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SKI-II
SKI-II
Synonyms
Sources
Names Used
CTRPv2
SKI-II
PharmacoGx
SKI-II
External IDs
Database
Identifier
Smiles:
C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
Inchikey:
ZFGXZJKLOFCECI-UHFFFAOYSA-N
Pubchem:
753704
Annotated Targets
SPHK1
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with SKI-II (per
dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
805
Download SVG
Number of tissues tested with SKI-II (per
dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
SKI-II: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
BT416
BT416
CHP-126
CHP-126
EoL-1-cell
EoL-1-cell
DMS-79
DMS-79
BT172
BT172
NALM-6
NALM-6
BT422
BT422
SNU-182
SNU-182
GA-10
GA-10
Daudi
Daudi
PLC-PRF-5
PLC-PRF-5
OCI-M1
OCI-M1
NCI-H1341
NCI-H1341
PEER
PEER
MHH-CALL-4
MHH-CALL-4
ST486
ST486
MOLP-8
MOLP-8
BT164
BT164
TALL-1
TALL-1
RPMI-8402
RPMI-8402
SKM-1
SKM-1
OCI-LY3
OCI-LY3
A673
A673
Pfeiffer
Pfeiffer
AU565
AU565
KE-37
KE-37
SUP-T11
SUP-T11
P31-FUJ
P31-FUJ
SU.86.86
SU.86.86
NCI-H2141
NCI-H2141
JMSU-1
JMSU-1
SW1710
SW1710
JIMT-1
JIMT-1
BCPAP
BCPAP
CGTH-W-1
CGTH-W-1
COLO-680N
COLO-680N
ECC12
ECC12
SNU-1196
SNU-1196
SNU-8
SNU-8
HARA
HARA
LU-99A
LU-99A
DLD-1
DLD-1
SNU-620
SNU-620
MKN45
MKN45
SBC-5
SBC-5
KMS-27
KMS-27
NCI-H1838
NCI-H1838
SNU-668
SNU-668
SNU-899
SNU-899
TE-9
TE-9
YD-38
YD-38
NCI-H2444
NCI-H2444
MCAS
MCAS
SK-MEL-28
SK-MEL-28
MDA-MB-435
MDA-MB-435
OE33
OE33
SH-4
SH-4
SK-MEL-2
SK-MEL-2
HCC1419
HCC1419
SK-MEL-3
SK-MEL-3
BT416
CHP-126
EoL-1-cell
DMS-79
BT172
NALM-6
BT422
SNU-182
GA-10
Daudi
PLC-PRF-5
OCI-M1
NCI-H1341
PEER
MHH-CALL-4
ST486
MOLP-8
BT164
TALL-1
RPMI-8402
SKM-1
OCI-LY3
A673
Pfeiffer
AU565
KE-37
SUP-T11
P31-FUJ
SU.86.86
NCI-H2141
JMSU-1
SW1710
JIMT-1
BCPAP
CGTH-W-1
COLO-680N
ECC12
SNU-1196
SNU-8
HARA
LU-99A
DLD-1
SNU-620
MKN45
SBC-5
KMS-27
NCI-H1838
SNU-668
SNU-899
TE-9
YD-38
NCI-H2444
MCAS
SK-MEL-28
MDA-MB-435
OE33
SH-4
SK-MEL-2
HCC1419
SK-MEL-3
BT416: 0.32
Synonyms: BT416
CHP-126: 0.26
Synonyms: CHP-126, CHP126
EoL-1-cell: 0.24
Synonyms: EoL-1-cell, EOL-1, EOL1
DMS-79: 0.24
Synonyms: DMS-79, DMS 79, DMS_79, DMS79
BT172: 0.24
Synonyms: BT172
NALM-6: 0.22
Synonyms: NALM-6, NALM6
BT422: 0.22
Synonyms: BT422
SNU-182: 0.21
Synonyms: SNU-182, SNU182
GA-10: 0.21
Synonyms: GA-10, GA10
Daudi: 0.21
Synonyms: Daudi, DAUDI
PLC-PRF-5: 0.20
Synonyms: PLC-PRF-5, PLC/PRF/5, PLC_PRF_5, PLCPRF5
OCI-M1: 0.20
Synonyms: OCI-M1, OCIM1
NCI-H1341: 0.19
Synonyms: NCI-H1341, NCIH1341
PEER: 0.19
Synonyms: PEER
MHH-CALL-4: 0.19
Synonyms: MHH-CALL-4, MHHCALL4
ST486: 0.18
Synonyms: ST486
MOLP-8: 0.18
Synonyms: MOLP-8, MOLP8
BT164: 0.17
Synonyms: BT164
TALL-1: 0.17
Synonyms: TALL-1, TALL1
RPMI-8402: 0.17
Synonyms: RPMI-8402, RPMI8402
