
AGS
SKM-1
SF126
MCAS
HEC-6
ACC-MESO-1
HSC-2
GB-1
RPMI-8402
HSC-4
SW620
HEC-251
RERF-LC-AI
MOLM-16
KMS-21BM
DEL
SBC-5
FU97
VM-CUB-1
HEC-50B
RKN
TYK-nu
UM-UC-3
RKO
HEC-265
EoL-1-cell
ALL-SIL
PEER
IM-95: 12.42 (log10 µM)
Synonyms: IM-95, IM95
MDA-MB-231: 11.95 (log10 µM)
Synonyms: MDA-MB-231, MDAMB231, mdamb231
SNU-213: 9.96 (log10 µM)
Synonyms: SNU-213, SNU213
Panc 04.03: 9.67 (log10 µM)
Synonyms: Panc 04.03, Panc_04.03, PANC-04-03, PANC0403
SW1783: 8.08 (log10 µM)
Synonyms: SW1783, SW 1783, SW_1783
SNU-46: 6.87 (log10 µM)
Synonyms: SNU-46, SNU46
GAMG: 6.36 (log10 µM)
Synonyms: GAMG
TC-71: 6.00 (log10 µM)
Synonyms: TC-71, TC71
SNU-1033: 5.57 (log10 µM)
Synonyms: SNU-1033, SNU1033
2004: 5.51 (log10 µM)
Synonyms: 2004
NCI-H1563: 5.46 (log10 µM)
Synonyms: NCI-H1563, NCIH1563
BT440: 5.38 (log10 µM)
Synonyms: BT440
FU-OV-1: 5.34 (log10 µM)
Synonyms: FU-OV-1, FUOV1
PE/CA-PJ49: 5.13 (log10 µM)
Synonyms: PE/CA-PJ49, PE_CA-PJ49, PECAPJ49
MEL-JUSO: 4.74 (log10 µM)
Synonyms: MEL-JUSO, MELJUSO
U-118-MG: 4.63 (log10 µM)
Synonyms: U-118-MG, U-118 MG, U-118_MG, U118MG
BT159: 4.61 (log10 µM)
Synonyms: BT159
TE-14: 4.47 (log10 µM)
Synonyms: TE-14, TE14
SK-N-SH: 4.39 (log10 µM)
Synonyms: SK-N-SH, SKNSH
639-V: 4.27 (log10 µM)
Synonyms: 639-V, 639V
CAPAN-1: 3.96 (log10 µM)
Synonyms: CAPAN-1, Capan-1, CAPAN1
COR-L105: 3.80 (log10 µM)
Synonyms: COR-L105, CORL105
TE-4: 3.76 (log10 µM)
Synonyms: TE-4, TE4
SNU-1076: 3.72 (log10 µM)
Synonyms: SNU-1076, SNU1076
T-24: 3.57 (log10 µM)
Synonyms: T-24, T24
SCC-9: 3.57 (log10 µM)
Synonyms: SCC-9, SCC9
YD-8: 3.52 (log10 µM)
Synonyms: YD-8, YD8
SNU-840: 3.45 (log10 µM)
Synonyms: SNU-840, SNU840
BT216: 3.44 (log10 µM)
Synonyms: BT216
SCC-25: 3.36 (log10 µM)
Synonyms: SCC-25, SCC25
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
Daoy: 0.81 (log10 µM)
Synonyms: Daoy, DAOY
HCC-1195: 0.81 (log10 µM)
Synonyms: HCC-1195, HCC1195
AGS: 0.81 (log10 µM)
Synonyms: AGS
SKM-1: 0.80 (log10 µM)
Synonyms: SKM-1, SKM1
SF126: 0.80 (log10 µM)
Synonyms: SF126
MCAS: 0.80 (log10 µM)
Synonyms: MCAS
HEC-6: 0.80 (log10 µM)
Synonyms: HEC-6, HEC6
ACC-MESO-1: 0.80 (log10 µM)
Synonyms: ACC-MESO-1, ACCMESO1
HSC-2: 0.78 (log10 µM)
Synonyms: HSC-2, HSC2
GB-1: 0.78 (log10 µM)
Synonyms: GB-1, GB1
RPMI-8402: 0.78 (log10 µM)
Synonyms: RPMI-8402, RPMI8402
HSC-4: 0.78 (log10 µM)
Synonyms: HSC-4, HSC4
SW620: 0.78 (log10 µM)
Synonyms: SW620, SW 620
HEC-251: 0.77 (log10 µM)
Synonyms: HEC-251, HEC251
RERF-LC-AI: 0.77 (log10 µM)
Synonyms: RERF-LC-AI, RERFLCAI
MOLM-16: 0.77 (log10 µM)
Synonyms: MOLM-16, MOLM16
KMS-21BM: 0.76 (log10 µM)
