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AZD-7545

AZD-7545

Synonyms

Sources	Names Used
CTRPv2	AZD7545
PharmacoGx	AZD-7545

External IDs

Database	Identifier
Smiles:	CC(C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O
Inchikey:	DTDZLJHKVNTQGZ-GOSISDBHSA-N
Pubchem:	16741245

Annotated Targets

PDK1, PDK2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AZD-7545

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CD93	CTRPv2	pan-cancer	AAC	0.13	0.0003
mRNA	LACC1	CTRPv2	pan-cancer	AAC	-0.13	0.0003
mRNA	XRCC2	CTRPv2	pan-cancer	AAC	0.14	0.0003
mRNA	PAX5	CTRPv2	pan-cancer	AAC	-0.14	0.0003
mRNA	DHX33	CTRPv2	pan-cancer	AAC	0.14	0.0003
mRNA	GTF2IRD2	CTRPv2	pan-cancer	AAC	-0.13	0.0003
mRNA	POLRMT	CTRPv2	pan-cancer	AAC	0.14	0.0003
mRNA	GIPC1	CTRPv2	pan-cancer	AAC	-0.16	0.0004
mRNA	RFC5	CTRPv2	pan-cancer	AAC	0.13	0.0004
mRNA	PEA15	CTRPv2	pan-cancer	AAC	-0.15	0.0004

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