SKM-1: 0.17
Synonyms: SKM-1, SKM1
OCI-LY3: 0.17
Synonyms: OCI-LY3, OCI-LY-3, OCILY3
A673: 0.17
Synonyms: A673, A-673
Pfeiffer: 0.16
Synonyms: Pfeiffer, PFEIFFER
AU565: 0.16
Synonyms: AU565, au565
KE-37: 0.16
Synonyms: KE-37, KE37
SUP-T11: 0.16
Synonyms: SUP-T11, SUPT11
P31-FUJ: 0.16
Synonyms: P31-FUJ, P31/FUJ, P31_FUJ, P31FUJ
SU.86.86: 0.16
Synonyms: SU.86.86, SU8686
NCI-H2141: 0.16
Synonyms: NCI-H2141, NCIH2141
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
JMSU-1: 0.00
Synonyms: JMSU-1, JMSU1
SW1710: 0.00
Synonyms: SW1710, SW-1710
JIMT-1: 0.00
Synonyms: JIMT-1, JIMT1, jimt1
BCPAP: 0.00
Synonyms: BCPAP, B-CPAP
CGTH-W-1: 0.00
Synonyms: CGTH-W-1, CGTHW1
COLO-680N: 0.00
Synonyms: COLO-680N, COLO 680N, COLO680N
ECC12: 0.00
Synonyms: ECC12
SNU-1196: 0.00
Synonyms: SNU-1196, SNU1196
SNU-8: 0.00
Synonyms: SNU-8, SNU8
HARA: 0.00
Synonyms: HARA
LU-99A: 0.00
Synonyms: LU-99A, LU99
DLD-1: 0.00
Synonyms: DLD-1, DLD1
SNU-620: 0.00
Synonyms: SNU-620, SNU620
MKN45: 0.00
Synonyms: MKN45, MKN-45
SBC-5: 0.00
Synonyms: SBC-5, SBC5
KMS-27: 0.00
Synonyms: KMS-27, KMS27
NCI-H1838: 0.00
Synonyms: NCI-H1838, NCIH1838
SNU-668: 0.00
Synonyms: SNU-668, SNU668
SNU-899: 0.00
Synonyms: SNU-899, SNU899
TE-9: 0.00
Synonyms: TE-9, TE9
YD-38: 0.00
Synonyms: YD-38, YD38
NCI-H2444: 0.00
Synonyms: NCI-H2444, NCIH2444
MCAS: 0.00
Synonyms: MCAS
SK-MEL-28: 0.00
Synonyms: SK-MEL-28, SKMEL28
MDA-MB-435: 0.00
Synonyms: MDA-MB-435, MDA-MB-435S, MDAMB435S
OE33: 0.00
Synonyms: OE33
SH-4: 0.00
Synonyms: SH-4, SH4
SK-MEL-2: 0.00
Synonyms: SK-MEL-2, SKMEL2
HCC1419: 0.00
Synonyms: HCC1419, hcc1419
SK-MEL-3: 0.00
Synonyms: SK-MEL-3, SKMEL3
Download SVG
0.00
2.00
4.00
6.00
8.00
10.00
12.00
14.00
16.00
JHOC-5
JHOC-5
LOU-NH91
LOU-NH91
COLO-829
COLO-829
5637
5637
NCI-N87
NCI-N87
DU-4475
DU-4475
NCI-H1563
NCI-H1563
JL-1
JL-1
T3M-10
T3M-10
SNU-449
SNU-449
SW 1353
SW 1353
C2BBe1
C2BBe1
Panc 02.03
Panc 02.03
HDLM-2
HDLM-2
SNU-1105
SNU-1105
BT320
BT320
TE-14
TE-14
BxPC-3
BxPC-3
Panc 04.03
Panc 04.03
GAMG
GAMG
KP-2
KP-2
LC-1/sq-SF
LC-1/sq-SF
ZR-75-30
ZR-75-30
KYSE-70
KYSE-70
SW48
SW48
RL95-2
RL95-2
NCI-H2342
NCI-H2342
OVCAR-4
OVCAR-4
NCI-H2085
NCI-H2085
253J-BV
253J-BV
Pfeiffer
Pfeiffer
KASUMI-1
KASUMI-1
BT112
BT112
SK-MM-2
SK-MM-2
MEC-1
MEC-1
JURKAT
JURKAT
OCI-LY3
OCI-LY3
JM1
JM1
P12-ICHIKAWA
P12-ICHIKAWA
NCI-H2141
NCI-H2141
MOLT-13
MOLT-13
P31-FUJ
P31-FUJ
IMR-32
IMR-32
KE-37
KE-37
RPMI-8402
RPMI-8402
A673
A673
BT164
BT164
MOLP-8
MOLP-8
D-283MED
D-283MED
ST486
ST486
PEER
PEER
SUP-T11
SUP-T11
Daudi
Daudi
OCI-M1
OCI-M1
SKM-1
SKM-1
NCI-H1341
NCI-H1341
MHH-CALL-4
MHH-CALL-4
GA-10
GA-10
NALM-6
NALM-6
TALL-1
TALL-1
JHOC-5
LOU-NH91
COLO-829
5637
NCI-N87
DU-4475
NCI-H1563
JL-1
T3M-10
SNU-449
SW 1353
C2BBe1
Panc 02.03
HDLM-2