Synonyms: KMS-21BM, KMS21BM
DEL: 0.74 (log10 µM)
Synonyms: DEL
SBC-5: 0.74 (log10 µM)
Synonyms: SBC-5, SBC5
FU97: 0.74 (log10 µM)
Synonyms: FU97
VM-CUB-1: 0.73 (log10 µM)
Synonyms: VM-CUB-1, VM-CUB1, VMCUB1
HEC-50B: 0.67 (log10 µM)
Synonyms: HEC-50B, HEC50B
RKN: 0.67 (log10 µM)
Synonyms: RKN
TYK-nu: 0.64 (log10 µM)
Synonyms: TYK-nu, TYKNU
UM-UC-3: 0.62 (log10 µM)
Synonyms: UM-UC-3, UMUC3
RKO: 0.60 (log10 µM)
Synonyms: RKO
HEC-265: 0.58 (log10 µM)
Synonyms: HEC-265, HEC265
EoL-1-cell: 0.55 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
ALL-SIL: 0.55 (log10 µM)
Synonyms: ALL-SIL, ALLSIL
PEER: 0.41 (log10 µM)
Synonyms: PEER
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
AZD-7545: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
salivary_gland
salivary_gland
unknown
unknown
upper_aerodigestive_tract
upper_aerodigestive_tract
central_nervous_system
central_nervous_system
pancreas
pancreas
autonomic_ganglia
autonomic_ganglia
kidney
kidney
prostate
prostate
skin
skin
large_intestine
large_intestine
oesophagus
oesophagus
lung
lung
stomach
stomach
thyroid
thyroid
breast
breast
ovary
ovary
bone
bone
liver
liver
biliary_tract
biliary_tract
endometrium
endometrium
soft_tissue
soft_tissue
pleura
pleura
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
urinary_tract
urinary_tract
cervix
cervix
0.00
0.50
1.00
1.50
2.00
2.50
3.00
3.50
4.00
cervix
cervix
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
biliary_tract
biliary_tract
endometrium
endometrium
urinary_tract
urinary_tract
bone
bone
liver
liver
soft_tissue
soft_tissue
central_nervous_system
central_nervous_system
stomach
stomach
pleura
pleura
ovary
ovary
lung
lung
large_intestine
large_intestine
upper_aerodigestive_tract
upper_aerodigestive_tract
oesophagus
oesophagus
thyroid
thyroid
autonomic_ganglia
autonomic_ganglia
breast
breast
skin
skin
prostate
prostate
salivary_gland
salivary_gland
kidney
kidney
pancreas
pancreas
unknown
unknown
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to AZD-7545
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
DNTTIP2
CTRPv2
pan-cancer
AAC
0.081
0.03
mRNA
F2RL2
CTRPv2
pan-cancer
AAC
-0.082
0.03
mRNA
NRBP2
CTRPv2
pan-cancer
AAC
-0.087
0.03
mRNA
ATP8B4
CTRPv2
pan-cancer
AAC
0.083
0.03
mRNA
DRAM1
CTRPv2
pan-cancer
AAC
-0.1
0.03
mRNA
CIR1
CTRPv2
pan-cancer
AAC
-0.081
0.03
mRNA
NR1H2
CTRPv2
pan-cancer
AAC
-0.083
0.03
mRNA
NHLRC1
CTRPv2
pan-cancer
AAC
-0.086
0.03
mRNA
UNC5CL
CTRPv2
pan-cancer
AAC
0.081
0.03
mRNA
RBM43
CTRPv2
pan-cancer
AAC
-0.084
0.03
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