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AZD-7545

AZD-7545

Synonyms

Sources	Names Used
CTRPv2	AZD7545
PharmacoGx	AZD-7545

External IDs

Database	Identifier
Smiles:	CC(C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O
Inchikey:	DTDZLJHKVNTQGZ-GOSISDBHSA-N
Pubchem:	16741245

Annotated Targets

PDK1, PDK2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AZD-7545

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TMEM200C	CTRPv2	pan-cancer	AAC	0.12	0.001
mRNA	GDAP2	CTRPv2	pan-cancer	AAC	0.12	0.001
mRNA	SMYD4	CTRPv2	pan-cancer	AAC	0.12	0.001
mRNA	NALCN	CTRPv2	pan-cancer	AAC	-0.12	0.001
mRNA	AK6	CTRPv2	pan-cancer	AAC	0.12	0.001
mRNA	COL6A1	CTRPv2	pan-cancer	AAC	-0.13	0.001
mRNA	HAUS7	CTRPv2	pan-cancer	AAC	0.12	0.001
mRNA	CCDC34	CTRPv2	pan-cancer	AAC	0.12	0.001
mRNA	DYNC1I2	CTRPv2	pan-cancer	AAC	-0.13	0.001
mRNA	EXOSC5	CTRPv2	pan-cancer	AAC	0.13	0.001

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