SNU-1105
BT320
TE-14
BxPC-3
Panc 04.03
GAMG
KP-2
LC-1/sq-SF
ZR-75-30
KYSE-70
SW48
RL95-2
NCI-H2342
OVCAR-4
NCI-H2085
253J-BV
Pfeiffer
KASUMI-1
BT112
SK-MM-2
MEC-1
JURKAT
OCI-LY3
JM1
P12-ICHIKAWA
NCI-H2141
MOLT-13
P31-FUJ
IMR-32
KE-37
RPMI-8402
A673
BT164
MOLP-8
D-283MED
ST486
PEER
SUP-T11
Daudi
OCI-M1
SKM-1
NCI-H1341
MHH-CALL-4
GA-10
NALM-6
TALL-1
JHOC-5: 16.89 (log10 µM)
Synonyms: JHOC-5, JHOC5
LOU-NH91: 16.75 (log10 µM)
Synonyms: LOU-NH91, LOUNH91
COLO-829: 15.34 (log10 µM)
Synonyms: COLO-829, COLO 829, COLO_829, COLO829
5637: 15.00 (log10 µM)
Synonyms: 5637
NCI-N87: 14.71 (log10 µM)
Synonyms: NCI-N87, NCIN87
DU-4475: 14.16 (log10 µM)
Synonyms: DU-4475, DU4475, du4475
NCI-H1563: 12.05 (log10 µM)
Synonyms: NCI-H1563, NCIH1563
JL-1: 11.38 (log10 µM)
Synonyms: JL-1, JL1
T3M-10: 11.25 (log10 µM)
Synonyms: T3M-10, T3M10
SNU-449: 9.96 (log10 µM)
Synonyms: SNU-449, SNU449
SW 1353: 9.56 (log10 µM)
Synonyms: SW 1353, SW_1353, SW1353
C2BBe1: 8.84 (log10 µM)
Synonyms: C2BBe1, C2BBE1
Panc 02.03: 8.72 (log10 µM)
Synonyms: Panc 02.03, Panc_02.03, PANC-02-03, PANC0203
HDLM-2: 8.72 (log10 µM)
Synonyms: HDLM-2, HDLM2
SNU-1105: 7.80 (log10 µM)
Synonyms: SNU-1105, SNU1105
BT320: 7.80 (log10 µM)
Synonyms: BT320
TE-14: 7.79 (log10 µM)
Synonyms: TE-14, TE14
BxPC-3: 7.39 (log10 µM)
Synonyms: BxPC-3, BXPC3
Panc 04.03: 7.21 (log10 µM)
Synonyms: Panc 04.03, Panc_04.03, PANC-04-03, PANC0403
GAMG: 6.67 (log10 µM)
Synonyms: GAMG
KP-2: 6.60 (log10 µM)
Synonyms: KP-2, KP2
LC-1/sq-SF: 6.19 (log10 µM)
Synonyms: LC-1/sq-SF, LC1SQSF
ZR-75-30: 6.09 (log10 µM)
Synonyms: ZR-75-30, ZR7530, zr7530
KYSE-70: 6.00 (log10 µM)
Synonyms: KYSE-70, KYSE70
SW48: 6.00 (log10 µM)
Synonyms: SW48, SW 48
RL95-2: 5.74 (log10 µM)
Synonyms: RL95-2, RL952
NCI-H2342: 5.70 (log10 µM)
Synonyms: NCI-H2342, NCIH2342
OVCAR-4: 5.58 (log10 µM)
Synonyms: OVCAR-4, OVCAR4
NCI-H2085: 5.53 (log10 µM)
Synonyms: NCI-H2085, NCIH2085
253J-BV: 5.51 (log10 µM)
Synonyms: 253J-BV, 253JBV
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
Pfeiffer: 1.50 (log10 µM)
Synonyms: Pfeiffer, PFEIFFER
KASUMI-1: 1.49 (log10 µM)
Synonyms: KASUMI-1, Kasumi-1, KASUMI1
BT112: 1.48 (log10 µM)
Synonyms: BT112
SK-MM-2: 1.48 (log10 µM)
Synonyms: SK-MM-2, SKMM2
MEC-1: 1.47 (log10 µM)
Synonyms: MEC-1, MEC1
JURKAT: 1.47 (log10 µM)
Synonyms: JURKAT, Jurkat
OCI-LY3: 1.46 (log10 µM)
Synonyms: OCI-LY3, OCI-LY-3, OCILY3
JM1: 1.45 (log10 µM)
Synonyms: JM1
P12-ICHIKAWA: 1.45 (log10 µM)
Synonyms: P12-ICHIKAWA, P12ICHIKAWA
NCI-H2141: 1.44 (log10 µM)
Synonyms: NCI-H2141, NCIH2141
MOLT-13: 1.44 (log10 µM)
Synonyms: MOLT-13, MOLT13
P31-FUJ: 1.41 (log10 µM)
Synonyms: P31-FUJ, P31/FUJ, P31_FUJ, P31FUJ
IMR-32: 1.40 (log10 µM)
Synonyms: IMR-32, IMR32
KE-37: 1.39 (log10 µM)
Synonyms: KE-37, KE37
RPMI-8402: 1.36 (log10 µM)
Synonyms: RPMI-8402, RPMI8402
A673: 1.35 (log10 µM)
Synonyms: A673, A-673
BT164: 1.34 (log10 µM)
Synonyms: BT164
MOLP-8: 1.32 (log10 µM)
Synonyms: MOLP-8, MOLP8
D-283MED: 1.28 (log10 µM)
Synonyms: D-283MED, D283 Med, D283_Med, D283MED
ST486: 1.28 (log10 µM)
Synonyms: ST486
PEER: 1.28 (log10 µM)
Synonyms: PEER
SUP-T11: 1.21 (log10 µM)
Synonyms: SUP-T11, SUPT11
Daudi: 1.20 (log10 µM)
Synonyms: Daudi, DAUDI
OCI-M1: 1.19 (log10 µM)
Synonyms: OCI-M1, OCIM1
SKM-1: 1.19 (log10 µM)
Synonyms: SKM-1, SKM1
NCI-H1341: 1.17 (log10 µM)
Synonyms: NCI-H1341, NCIH1341
MHH-CALL-4: 1.14 (log10 µM)
Synonyms: MHH-CALL-4, MHHCALL4
GA-10: 1.13 (log10 µM)
Synonyms: GA-10, GA10
NALM-6: 1.12 (log10 µM)
Synonyms: NALM-6, NALM6
TALL-1: 1.10 (log10 µM)
Synonyms: TALL-1, TALL1
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
SKI-II: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
urinary_tract
urinary_tract
stomach
stomach
large_intestine
large_intestine
skin
skin
breast
breast
ovary
ovary
pancreas
pancreas
central_nervous_system
central_nervous_system
lung
lung
upper_aerodigestive_tract
upper_aerodigestive_tract
oesophagus
oesophagus
endometrium
endometrium
unknown
unknown
soft_tissue
soft_tissue
prostate
prostate
cervix
cervix
liver
liver
kidney
kidney
bone
bone
biliary_tract
biliary_tract
thyroid
thyroid
autonomic_ganglia
autonomic_ganglia
pleura
pleura
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
salivary_gland
salivary_gland
0.00
1.00
2.00
3.00
4.00
5.00
6.00
7.00
8.00
salivary_gland
salivary_gland
cervix
cervix
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
autonomic_ganglia
autonomic_ganglia
thyroid
thyroid
bone
bone
unknown
unknown
soft_tissue
soft_tissue
breast
breast
large_intestine
large_intestine
stomach
stomach
endometrium
endometrium
lung
lung
urinary_tract
urinary_tract
central_nervous_system
central_nervous_system
biliary_tract
biliary_tract
upper_aerodigestive_tract
upper_aerodigestive_tract
pancreas
pancreas
ovary
ovary
liver
liver
kidney
kidney
skin
skin
prostate
prostate
oesophagus
oesophagus
pleura
pleura
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to SKI-II
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
CARMIL2
CTRPv2
pan-cancer
AAC
0.19
4e-05
mRNA
MEX3C
CTRPv2
pan-cancer
AAC
0.16
4e-05
mRNA
TMEM256
CTRPv2
pan-cancer
AAC
-0.15
4e-05
mRNA
NUMA1
CTRPv2
pan-cancer
AAC
0.15
5e-05
mRNA
HNRNPA1
CTRPv2
pan-cancer
AAC
0.17
5e-05
mRNA
IKZF2
CTRPv2
pan-cancer
AAC
0.16
5e-05
mRNA
PIK3R3
CTRPv2
pan-cancer
AAC
0.16
5e-05
mRNA
PAXBP1
CTRPv2
pan-cancer
AAC
0.16
5e-05
mRNA
SSBP2
CTRPv2
pan-cancer
AAC
0.16
5e-05
mRNA
RNASEK
CTRPv2
pan-cancer
AAC
-0.15
5e-05
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